Want to think faster, remember more, and rewire your brain for high performance? This special archived episode breaks down the real nootropic stack, neuroplasticity tools, and brain optimization protocols Jim Kwik uses daily, plus the biohacking routines that rebuilt his cognition after traumatic brain injury. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with world-renowned brain coach Jim Kwik, bestselling author of Limitless and advisor to billionaires, athletes, and Hollywood performers. After being labeled “the boy with the broken brain” as a child, Jim transformed his life through functional medicine, nootropics, cold therapy, neurorehab, and smart supplementation. He’s now the go-to expert on learning how to learn, with cutting-edge insights on memory, speed reading, focus, and cognitive recovery. 

Together, they reveal the most effective supplements for brain optimization, how to stack smart drugs with sleep optimization, the surprising downside of alpha GPC, and why things like ketosis, mitochondrial support, and even Danger Coffee are essential for modern cognition. You’ll also hear why your brain speed depends on your metabolism, the forgotten science of post-traumatic growth, and how to combine breathing, fasting, and cold therapy for massive neuroplasticity gains. 

Jim also shares his Brain Animal system, a new way to personalize your learning, decision-making, and communication based on your unique cognitive style. From performance to parenting, he shows how your “brain type” influences every part of life and how to hack it for focus, clarity, and flow. 

This episode is packed with high-impact strategies for biohacking your brain, improving human performance, upgrading memory, and building real resilience using smarter not harder protocols. 

You’ll Learn: 

• What Jim Kwik takes daily for brain speed, cognition, and mental stamina 

• The exact nootropics Dave Asprey uses (and the ones he avoids) 

• How sleep apnea nearly destroyed Jim’s performance and how he hacked it 

• The connection between mitochondria, memory, and metabolism 

• Why brain inflammation blocks focus and cognitive clarity 

• When to use cold therapy, hyperbaric oxygen, and stem cells for brain repair 

• How to know if your brain needs more acetylcholine and what happens if you overdo it 

• The best biohacking tools for focus, speed reading, learning, and flow state 

• Why your brain animal determines how you learn, lead, and connect 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

Keyword Index: 

Acetylcholine supplements, Alpha GPC vs CDP choline, Post-traumatic growth brain, Stem cells for brain repair, Hyperbaric oxygen therapy for TBI, Brain inflammation supplements, Learning disabilities recovery, Best supplements for neurogenesis, Brain fog biohacks, Brainwave training programs, Smart drug protocols, Cognitive stack routines, Mitochondrial support for cognition, Electrolytes for brain performance, Danger Coffee brain benefits, ADHD nootropics protocol, Sleep apnea and cognition, High dopamine supplements, Brain types and learning styles, Upgrade Labs review 

 Thank you to our sponsors!  

• Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body’s really doing behind the surface. 
• GOT MOLD? | Go to http://gotmold.com/shop and use DAVE10 to save 10% and see what’s in your air. 
• BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 to save 20% off your first order of PerfectAmino. 

 Resources:  

• Jim's Website: https://www.jimkwik.com/ 

• Dave Asprey’s Website: https://daveasprey.com 

• Danger Coffee: https://dangercoffee.com/DAVE15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

• 0:00 — Introduction & Brain Health 

• 0:47 — Childhood Injury & Struggles 

• 2:53 — Adversity & Purpose 

• 6:31 — Nootropics & Optimization 

• 18:49 — Daily Biohacking Habits 

• 32:14 — Exercise & Brain Function 

• 34:21 — Learning & Cognition 

• 38:06 — Sleep & Resilience 

• 41:41 — Brain Types Explained 

• 52:16 — Parenting & Neuroplasticity 

• 57:19 — Limitless Update & Wrap-Up 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if the most powerful upgrades for brain energy, metabolism, and drive aren’t in mainstream medicine, but in rare peptides and misunderstood hormones? In this episode, you’ll discover the cutting-edge compounds, nootropics, and hormonal strategies that elite biohackers are using right now to optimize every part of their biology. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Jay Campbell and Hunter Williams, co-founders of BioLongevity Labs—a performance biotech company creating oral peptide-based products like BioMind and BioGutPro. Jay is a globally recognized expert in testosterone optimization, author of The TOT Bible, and a leading voice in hormone and peptide therapeutics. Hunter is a high-performance coach and podcast host focused on metabolism, mindset, and men’s health through functional medicine and advanced supplementation. 

