Methylation imbalance and the causative factors leading to methylation imbalance, like the MTHFR gene mutation, show themselves in four distinct personality types. These methylation personality types, methylation archetypes, or MTHFR personalities are called The Achiever, The Athlete, The Activist, and The Artist.

The Activist and The Artist are very closely linked. Neither are terribly ambitious or driven, except in the thing that matters to them, whether it's their art, their job (which might not be art or activism), or the cause that matters to them. Both tend to have fewer allergic-type reactions but are more likely to have food sensitivities or chemical sensitivities. Things like wheat sensitivity, soy sensitivity, rashes with the wrong laundry detergent, or headaches after smelling perfume. Both of these personalities thrive on leftovers and fermented foods, even though leftovers and fermented foods are high in histamine.These two personality types also tend to react predictably to supplements, nutrients, and even pharmaceutical drugs. Anything that boosts serotonin, so SSRI medications, St. John's Wort, and melatonin aren't great for these groups. Likewise, the major methyl donors like SAMe, TMG, and DMG are typically not well tolerated by the artist and the activist.

Conversely, these groups usually do very well with good sources of folate, like L-5MTHF, food-sourced folate, or folinic acid. Like all people with methylation imbalance, folic acid should not be taken because it can make methylation imbalances worse. Also, the benzodiazepine class of pharmaceuticals is usually well tolerated (although your doctor knows the best choice of pharmaceuticals for you, and your doctor's information is always more informed and correct for you than ours.)

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