Many of us in the functional medicine space are thinking about Akkermansia: what exactly makes this gut bug a keystone strain for health and longevity? I am excited to tackle this with a founder of Pendulum Therapeutics, Colleen Cutcliffe, PhD, an excellent scientist and a leader in biotech. Her passion to help her daughter, and many others, overcome food sensitivities inspired Colleen to use biotech and research to develop products that have the efficacy of a drug, but the safety of a probiotic. We cover it all, and then some! Enjoy, and let me know what you think. ~DrKF

Health & Fitness

Dr. Elisa Song is one of those clinicians that I could just keep talking to! She's a respected colleague and pioneer in pediatric functional medicine with so many practical tips for navigating childhood illness and health. Need to get your kiddo/patient through a blood draw they don't want to do? Or get your picky eater to take their supplement? Dr. Song has the answers. I appreciate her candor as she talks about how and why her practice has evolved in certain areas (such as in the use of targeted probiotics and even "psychobiotics" for autism, ADHD, anxiety, OCD and more) and in spelling out which supplement brands and doses she uses and why. Dr. Song tackles the immense challenges impacting the health of our kids and teens head on with positivity and smart, doable strategies for lasting success. This is a fascinating and empowering discussion with many clinical pearls that I will be implementing both in practice and for my own daughter going forwards. I hope you enjoy it too! ~DrKF

  Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.
 
  Guest Information
  
	Dr. Elisa Song, MD
	Healthy Kids, Happy Kids: An Integrative Pediatrician’s Guide to Whole Child Resilience: https://www.healthykidshappykids.com/book/
	Healthy Kids, Happy Kids: https://healthykidshappykids.com/
	IG: @healthykids_happykids
	FB: https://www.facebook.com/DrElisaSongMD/
  

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  Show Notes
  
	A Potential Decline in Life Expectancy in the United States…https://tinyurl.com/3frr8z6d
	Lost microbes of COVID-19: Bifidobacterium… https://tinyurl.com/r348tm78
	Increasing Prevalence of Antinuclear Antibodies… https://tinyurl.com/7why9yrv
	Role of Bifidobacteria on Infant Health: https://tinyurl.com/4sk5u9ds
	Protective effect of Bifidobacterium infantis CGMCC313-2 on… https://tinyurl.com/2kn2vjnw
	Trends in Consumption of Ultraprocessed Foods Among US Youths… https://tinyurl.com/5fn5sce7
	Dietary patterns, brain morphology and cognitive performance in children…https://tinyurl.com/mp5ekp26
  

Smart, Actionable Strategies for Childhood Resilience, with Dr. Elisa Song

Even as we prioritize natural interventions in functional medicine, GLP-1 agonist drugs such as Wegovy and Ozempic offer sometimes life-changing support for those who have long struggled with resistant overweight/obesity and high blood sugar. However, there are side effects, including the risk of substantial muscle loss and sagging, aged skin ("Ozempic face" as it's indelicately known). It's a concern that hits home for me, considering the pivotal role we know that muscle plays in overall health and longevity.

In this New Frontiers podcast episode I welcome back Dr. Anurag Singh to unravel the complexities of these issues. We explore the interplay between metabolic health and muscle preservation, touching on everything from the mechanisms of GLP-1 agonists and their long-term effects on aging and sarcopenia, to the promising potential of dietary and lifestyle interventions to counteract negative effects. We consider the potential for one of my all-time fave postbiotic epinutrients - Urolithin A - to assist by supporting mitochondrial health and preserving/enhancing muscle quality. This timely conversation is one you won't want to miss. Tune in and please leave us a review wherever you listen to New Frontiers. – DrKF

Check out our show notes https://www.drkarafitzgerald.com/fxmed-podcast/

Guest information
Anurag Singh, MD, PhD
Chief Medical Officer at Timeline

Thank you to our sponsor

  Timeline
  Mitopure
  Research from Timeline
  care@timeline.com

Timeline Discount for New Frontiers Listeners

Timeline is offering DrKFs readers a 10% discount on Timeline products. Head over to Timeline and use the code KARA10 at checkout.