In this high-energy, high-clarity conversation, the trio explore what’s working right now in advanced human performance, spanning hormone synergy, mitochondrial enhancement, libido compounds, nootropics, and muscle-preserving stacks. You’ll hear why Dave injects estradiol three times per week, how Jay and Hunter use oral bioregulators to improve gut-brain signaling, and what peptides are quietly reshaping the future of health. 

 You’ll Learn: 

• Who should use estradiol—and how it can protect brain performance in men 

• The real role of testosterone and estradiol synergy in male health and longevity 

• How BioLongevity Labs is innovating with oral peptide delivery for cognitive and gut health 

• Why peptides like BPC‑157, TB‑500, PT‑141, and SS‑31 are changing mitochondrial care 

• The truth about Melanotan‑1, SLU, AOD‑9604, GW‑501516, and BAM‑15 

• What makes BioMind and BioGutPro different from standard nootropic or probiotic stacks 

• Why libido and metabolic health are deeply connected 

• The dangers of unvetted peptide sources—and what to look for in quality and bioavailability 

This is essential listening for anyone serious about biohacking, hormone optimization, mitochondrial support, brain energy, nootropics, neuroplasticity, functional medicine, sleep optimization, metabolism, and smarter-not-harder living. 

Keyword Index: 

estradiol for men, Dave Asprey hormone therapy, Jay Campbell BioLongevity Labs, Hunter Williams performance coaching, BPC‑157 recovery peptide, TB‑500 tissue regeneration, PT‑141 libido peptide, SS‑31 mitochondria peptide, Melanotan‑1 for skin and mitochondria, SLU stack, AOD‑9604 fat loss peptide, GW‑501516 Cardarine, BAM‑15 mitochondrial uncoupler, oral peptide delivery, BioMind brain supplement, BioGutPro gut-brain axis, testosterone estradiol synergy, mitochondrial uncoupling, nootropic peptide stacks, performance biohacking supplements 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

 Thank you to our sponsors!  

• Puori | Head to http://puori.com/dave for 20% off, including subscriptions.  
• Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off.  
• ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. 

 Resources:  

• BioLongevity Labs Website: https://biolongevitylabs.com/?ref=DAVE# 

• Dave Asprey’s Website: https://daveasprey.com 

• Danger Coffee: https://dangercoffee.com/DAVE15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

00:00 – Trailer 

01:00 – Introduction & Early Days of Biohacking 

02:03 – Peptides 101: Foundations and Frameworks 

03:06 – Peptides for Healing, Cognition, and Longevity 

07:56 – Bioregulators and Russian Innovations 

11:07 – Side Effects and Safety of Peptides 

22:27 – Oral Peptides and Product Innovations 

27:41 – Body Composition, Hormones, and Fat Loss 

32:02 – Testosterone, Estrogen, and Male Health Protocols 

45:03 – Peptides for Performance, Fat Loss, and Longevity 

1:26:32 – Loose Skin, Surgery, and Body Transformation 

1:38:00 – Closing Thoughts & Product Recommendations 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Ready to learn about the secret compounds, molecules, nootropics, and stacks that Big Pharma doesn’t want you to know about? This episode is packed with the exact dopamine-boosting compounds, stacks, and biohacking protocols that top performers are using to supercharge human performance, brain optimization, and long-term resilience. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Lucas Aoun, Australia’s leading biohacker and founder of Ergogenic Health. Known for his fearless, data-driven experimentation, Lucas specializes in nootropics, dopamine modulation, mitochondria, and functional medicine. He’s spent over a decade testing underground compounds, natural molecules, and hormone-based strategies to achieve elite-level brain and body performance. 

Together, they explore Russian-developed enhancers like Bromantane and ITPP, and reveal how these rare compounds impact dopamine regulation, neuroplasticity, and mental drive. You’ll learn how to upregulate tyrosine hydroxylase (your brain’s dopamine switch), build targeted stacks for motivation and confidence, and avoid the common supplements that quietly kill your ambition. 

They also dive into the connection between dopamine and testosterone, explaining how to rewire hormonal feedback loops to reclaim masculinity, energy, and purpose. From libido hacks and prolactin suppression to stacking dopamine with GABA and acetylcholine, this episode gives you a complete system for motivation mastery. 

