The Dr. Gabrielle Lyon Show

The receptor that switches off your appetite on a GLP-1 drug is the same one wired into your reward circuitry, your hormones, and your blood vessels, which means when you turn down hunger, something else may be getting turned down too, and for most people taking these drugs, nobody ever checked.

In this solo episode, Dr. Gabrielle Lyon discusses:

• Why the same drug class can improve sexual function in men with obesity while potentially dampening it in lean or postmenopausal women — and why the deciding factor isn't the drug, it's the body
• How rapid weight loss raises SHBG, the protein that soaks up free testosterone, so a "normal" total testosterone result can hide a real deficit your bloodwork won't flag
• Why women make up 60–70% of GLP-1 prescriptions yet the entire evidence base for female sexual function is two case reports, with zero validated questionnaires in any pivotal trial
• The three-tier action plan for anyone on or about to start a GLP-1 — baseline your sexual function first, get free testosterone tested, and protect muscle with protein and resistance training

Whether you're on a GLP-1 drug or considering one, you'll walk away knowing exactly what to measure before you start and what to watch for after — so a change in your sexual health gets caught as the vital sign it is, instead of being quietly dismissed.

Thank you to our sponsors:

• Cozy Earth - Go to https://bit.ly/44qcXtu for up to 20% off!
• Lucy - Get 20% off your next order with code DRLYON at https://bit.ly/3QEpYMX or find yours in store at https://bit.ly/3SGAEv3 .
• Kettle & Fire - Head to https://bit.ly/4oJokGu and use code DRLYON for 25% off sitewide. That is K-E-T-T-L-E and Fire dot com slash DRLYON, code DRLYON for 25% off. Also available at select Sprouts, Whole Foods, and Kroger locations nationwide.

Explore More from Dr. Gabrielle Lyon

• Premium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.com
• Weekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/
• Apply to become a patient: Personalized care with Dr. Lyon’s clinical team https://drgabriellelyon.com/new-patient-inquiry/

Connect with Dr. Gabrielle Lyon:

• Instagram: https://www.instagram.com/drgabriellelyon/
• TikTok: https://www.tiktok.com/@drgabriellelyon
• X (Twitter): https://x.com/drgabriellelyon
• Facebook: https://www.facebook.com/doctorgabriellelyon

Chapters

00:00 - Introduction

01:30 - The 35-year-old patient case

04:00 - The question: harm or help?

05:00 - The case against: the 4.5x ED study

06:30 - FAERS database and 182 reports

08:00 - Reward circuits, blood flow, and SHBG

11:00 - Women are 70%, the data is two case reports

12:30 - The case for: detection bias explained

15:00 - Validated studies show testosterone rising

17:00 - GLP-1 vs testosterone therapy and fertility

19:00 - Same receptor, different body

22:00 - Cross-examination: holes in both sides

26:00 - Why the drugs may not all be the same

30:00 - Confidence levels: what Lyon actually believes

33:00 - Tier 1: baseline, hormones, protein, training

35:00 - Tier 2 and 3: dose, molecule switch, adjuncts

36:30 - Your sexuality is a vital sign

If you found this episode valuable, share it with someone who would benefit from it.

Disclaimers: This episode includes paid sponsorships.

The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

You might think more cardio is the key to aging well but Lisa Smith-Batchen, who has run 135 miles through Death Valley ten times, says it's strength that actually carries you through the decades.

In this episode, Dr. Gabrielle Lyon sits down with Lisa Smith-Batchen, one of the most decorated ultra-endurance athletes in American history and a 10-time Badwater 135 finisher, to discuss:

• Why being strong matters more than being fast and why "it's not the running that helps me run, it's being strong"
• The first movement everyone should train at any age: sit to stand, followed by squats, wall sits, lunges, and pushups
• Why cutting protein after 60 backfires, and why Lisa fuels on roughly 80% protein calories during races
• How to start lifting late, her 85-year-old client went from 5-pound weights to 230-pound farmer carries
• The fall that ended her father's life, and why "pick your feet up" became her mission for aging athletes

You'll walk away with a clear, muscle-first blueprint for staying strong, mobile, and independent for life — and the motivation to start today instead of waiting for another Monday.