Show Notes

  Study: Once-Weekly Semaglutide in Adults with Overweight or Obesity https://tinyurl.com/y3c2ypkw

  Pre-clinical trial (Recruiting): Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55>= Years Old...https://tinyurl.com/bdzfccr8

  Study: Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults https://tinyurl.com/2p9pjpxc

  Study: Antidiabetic Effect of Urolithin A in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Glucose Intolerance https://tinyurl.com/2jkhmu9w

  Study: Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis https://tinyurl.com/mvrjxxsm

  Study: Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults A Randomized Clinical Trial https://tinyurl.com/fscfdd85

  Study: Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population https://tinyurl.com/e6npdvyp

  Preprint article: Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials https://tinyurl.com/2m2nzd56

Mitigating Muscle Loss from GLP-1 Agonists, with Dr. Anurag Singh

Dr. Sandison confesses that when she first heard Dr. Dale Bredesen talk about his work reversing cognitive decline and Alzheimer's disease she was skeptical. But when she started to apply the Bredesen principles in her clinical work and saw just how meaningful the improvements were to patients' symptoms and quality of life, as she puts it: "...how do I do anything else with my life, but basically tell as many people who will listen that this is possible?" She then went on to found the first two residential care facilities for individuals with cognitive decline that are based on the Bredesen approach. She's published research on her clinical outcomes and is continuing to gather more data for publication. The information and inspiration she shares are relevant to anyone dealing with cognitive decline, caring for someone with cognitive decline, or even those of us who want to preserve and optimize cognitive function as we move through life. I found her report that environmental toxins were one of the most common findings among her patient population illuminating. - DrKF 

Head to https://www.drkarafitzgerald.com/fxme... for the transcription and all the resources.

Guest information

  Dr. Heather Sandison, ND, Author Reversing Alzheimer’s
  https://www.drheathersandison.com/
  Email: drheathersandisonnd@gmail.com


Thank you to our Sponsors

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  Midroll
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Show Notes

  Reversing Alzheimer's by Dr. Heather Sandison :https://tinyurl.com/3hcywxxv
  Dr. Dale Bredesen: https://www.apollohealthco.com/dr-bre...
  Montreal Cognitive Assessment (MoCa): https://mocacognition.com/
  Marama Residential Care Facility: https://www.maramaexperience.com/ 
  Study: Observed Improvement in Cognition During a Personalized Lifestyle Intervention in People with Cognitive Decline: https://www.ncbi.nlm.nih.gov/pmc/arti...
  Study: Precision Medicine Approach to Alzheimer’s Disease: Successful Pilot Project: https://www.ncbi.nlm.nih.gov/pmc/arti...


DrKF Resources

  Podcast: Addressing Root Causes of Neurodegenerative Diseases with Dr. Dale Bredesen: https://tinyurl.com/3f2jchcm
  DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://www.drkarafitzgerald.com/our-...
  Younger You Group Program: https://www.drkarafitzgerald.com/youn...

Tackling Alzheimer's Disease Head On - the Inspiring Work of Dr. Heather Sandison

Get ready for a deep dive into the world of cellular senescence and its implications for aging. Dr. Greg Kelly joins me on New Frontiers to explain the science behind targeting this Hallmark of Aging and share natural compounds and activities that target cellular senescence. I am particularly excited for you to hear his thoughts around dosing and cyclical timing of exposure to senolytic compounds, such as fisetin, luteolin, quercetin, and piperlongumine, and why that may make the difference between having the effect you want... or not. Don't miss his advice on smart exercise tweaks for aging and the caution that overdoing it with exercise in our later years is much more harmful than it was in our twenties. Lots to unpack here. Enjoy! - DrKF
 


Head over to https://www.drkarafitzgerald.com/fxmed-podcast/ for all the full transcription and all relevant links and resources.

Guest information

  Dr. Greg Kelly is Senior Director of Product Development at Neurohacker Collective, naturopathic physician (N.D.), and author of the book Shape Shift.
  Email: greg@neurohacker.com
  Facebook: https://www.facebook.com/neurohackercollective
  Instagram: https://www.instagram.com/neurohacker/
  LinkedIn: https://www.linkedin.com/in/gregory-kelly-98b96b138/


Qualia Discount for New Frontiers Listeners
If you’re in your late 20’s or older, adding Qualia Senolytic to your diet can play a CRUCIAL role in combating negative aging symptoms. Go to https://tinyurl.com/3zpsaw3s for up to 50% off Qualia Senolytic and as a listener of New Frontiers podcast use code KARA at checkout for an extra 15% off your first purchase.