Other key topics include the dangers of chronic ashwagandha use, sleep optimization for dopamine recovery, the truth about adaptogens and cold therapy, ketosis, fasting, DHT science, ciproheptadine microdosing, and why mitochondrial support is essential for long-term performance and metabolism. 

You’ll Learn: 

• The #1 Russian compound for explosive dopamine and drive 

• Why most “calming” supplements destroy your ambition 

• How dopamine and DHT shape masculinity and performance 

• Advanced biohacks for sleep, motivation, libido, and mood 

• The truth about serotonin dominance and how to escape it 

• Which functional medicine tools enhance brain energy and metabolism 

• How to build your own dopamine protocol using proven nootropics 

• Why mitochondrial health is the hidden key to motivation and mood 

This is essential listening for anyone serious about biohacking, brain optimization, hormone hacking, nootropics, functional medicine, emotional resilience, and building a state of unstoppable energy. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

 Thank you to our sponsors!  

• OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY.  
• Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.  
• LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/DAVE. 

 Resources:  

• Lucas’s Website: https://www.boostyourbiology.com/ 

• Lucas’s YouTube: https://www.youtube.com/c/boostyourbiology 

• Dave Asprey’s Website: https://daveasprey.com 

• Danger Coffee: https://dangercoffee.com/DAVE15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Tags:  

dopamine boosters, russian nootropics, bromantane benefits, biohacking dopamine, boost motivation naturally, dopamine stack, lucas aoun podcast, dave asprey dopamine, nootropics for energy, secret russian compounds, brain optimization, biohacking supplements, increase dopamine levels, functional medicine hacks, hormone optimization, dopamine and testosterone, neuroplasticity hacks, superhuman energy, underground nootropics, dopamine protocols 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Getting 50 grams of protein per meal may be the single most underrated biohacking protein strategy for muscle growth, metabolism, and longevity. In this episode, you’ll discover why animal protein vs vegan is not a fair match biologically, how hitting the leucine threshold activates mTOR for longevity, and why muscle is the most overlooked organ of aging. This is must-listen content for anyone optimizing human performance, hacking metabolism, or reversing muscle loss with food. 

Host Dave Asprey is joined by Dr. Gabrielle Lyon, a pioneer in Muscle-Centric Medicine®, functional medicine expert, and top authority on clinical nutrition for longevity. Trained by protein researcher Dr. Donald Layman, she brings decades of expertise on how to use high-protein diets, amino acid science, and functional medicine to radically improve healthspan and brain optimization. Dr. Lyon works with everyone from special operators to aging patients, making her one of the most trusted voices in anti-aging diet strategies. 

Watch this channel on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

You’ll learn: 

• Why 50g of protein per meal matters more than total daily intake 

• How mTOR and longevity are misunderstood in mainstream nutrition 

• Why protein vs plant protein debates ignore hard biological data 

• How leucine thresholds determine muscle activation 

• Why fasting and protein cycling beats low-protein veganism 

• How ketosis and protein intake impact metabolic health 

• Why many on a vegan diet experience sleep issues, hormone crashes, and reduced resilience 

• How functional medicine podcasts like this one reveal the truth about aging and muscle loss 

• What happens clinically when patients switch to a high-protein diet 

• How to use supplements, nootropics, and protein hacks to enhance neuroplasticity, mitochondrial energy, and total body performance 

If you’ve ever asked “what’s the best protein for muscle growth?” or “how does protein affect metabolism in aging?”, this episode gives you evidence-based answers from the front lines of clinical nutrition. 

This channel is a must-listen for anyone serious about hacking their biology, upgrading cognitive performance, and using unconventional tools to create lasting transformation. Whether you’re tracking HRV, optimizing for deep sleep, or working toward metabolic resilience, these conversations deliver insights you won’t hear anywhere else. 

 Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

 Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

 Thank you to our sponsors!  

• 40 Years of Zen | Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com 
• fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.  
• Lumiram | Go to http://healthlighting.com/dave to save 10% on your order. 