Thank you to our sponsors:

• Cozy Earth - Go to https://bit.ly/44qcXtu for up to 20% off!
• Lucy - Get 20% off your next order with code DRLYON at https://bit.ly/3QEpYMX or find yours in store at https://bit.ly/3SGAEv3 .
• Kettle & Fire - Head to https://bit.ly/4oJokGu and use code DRLYON for 25% off sitewide. That is K-E-T-T-L-E and Fire dot com slash DRLYON, code DRLYON for 25% off. Also available at select Sprouts, Whole Foods, and Kroger locations nationwide.

Explore More from Dr. Gabrielle Lyon

• Premium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.com
• Weekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/
• Apply to become a patient: Personalized care with Dr. Lyon’s clinical team https://drgabriellelyon.com/new-patient-inquiry/

Find Lisa Smith-Batchen at:

• Website: https://dreamchaserevents.com/
• Instagram: https://www.instagram.com/coachlisasmithbatchen
• Facebook: https://www.facebook.com/lisa.smithbatchen

Connect with Dr. Gabrielle Lyon:

• Instagram: https://www.instagram.com/drgabriellelyon/
• TikTok: https://www.tiktok.com/@drgabriellelyon
• X (Twitter): https://x.com/drgabriellelyon
• Facebook: https://www.facebook.com/doctorgabriellelyon

Chapters

00:00 - Introduction

02:10 - From marathon to the Badwater 135

05:31 - The first race and learning the hard way

06:41 - Inside the pain cave

13:46 - Why she went back ten times

16:51 - Bonking, hydration, and what changed

21:12 - Finding your why

28:04 - Running for something greater

33:25 - Strong over fast: the real secret

35:59 - The lifting myths men and women believe

44:13 - Where a beginner should start

47:02 - Sit to stand: the non-negotiable move

48:56 - The habit that killed her father

51:11 - Why falls are so devastating

54:14 - The danger of low-protein advice for older adults

59:00 - Stop waiting for Monday

01:01:37 - Fueling: protein, sodium, and calories per hour

01:13:01 - Why a DNF isn't failure

01:18:13 - Unfinished business and the right choice

If you found this episode valuable, share it with someone who would benefit from it.

Disclaimers: This episode includes paid sponsorships.

The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

What does it actually mean to win at the highest level? In this powerful compilation, I’m with 2024 CrossFit Games champion James Sprague, 2023 CrossFit Games champion Laura Horvath, and legendary endurance coach Chris Hinshaw to unpack the mental game behind elite performance, the vulnerability that follows victory, and why champions are often more fragile in the moments just after they win. What does winning mean to you right now?

Connect with James Sprague

Website: https://games.crossfit.com/athlete/900251

YouTube: https://youtube.com/@spraguerrrr?si=zTrH9d5valcjlq-t

Instagram: https://www.instagram.com/spraguerrrr/

Facebook: https://www.facebook.com/spraguerrrr/

Connect with Laura Horvath

Website: https://games.crossfit.com/athlete/591912

YouTube: https://youtube.com/@kaduzs23?si=3j8mXAnf38H7uGvi

Instagram: https://www.instagram.com/laurahorvaht/?hl=en

Facebook: https://www.facebook.com/laurhorvath/

TikTok: https://www.tiktok.com/@laurahorvaht

X: https://x.com/laurahorvaht

Connect with Chris Hinshaw

Website: https://www.aerobiccapacity.com/

Instagram: https://www.instagram.com/hinshaw363/

Facebook: https://www.facebook.com/hinshaw363/

Thank you to our sponsors:

Bodyhealth - Use the code “LYON20” to get 20% off your first order! https://bit.ly/4r2ImeF