Show Notes

  Dr. Gregory Kelly: https://neurohacker.com/people/greg-kelly
  Neurohacker Collective: https://tinyurl.com/3zpsaw3s
  Shape Shift: https://tinyurl.com/3zpsaw3s
  Alternative Medicine Review: https://tinyurl.com/56ad9av9

  OMEMI Trial - https://pubmed.ncbi.nlm.nih.gov/33191772/
  REDUCE-IT Study - https://clinicaltrials.gov/study/NCT01492361
  ASCEND Study - https://ascend.medsci.ox.ac.uk
  VITAL Study - https://www.vitalstudy.org/
  Longitudinal Study - Multi-omics Biological Age Estimation and Its Correlation with Wellness and Disease Phenotypes - https://tinyurl.com/2p85yx5f



DrKF Resources
Patient consults with DrKF physicians including Younger You Concierge: https://www.drkarafitzgerald.com/our-clinic/our-services/
Bio Age Lab Test: https://youngeryouprogram.com/bio-age-lab-test/
Bio Age Self Assessment Quiz: https://youngeryouprogram.com/basa/
Younger You Group Program: https://www.drkarafitzgerald.com/younger-you-intensive-virtual-group/
Younger You book: https://youngeryouprogram.com/book/

Targeting Senescent Cells? Dose and Timing Matters - with Dr. Greg Kelly

I'm excited to welcome Dr. Barry Sears, the renowned creator of the Zone Diet and a pillar in our field. Dr. Sears has not only authored bestsellers but has also made incredibly important contributions to clinical practice which we still rely on today: He is, for instance, the scientist who put the use of the AA:EPA ratio on the map. Dr. Sears provides elegant and accessible explanations of the unassailable importance of diet in addressing inflammation, metabolic health, chronic disease, and longevity, and the role that fatty acids play in that milieu. And while he and I might not agree that polyphenols need to be absorbed intact for benefit - there's plenty of evidence that their postbiotic products are very important players, especially in their interactions with the epigenome - his concerns about the chemical structure of highly concentrated fish oil supplements (with the potential for isomerization, as he argues) has opened my eyes and is important, without doubt. I think the jury is still out as to whether there is a negative influence of isomerization in highly concentrated EPA and DHA, but it's worthy of further investigation and (importantly) is another factor in the argument for a whole-food approach. - DrKF


Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.

Guest information

  Dr. Barry Sears, President, Inflammation Research Foundation and CEO of Zone Labs.Inc.
  Email: bsears@drsears.com
  Website: http://www.drsears.com/
  Zone Living Website: http://www.zoneliving.com/
  Inflammation Research Foundation: http://www.inflammationresearchfoundation.org/


Thank you to our Sponsors

  Diamond
  Rupa Health - https://tinyurl.com/yc26f6sj
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  OneSkin - https://tinyurl.com/ycxvz5we
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  Midroll
  Practice Better - Start your free trial and save 20% for 4 months on any paid plan with code KF20 - https://sites.practicebetter.io/new-frontiers-in-functional-medicine


Show Notes

  Dietary Control of Inflammation and Resolution - https://tinyurl.com/vadkjzf7
  The STRENGTH trial - https://tinyurl.com/282cz27m
  OMEMI Trial - https://pubmed.ncbi.nlm.nih.gov/33191772/
  REDUCE-IT Study - https://clinicaltrials.gov/study/NCT01492361
  ASCEND Study - https://ascend.medsci.ox.ac.uk
  VITAL Study - https://www.vitalstudy.org/
  Longitudinal Study - Multi-omics Biological Age Estimation and Its Correlation with Wellness and Disease Phenotypes - https://tinyurl.com/2p85yx5f


Sponsored | Latest Evidence and Clinical Applications of Akkermansia with Dr. Colleen Cutcliffe

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