 Resources:   

• Gabrielle’s Website: https://drgabriellelyon.com/ 

• Gabrielle’s IG: https://www.instagram.com/drgabriellelyon/ 

• Dave Asprey’s Website: https://daveasprey.com 

• Danger Coffee: https://dangercoffee.com/DAVE15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

• 0:00 Trailer 

• 0:51 Protein Controversy  

• 2:38 Leucine 

• 6:00 mTOR, Methionine, and Protein Synthesis 

• 9:00 Vegan vs. Carnivore 

• 16:00 Optimizing Protein Intake & Aging 

• 22:00 Carbohydrates, Hormones, and Female Health 

• 28:00 Environmental Impact & Food Sourcing 

• 34:00 Debunking Plant-Based Documentaries 

• 40:00 Key Takeaways & Closing 

Keywords: protein vs plant protein, 50 grams of protein, biohacking protein, mTOR and longevity, animal protein vs vegan, leucine threshold, Gabrielle Lyon, muscle-centric medicine, best protein for muscle growth, anti-aging diet, muscle as organ of longevity, fasting and protein, ketosis and protein, vegan diet risks, optimizing metabolism, high-protein diet, functional medicine podcast, Dave Asprey protein, aging and muscle loss, clinical nutrition for longevity 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This episode reveals how military-grade sound frequencies can rapidly shift your mental state, enhance neuroplasticity, and accelerate brain optimization. You’ll learn how to hack your nervous system using real-time biometric data, how frequency compositions are changing functional medicine, and why sound is emerging as one of the most powerful tools for human performance and longevity. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey is joined by Rev. Michael Beckwith, founder of the internationally renowned Agape International Spiritual Center and one of the most respected voices in spiritual transformation and human potential. With over four decades of teaching, Michael has impacted millions through his work in consciousness, meditation, and high-performance inner development. Joining him is Henry Penix, founder of SOAAK Technologies, a cutting-edge frequency healing platform trusted by clinicians, elite performers, and even the US Air Force. Together, they explore how sound can rewire brainwaves, reduce anxiety, support sleep optimization, and create measurable changes in metabolism, mood, and mindset. 

 You’ll learn: 

• How the Air Force is using frequency tech to support mental recovery and cognitive performance 

• What makes SOAAK’s custom sound compositions biologically effective 

• How sound impacts mitochondria, mood, and brainwave coherence 

• The link between sound healing, neuroplasticity, and high-performance states 

• Why hydration, supplements, and biohacking stacks boost sound-based protocols 

• The surprising connection between prayer, frequency, and emotional regulation 

• How to integrate sound biohacks with fasting, ketosis, sleep tools, and nootropics 

• Why this tech pairs with cold therapy, Danger Coffee, and smarter not harder principles 

This channel is a must-listen for anyone serious about hacking their biology, upgrading cognitive performance, and using unconventional tools to create lasting transformation. Whether you’re tracking HRV, optimizing for deep sleep, or working toward metabolic resilience, these conversations deliver insights you won’t hear anywhere else.  

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

 Thank you to our sponsors!  

• Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off.  
• Active Skin Repair | Visit http://activeskinrepair.com/ to learn more and use code DAVE to get 20% off your order.  
• ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order 

 Resources:  

• SOAAK Website: https://www.soaak.com/dave 

• Dave Asprey’s Website: https://daveasprey.com 

• Danger Coffee: https://dangercoffee.com/DAVE15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

• 0:00 — Trailer 

• 1:00 — Intro 

• 2:42 — Humor & Frequency 

• 5:20 — Soak App Origins 

• 8:15 — Biometrics & Sound Delivery 

• 10:40 — Inner Alignment & Brain Mapping 

• 13:46 — Beckwith’s Results 

• 19:44 — Sound & Biohacking 

• 23:32 — Mood & Sleep Shifts 

• 24:53 — Supplements & Water Synergy 

• 26:25 — Emotional Congruence 

• 29:49 — Frequency & Sexuality 

• 32:43 — Military & Medicine 

• 35:32 — Light, Sound & Quantum Effects 

• 40:34 — Analog vs. Digital Sound 

• 48:45 — Spiritual Experiences 

• 53:14 — Conclusion & CTA 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

You’ve been lied to about how long it takes to change a habit. This episode reveals a powerful, science-backed method to rewire your brain in just 63 seconds—without relying on willpower. You’ll discover how to use the 63-second window to interrupt destructive thought loops and how true habit change requires 63-day habit formation, not the popularized 21-day myth. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Dr. Caroline Leaf, a cognitive neuroscientist and best-selling author known for her groundbreaking work on the mind-brain connection. With over four decades of experience, Dr. Leaf has helped millions better understand the differences between the mind vs brain, how to harness intuition and neurobiology, and how to apply science-based tools for healing trauma with neuroscience. Her newest work, Help in a Hurry, builds on her bestselling book Cleaning Up Your Mental Mess, offering real-time tools to regain mental control during moments of emotional chaos. 