Our Place - Use code “DRLYON” for 10% of sitewide. https://bit.ly/4r77SiU

Manukora - save 31% plus $25 worth of free gifts. https://bit.ly/4sglER1

Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST:

YouTube: https://bit.ly/4boCFC3

Spotify: https://bit.ly/4cWTbLG

Connect with Dr. Gabrielle Lyon:

Instagram: https://www.instagram.com/drgabriellelyon/

TikTok: https://www.tiktok.com/@drgabriellelyon

X (Twitter): https://x.com/drgabriellelyon

Facebook: https://www.facebook.com/doctorgabriellelyon

Timestamps:

00:00 - Intro of Show

00:52 - The Rogue Invitational and qualifying

01:41 - Applying friction in elite training

02:27 - Why winners are vulnerable

02:47 - CrossFit and HYROX recovery demands

03:23 - Active versus passive rest

04:14 - Why records keep breaking

05:18 - Training by feel without wearables

06:16 - Mastering movement before intensity

07:21 - Reframing pain as growth

08:25 - How CrossFit events are structured

09:47 - Building structural integrity

10:38 - The three bases of the sport

11:34 - Getting comfortable being uncomfortable

‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

This episode includes paid sponsorships.

Most men think erectile dysfunction is a bedroom problem and low testosterone is just a fact of getting older. This roundtable makes the case that both are early warning lights for your heart, your metabolism, and your long-term health and that ignoring them can cost you a decade.

In this episode, Dr. Gabrielle Lyon sits down with urologists and men's health specialists Dr. Mohit Khera, Dr. Larry Lipshultz, and Dr. Tobias Köhler to discuss:

• Why a 35-year-old with ED carries a ~15% risk of heart attack or stroke within 7 years, ~3.5x the risk of depression, and ~30% odds of diabetes or prediabetes and why a prescription alone misses all of it
• Why "age-related" testosterone decline is largely a misnomer: a healthy man shouldn't drop significantly with age, so falling T usually signals something reversible underneath
• How testosterone became the single best blood marker of a man's overall health, and the case for annual screening that almost no man gets
• What the TRAVERSE trial changed when the FDA removed testosterone's cardiovascular warning in 2025, debunking the prostate-cancer and heart-attack fears
• The 2-minute monthly self-exam every man should do to catch testicular cancer early, when it's ~99% curable

If you've been told your symptoms are "just aging" or you love a man who refuses to see a doctor. This conversation shows you how to read the signals your body gives long before a crisis hits.

Thank you to our sponsors:

• Body Health - Use the code LYON20 to get 20% off your first order https://bit.ly/4efgBuM
• Timeline - Get 20% off your Mitopure order at https://bit.ly/49LSbYz
• Branch Basics - Save 15% at https://bit.ly/4uuw4x3 with code DRLYON

Explore More from Dr. Gabrielle Lyon

• Premium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.com
• Weekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/
• Apply to become a patient: Personalized care with Dr. Lyon’s clinical team https://drgabriellelyon.com/new-patient-inquiry/

Find Dr. Larry Lipshultz at:

• Instagram: https://www.instagram.com/lipshultzmd?igsh=NTc4MTIwNjQ2YQ==
• Website: https://www.larrylipshultz.com/
• YouTube: https://www.youtube.com/@DrsAmyandLarry

Find Dr. Tobias Kohler

• Instagram: https://www.instagram.com/tobiaskohlermd?igsh=NTc4MTIwNjQ2YQ==
• X: https://x.com/sexhealthmd?s=11

Find Dr. Mohit Khera

• Instagram: https://www.instagram.com/drmohitkhera?igsh=NTc4MTIwNjQ2YQ%3D%3D
• X: https://x.com/DrMohitKhera
• Website: https://drmohitkhera.com/

Connect with Dr. Gabrielle Lyon:

• Instagram: https://www.instagram.com/drgabriellelyon/
• TikTok: @drgabriellelyon
• X (Twitter): https://x.com/drgabriellelyon
• Facebook: https://www.facebook.com/doctorgabriellelyon

Chapters

00:00 - Introduction

01:30 - What doctors got wrong about testosterone

05:05 - The prostate cancer myth, debunked

07:12 - The best marker of a man's health

11:51 - Is age-related decline actually real?

