May 29, 2025

Sucralose Might Be the Reason You Can’t Lose Weight - AI Podcast

7 minutes

Story at-a-glance

A recent study shows that sucralose activates brain regions tied to hunger and food motivation, leaving your body in a state of confusion that increases cravings instead of curbing them
Sucralose alters connections between the hypothalamus and anterior cingulate cortex — brain regions that weigh risks and rewards — leading to stronger urges to eat, especially in women and those with obesity
Unlike sucrose, sucralose failed to increase insulin and GLP-1 — hormones that signal fullness — resulting in a body that thinks it’s eaten but gets no confirmation from key metabolic pathways
Just 10 weeks of sucralose use was enough to trigger gut dysbiosis in healthy adults, with a measurable impact on insulin sensitivity and a rise in inflammation linked to liver and colon issues
Mice fed sucralose at levels considered “safe” were less able to fight infection and cancer due to impaired T cell activation — effects that reversed only after sucralose was removed from their diet

...more

By Dr. Mercola

4.6

14671,467 ratings

May 29, 2025

7 minutes

Story at-a-glance

A recent study shows that sucralose activates brain regions tied to hunger and food motivation, leaving your body in a state of confusion that increases cravings instead of curbing them
Sucralose alters connections between the hypothalamus and anterior cingulate cortex — brain regions that weigh risks and rewards — leading to stronger urges to eat, especially in women and those with obesity
Unlike sucrose, sucralose failed to increase insulin and GLP-1 — hormones that signal fullness — resulting in a body that thinks it’s eaten but gets no confirmation from key metabolic pathways
Just 10 weeks of sucralose use was enough to trigger gut dysbiosis in healthy adults, with a measurable impact on insulin sensitivity and a rise in inflammation linked to liver and colon issues
Mice fed sucralose at levels considered “safe” were less able to fight infection and cancer due to impaired T cell activation — effects that reversed only after sucralose was removed from their diet

...more