 You’ll learn: 

• Why the 21-day habit myth persists and what the neuroscience actually shows 

• How to use the 63-second window to stop toxic thoughts from wiring into your brain 

• What happens during the 63-day habit formation cycle and how to stay on track 

• The difference between the subconscious vs unconscious mind 

• How to rewire your brain for better emotional regulation and decision-making 

• The power of forgiveness and how it relates to quantum entanglement 

• Caroline Leaf’s mental mess strategies to overcome triggers in real time 

• Why the free will neuroscience debate matters for your mental sovereignty 

• How to interpret intuitive “blips” through a neuroscience lens 

• Tools for using neuroplasticity to heal trauma, manage emotions, and boost clarity 

This episode is a must-listen for anyone interested in brain optimization, biohacking, human performance, mental resilience, and smarter-not-harder strategies for personal growth. Whether you’re focused on fasting, cold therapy, nootropics, sleep optimization, or upgrading your mitochondria, these mental frameworks will amplify your results. 

 Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

 Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

Thank you to our sponsors!  

• Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order 
• IGNITON | Go to https://www.igniton.com/DAVE and use code DAVE to save 15%.

Resources:  

• Order Caroline’s New Book ‘Help in a Hurry’ - https://a.co/d/6O9RaJB 

• Caroline's Website: https://drleaf.com/ 

• Dave Asprey’s Website: https://daveasprey.com 

• Danger Coffee: https://dangercoffee.com/DAVE15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

 Timestamps: 

• 0:00 Trailer 

• 0:54 Intro 

• 1:12 63-Second Habit Rule 

• 5:14 21 vs 63 Days 

• 9:20 Habits vs Trauma 

• 14:19 Healing & Spiritual Insight 

• 17:43 Free Will & Mind-Brain Link 

• 19:11 Conscious vs Subconscious 

• 26:02 Intuition & Memory 

• 33:15 AI & Consciousness 

• 37:56 Death & Energy 

• 51:21 Forgiveness & Entanglement 

• 55:14 Self-Regulation Tools 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What is Herbal Ecstasy—and why does it matter? This might be one of the most insane episodes we’ve ever recorded, and we had to bring it back because the story is too wild, too relevant, and too packed with real lessons in biohacking, brain optimization, and supplement hacking to miss. 

Host Dave Asprey sits down with Shaahin Cheyene, the renegade teenage entrepreneur who built a billion-dollar supplement empire before he could legally drink. As the creator of Herbal Ecstasy, Shaahin hacked natural compounds into high-performance nootropics that boosted energy, neuroplasticity, and metabolism—long before biohacking was a movement. He faced seven federal investigations, never spent a day in jail, and went on to pioneer the vaporizer industry and dominate Amazon with advanced supplement marketing. 

 This episode explores how Shaahin reverse-engineered functional medicine principles, used ancient plant medicine to upgrade human performance, and scaled a controversial brand using raw hustle and hacking tactics. You’ll hear how Herbal Ecstasy worked, why it was banned, and what it teaches us about supplements, mitochondrial function, dopamine regulation, and the dark politics behind wellness innovation. 

 You’ll learn: 

• Why Herbal Ecstasy became a billion-dollar underground supplement 

• How Shaahin used nootropics and adaptogens to hack energy, focus, and neuroplasticity 

• What his clash with the FDA reveals about supplement regulation and functional medicine 

• How dopamine, mitochondria, and metabolism drive human performance 

• The difference between hacking systems vs conforming to broken ones 

• How storytelling, podcasting, and controversial supplements build legacy brands 

Whether you’re optimizing your sleep, hacking your brain, experimenting with ketosis or fasting, or upgrading your stack with supplements that actually work—this channel delivers strategies, cautionary tales, and insight you won’t find anywhere else. lt is essential listening for anyone serious about biohacking, brain optimization, supplements, mitochondria, metabolism, functional medicine, nootropics, longevity, dopamine, cold therapy, sleep optimization, emotional regulation, neuroplasticity, fasting, podcasting, RFK-era health freedom, ketosis, entrepreneurship, and building influence smarter not harder—with or without Danger Coffee. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

Thank you to our sponsors!  