14:15 - How obesity crushes testosterone

18:11 - Testosterone and reversing diabetes

20:06 - GLP-1 versus testosterone

25:20 - What "low testosterone" really means

29:05 - Dosing, CAG repeats, and microdosing

42:34 - The TRAVERSE trial and FDA reversal

47:10 - The prostate saturation point

56:49 - Peptides, explained

01:03:00 - Why ED is a check engine light

01:08:26 - The desert of men's health care

01:11:06 - The case for annual screening

01:16:45 - Varicoceles and male fertility

01:20:03 - How to check for testicular cancer

01:26:44 - Final advice for men

If you found this episode valuable, share it with someone who would benefit from it.

Disclaimers: This episode includes paid sponsorships.

The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

Your ego isn’t the enemy, but if you’re not actively controlling it, it is running your team, your home, and your most important relationships. Jamie Cochran, COO of Echelon Front, has spent 13 years helping leaders fix the root cause most of them never look for.

The Women’s Leadership Assembly live event runs January 5–7, 2027 in Palm Springs. A free monthly webinar series runs year-round. More details here: https://events.echelonfront.com/product/assembly-004/?utm_source=google&utm_medium=cpc&utm_campaign=22652941380&utm_content=&utm_term=&utm_source=google&utm_medium=paid&utm_campaign=22652941380&utm_content=&utm_term=&gadid=&gad_source=1&gad_campaignid=22662710098&gclid=CjwKCAjwxITRBhBYEiwA6mZm7VZs1jY-jUq1ugoigo8XEDkYsRsSEpOs2eblax5TQOW-9LT_K-hVhBoC1RkQAvD_BwE

Thank you to our sponsors:

• Timeline - Get 20% off your Mitopure order at https://bit.ly/4dW6BGN
• BodyHealth - Use the code LYON20 to get 20% off your first order https://bit.ly/4uR4NWB
• Upgrade your kitchen with Our Place today. Visit https://bit.ly/4dSD4Pz and use code DRLYON for 10% off sitewide.

Explore More from Dr. Gabrielle Lyon

• Premium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.com
• Weekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/
• Apply to become a patient: Personalized care with Dr. Lyon’s clinical team https://drgabriellelyon.com/new-patient-inquiry/

Find Jamie Cochran at:

Website: https://echelonfront.com/

YouTube: https://youtube.com/@echelonfront?si=2x5aCudkXTvicfJO

Instagram: https://www.instagram.com/jamielynncochran/

Facebook: https://www.facebook.com/jamie.cochran.7/

LinkedIn: https://www.linkedin.com/in/jamie-lynn-cochran-5ab79013

Connect with Dr. Gabrielle Lyon:

• Instagram: https://www.instagram.com/drgabriellelyon/
• TikTok: https://www.tiktok.com/@drgabriellelyon
• X (Twitter): https://x.com/drgabriellelyon
• Facebook: https://www.facebook.com/doctorgabriellelyon

Chapters

00:00 ​Intro of Show

01:33 The Spartan Warrior Selection

02:25 Why Female Leadership Is Misunderstood

06:35 Are Leadership Tools Evolving or Constant?

07:12 What Is Extreme Ownership?

11:44 Owning It All vs. Doing It All

12:34 Female Leadership: Strength vs. Confidence vs. Aggression

17:57 Imposter Syndrome: Healthy or Dangerous?

23:37 Leadership Skills: Natural or Trainable?

31:00 Detachment from Emotion: On Making Better Decisions

32:32 Healthy Competition Against Women

36:20 Jamie’s Thyroid Cancer Diagnosis and Practicing Detachment

48:12 Avoidant Leaders and Default Aggressive Bias for Action

51:96 Top 3 Mistakes Leaders Make

52:43 The Leadership Capital Framework

57:54 The PIOS Framework: Problem, Impact, Ownership, Solution

1:00:10 When to End a Professional Relationship

1:04:29 The Women’s Leadership Assembly: Origin Story

1:07:05 Impact of Social Media on the Confidence of Young Girls

1:13:35 Compounding Habits that Improve Leadership over Time

1:14:55 Discipline as a Parenting Tool

1:22:07 Recognising when your Leadership Capacity is Failing

1:24:51 Women’s Assembly in January 2027: Palm Springs

If you found this episode valuable, share it with someone who would benefit from it.

Disclaimers: This episode includes paid sponsorships.

The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

Most men think erectile dysfunction is a bedroom problem. It's actually one of the earliest warning signs of cardiovascular disease, capable of showing up three to five years before a heart attack.

In this episode, Dr. Gabrielle Lyon sits down with Dr. Amy Pearlman, a urologist trained in men's sexual health, to discuss:

• Why ED is a symptom of vascular health, not a standalone disease and how the artery feeding the heart is roughly double the size of the one feeding the penis, so problems show up "down there" first
• Why "normal" testosterone can be meaningless, and the questions to ask before accepting a lab result that didn't flag
• How daily erections preserve penile tissue the way water keeps a sponge supple and why disuse can cost noticeable size over just a few months
• That cardiovascular exercise can rival ED medication for improving erectile function, making your heart health the real fix
• How to track erectile fitness before there's a problem, instead of waiting until something breaks

By the end, you'll understand the single signal your body uses to flag heart and metabolic risk early and the simple, mostly drug-free steps that protect both your cardiovascular health and your sexual function for life.

Thank you to our sponsors:

• Manukora - Go to https://bit.ly/3RCMrKx to save 31% plus $25 worth of free gifts.
• Timeline - Get 20% off your Mitopure order at https://bit.ly/4dW6BGN
• Bon Charge - Save 15% at https://bit.ly/433Xi2B with code DRLYON

Explore More from Dr. Gabrielle Lyon

• Premium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.com
• Weekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/
• Apply to become a patient: Personalized care with Dr. Lyon’s clinical team https://drgabriellelyon.com/new-patient-inquiry/

Listen to "Pearls of Wisdom" on all your favorite platforms!

Spotify: https://open.spotify.com/show/4uOhWn5DeVXO7D2ppa0RoV

Apple Podcasts: https://podcasts.apple.com/us/podcast/pearls-of-wisdom/id1617916659

Find Dr. Amy Pearlman at:

Website: https://www.primeinstitute.us/

YouTube: https://youtube.com/@docamyurology?si=oJ2LZ_sxMPYTaK41

Instagram: https://www.instagram.com/amypearlmanmd/

X: https://x.com/AmyPearlman1

LinkedIn: https://www.linkedin.com/in/amy-pearlman-54a2b0208

Connect with Dr. Gabrielle Lyon:

• Instagram: https://www.instagram.com/drgabriellelyon/
• TikTok: @drgabriellelyon
• X (Twitter): https://x.com/drgabriellelyon
• Facebook: https://www.facebook.com/doctorgabriellelyon

Timestamps

00:00 - Introduction

01:25 - Erections predict cardiac events

01:41 - The pen and artery analogy

03:40 - No health milestones for men

07:52 - Normal structure and function

11:45 - The five S's of men's health

21:24 - Why "normal" testosterone misleads

25:00 - Testosterone and fertility risk

31:05 - Steroids versus FDA-approved agents

41:13 - The untreated 25-year-old

43:56 - Sperm health and home testing

52:02 - Peyronie's disease and injury

1:01:34 - Protein, nutrition, supplements

1:05:09 - Daily Cialis as a pre-workout

1:13:32 - The sponge analogy

1:15:31 - Erectile fitness tracking

1:23:05 - The penis pump, used right

1:27:24 - Restoring lost size

1:35:00 - Traction and girth enhancement

1:46:00 - Women's anatomy and pleasure

If you found this episode valuable, share it with someone who would benefit from it.

Disclaimers: This episode includes paid sponsorships.

The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

Most people think the cholesterol number on their lab report tells them whether their heart is at risk. But former National Lipid Association President Dr. Kevin Maki explains that LDL is just one piece of a much bigger picture and focusing on it alone can mean missing the markers that matter most.

In this episode, Dr. Gabrielle Lyon sits down with Dr. Kevin Maki, former President of the National Lipid Association and co-editor-in-chief of the Journal of Clinical Lipidology, to discuss:

• Why ApoB and Lp(a) are better predictors of heart risk than LDL and why only about 2% of people ever get Lp(a) tested
• What a beef-vs-chicken feeding study revealed about red meat and cholesterol (the LDL results came back identical at 112 mg/dL)
• The evidence behind the seed oil debate, including why higher linoleic acid levels tracked with lower inflammation markers across a 2,000-person dataset
• Why the balance of cholesterol-raising and cholesterol-lowering foods matters more than saturated fat alone
• The simple "ABCs" framework: A1c, blood pressure, cholesterol - for actually lowering long-term cardiovascular risk

By the end, you'll know which numbers actually predict heart risk, which tests to ask your doctor for, and how to cut through the conflicting noise around fat so you can make evidence-based decisions for the long haul.

Thank you to our sponsors:

• OneSkin - Get 15% off at https://bit.ly/4tZnOpk with code DRLYON
• BodyHealth - Use the code LYON20 to get 20% off your first order https://bit.ly/48SJ7AC
• Amp - Visit https://bit.ly/3RcmqBz to get your AI-powered at-home gym for smarter, personalized training.

Explore More from Dr. Gabrielle Lyon

• Premium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.com
• Weekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/
• Apply to become a patient: Personalized care with Dr. Lyon’s clinical team https://drgabriellelyon.com/new-patient-inquiry/

Find Dr. Kevin Maki at:

• Midwest Biomedical Research: https://www.mbclinicalresearch.com/
• LinkedIn: / kevin-c-maki-phd-497ba34

Connect with Dr. Gabrielle Lyon:

• Instagram: https://www.instagram.com/drgabriellelyon/
• TikTok: @drgabriellelyon
• X (Twitter): https://x.com/drgabriellelyon
• Facebook: https://www.facebook.com/doctorgabriellelyon

Chapters

00:00 - Introduction

00:31 - Dr. Kevin Maki and the National Lipid Association

01:04 - New dietary guidelines and the LDL confusion

02:04 - What raises and lowers LDL cholesterol

03:51 - Cholesterol levels from birth through puberty

05:11 - The lipid panel kids should get before age 11

06:42 - Lp(a): the test only 2% of people get

08:18 - ApoB and the three risky particle types

11:35 - Do we have evidence for "lower is better"?

14:09 - The FLASH-GLICK risk factor framework

17:10 - The 10% saturated fat guideline explained

19:36 - Many dietary patterns can be healthy

24:50 - Beef vs. chicken: identical LDL results

27:10 - The balance of fatty acids that matters

29:24 - Olive oil vs. corn oil feeding study

31:00 - Lower for longer: 40-year risk reduction

34:15 - Genetic cholesterol disorders and risk

40:33 - The omega-3 index and why it matters

49:10 - Are seed oils really driving inflammation?

53:11 - How seed oils are processed and refined

1:07:48 - Inherited beliefs and outdated nutrition science

1:08:54 - Butter vs. cheese and high-fat dairy surprises

1:14:48 - Exercise effects on HDL and triglycerides

1:21:20 - The ABCs of reducing cardiovascular risk

If you found this episode valuable, share it with someone who would benefit from it.

Disclaimers: This episode includes paid sponsorships.

The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

Colorectal cancer is now the leading cancer killer in adults under 50, and patients in their 20s are presenting with metastatic disease that has nothing to do with family history. Most physicians are still telling young patients with rectal bleeding that it's probably just hemorrhoids and that's costing lives.

In this episode, Dr. Gabrielle Lyon sits down with Dr. Michelle Pearlman, a board-certified gastroenterologist and founder of a Miami-based gastro-metabolic clinic, to discuss:

• The specific warning signs every adult under 50 should never ignore, regardless of age including rectal bleeding, unintentional weight loss, and persistent abdominal pain
• Why GLP-1 medications like Ozempic and Zepbound are being miscategorized as weight loss drugs when they're actually metabolic reprogrammers with applications in fatty liver, sleep apnea, and inflammation
• The protein, fiber, and resistance training protocol Dr. Pearlman uses to protect muscle mass in patients on GLP-1 therapy
• How hormone replacement therapy combined with GLP-1s is changing body composition outcomes for perimenopausal women and why current guidelines are still 20 years behind the data
• Dr. Pearlman's personal osteoporosis diagnosis at 39, despite being a lifelong bodybuilder, and what it revealed about the diagnostic gaps in standard medicine

This conversation gives you the framework to recognize the warning signs most physicians are still missing, and the foundational habits; nutrition, resistance training, and hormone optimization that protect your gut, bones, and muscle through midlife and beyond.

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00:00 - Introduction: Colorectal cancer under 50

01:15 - The gastro-metabolic approach explained

03:30 - Why nutrition isn't taught in GI fellowship

05:45 - When the colonoscopy is normal but patients suffer

07:00 - Weight, reflux, and visceral fat

09:15 - PPIs, bone density, and long-term risk

11:30 - Three things to never do for gut health

14:00 - Ultra-processed food and early-onset cancer

16:45 - Rectal bleeding, warning signs, and age

19:00 - Screening guidelines and the obesity gap

22:30 - GLP-1 medications: history and mechanism

27:15 - Hunger, cravings, and food noise

30:00 - The stigma around metabolic medications

33:45 - Side effects: nausea, reflux, constipation

38:30 - Compounded formulations and pharmacy safety

42:00 - Hair loss, protein, and supplementation

45:15 - Pill versus injection delivery systems

49:30 - Fiber, the microbiome, and short-chain fatty acids

54:00 - GLP-1s plus hormone replacement therapy

58:45 - Testosterone, Kyzatrex, and women's bone health

1:03:00 - Pearlman's osteoporosis diagnosis at 39

1:09:30 - The diagnostic gap in standard medicine

1:14:00 - Building Bite MD and the future of nutrition tech

Disclaimers: This episode includes paid sponsorships.

The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

Most parents are quietly paving the road their kids were supposed to learn to walk on by themselves and Jocko Willink has spent 20 years watching what happens when that road is too smooth.

In this episode, Dr. Gabrielle Lyon sits down with Jocko Willink, retired Navy SEAL commander, founder of Echelon Front, and bestselling author of Extreme Ownership and Discipline Equals Freedom, to discuss:

• Why the "apex parent / apex kid" mindset is a quiet trap, and what to do instead of paving the road
• How nature vs nurture actually plays out and what you can and cannot shape in your child
• The one trait Jocko wants his kids to inherit (and why every virtue becomes a vice when pushed to the extreme)
• The lie that successful, high-functioning people tell themselves about wanting more
• The single most important trait of a great leader and the one habit Jocko says will make every other part of your life better starting tomorrow

You'll walk away with a clearer operating system for the kind of parent, leader, and person you actually want to be and the one habit Jocko swears is the highest-ROI move any human can make.

Thank you to our sponsors:

• BodyHealth - Use the code LYON20 to get 20% off your first order https://bit.ly/48SJ7AC
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• Branch Basics - Get 15% off the Premium Starter Kit at https://bit.ly/4eu4Mm8 with the code DRLYON.
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Watch on Spotify. If you’re subscribed to Spotify Premium, you don’t get any Spotify ads on my video.

• Premium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.com
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00:00 - Introduction: Leadership and parenting are the same skill

03:24 - Nature vs nurture and the kids who won't compete

06:56 - The guardrails of failure

07:48 - Dharma and the path kids are meant to walk

09:17 - The one trait Jocko wants his kids to inherit

11:33 - What daughters should learn about men from their fathers

13:32 - How men and women experience fear differently

14:24 - Rebuilding trust after good people do bad things

18:34 - Letting your daughter do cheerleading

21:22 - Hiring people by putting them in the real environment

24:22 - The lie successful people tell themselves

29:16 - Strategic thinking vs the donut decision

35:18 - What failure teaches that success cannot

38:25 - Why Jocko stopped being about himself

44:09 - Aging, losing movements, and rage against the dying of the light

46:49 - Why a leader has to be in physical shape

50:41 - The single most important trait of a leader

54:09 - The one habit that changes everything

If you found this episode valuable, share it with someone who would benefit from it.

Disclaimers: This episode includes paid sponsorships.

The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

Most men don't know they have a pelvic floor, and most doctors aren't trained to look for dysfunction in it. The result: testicles are being surgically removed for pain that's actually neuropathic, at double the rate of a far more effective nerve-sparing procedure.

In this episode, Dr. Gabrielle Lyon sits down with Dr. Susan Macdonald, a board-certified urologist, surgical program director at Penn State, and one of only ~30 U.S. specialists treating chronic pelvic pain in men, to discuss:

• Why "prostatitis" is often the wrong diagnosis, and how rounds of antibiotics mask the real problem
• The male pelvic floor anatomy almost no medical school teaches, and how to recognize dysfunction in yourself or a patient
• Off-label medications (Cymbalta, gabapentin, amitriptyline) that are quietly transforming chronic pelvic pain treatment
• Why erectile dysfunction is rising sharply in teenagers, and the role pornography plays in rewiring young brains
• Who actually qualifies for a penile implant, and what the surgery really involves

If you've been told your pain is "all in your head," or you're a clinician seeing patients fall through the cracks, this conversation gives you the framework, the language, and the next steps to find real answers.

Thank you to our sponsors:

• Manukora - Go to https://www.MANUKORA.com/DRLYON to save 31% plus $25 worth of free gifts.
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Explore More from Dr. Gabrielle Lyon

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Find Dr. Susan Macdonald at:

Instagram: https://www.instagram.com/drsusanmacdonald/

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LinkedIn: https://www.linkedin.com/in/susan-macdonald-506324191/

Connect with Dr. Gabrielle Lyon

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Chapters

00:00 - Introduction

01:42 - Meet Dr. Susan Macdonald

03:00 - The high-powered lawyer nobody could help

05:01 - Why testicle pain is 5% of urology visits

07:49 - Men have a pelvic floor (and what it does)

12:46 - How a man knows he has pelvic floor dysfunction

21:30 - Why these muscles are "too tight" in men

26:33 - Chronic pain rewires the brain

29:21 - Stress, trauma, and the mind-body connection

33:29 - Stretching, breathing, and self-treatment at home

36:21 - The medications that actually work (Cymbalta, gabapentin)

44:34 - Muscle relaxers, acupuncture, and the guidelines panel

55:09 - Sexual trauma and chronic pelvic pain

01:00:08 - The "pain plus" diagnostic framework

01:05:23 - The micro-surgical denervation surgery

01:08:36 - Erectile dysfunction in 17-year-olds

01:11:00 - How porn rewires young men's brains

01:18:27 - 40% of men by 40, 50% by 50

01:23:39 - Penile implants: who qualifies, how they work

01:28:10 - Stage 4 cancer at 42 and the pivot to teaching

01:34:17 - Living big with finite time

01:39:00 - Closing message to chronic pain patients

If you found this episode valuable, share it with someone who would benefit from it.

This episode includes paid sponsorships.

The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.