Resources:  

• Shaahin’s Website: https://www.shaahincheyenne.com/ 

• Dave Asprey’s Website: https://daveasprey.com 

• Danger Coffee: https://dangercoffee.com/DAVE15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

• 0:00 — Trailer 

• 0:45 — Intro and guest setup 

• 4:39 — Escaping Iran and early hustle 

• 8:26 — Birth of Herbal Ecstasy 

• 14:21 — Explosive growth and legal heat 

• 25:06 — Lessons on money and business 

• 31:17 — Inventing the digital vaporizer 

• 40:03 — Hacking success on Amazon 

• 41:59 — Nootropics and the Limitless pill 

• 46:38 — Martial arts and mental resilience 

• 55:44 — Podcasting, media, and influence 

• 1:07:09 — Where to find Shaahin and closing thoughts 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

You’re leaving brainpower on the table, and this episode shows you how to reclaim it. Learn how to boost cognitive performance by 25% without relying on pills, stimulants, or gimmicks. Host Dave Asprey sits down with global finance expert and cross-cultural thinker Richard Conrad to explore how your cultural programming shapes your biology, metabolism, neuroplasticity, and even your ability to reach peak human performance. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Richard is the author of Culture Hacks and has spent over 30 years living and working across Japan, China, and the U.S. He’s a master of decoding hidden mental frameworks that influence perception, longevity, and decision-making. This is a must-listen if you care about brain optimization, functional medicine, and living smarter, not harder. 

Together, they break down why different cultures process truth, time, and identity so differently and how these filters influence your beliefs about supplements, fasting, cold therapy, sleep optimization, and more. You’ll also learn why Americans are biologically wired for linear logic, how agrarian versus warrior cultures shaped meditation and nervous system regulation, and how to train your mitochondria to perform like a samurai’s. 

You’ll Learn: 

• Why your culture shapes how your brain processes reality 

• How to shift from linear to systems thinking for better neuroplasticity 

• The connection between meditation styles, nervous system wiring, and mitochondria 

• How to apply ancient frameworks to modern biohacking and human performance 

• Why longevity without financial planning is a broken strategy 

• How to avoid cognitive bias by decoding relative versus absolute truth 

This channel is packed with biohacking wisdom, from nootropics and ketosis to Danger Coffee, financial resilience, and how your beliefs about aging could be accelerating it. Whether you’re focused on hacking your brain, upgrading your metabolism, or extending your longevity, this is one of the most unique mind-expanding channels around. It is essential listening for anyone passionate about biohacking longevity, functional aging, mitochondrial testing, and next-gen human optimization. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

Thank you to our sponsors!  

• Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.  
• OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY. 
• Generation Lab | Go to https://generationlab.com/, use code DAVE20 for $20 off, and see what your body’s really doing behind the surface. 

Resources:  

• Order Richard’s Book “Culture Hacks”: https://a.co/d/9122Q25 

• Dave Asprey’s Website: https://daveasprey.com 

• Danger Coffee: https://dangercoffee.com/DAVE15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

• 00:00 Trailer 

• 01:10 Intro 

• 03:15 Middle East Perception Gap 

• 06:53 China’s Strategy & Trade 

• 09:53 Japan vs China Mindsets 

• 14:28 Logic: East vs West 

• 18:23 Cultural Tools for Life 

• 24:23 Global Population Crash 

• 30:18 Shifting Economic Power 

• 55:33 Smart Finance Principles 

• 01:09:28 Real Estate & Policy 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This may be the most cutting-edge life extension technology you’ll hear about for decades. You’ll discover how mitochondrial transfusion, rejuvenation, and repair could reverse biological aging, supercharge your metabolism, and radically extend healthspan—all by upgrading the cellular energy systems that power every function in your body. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with inventor and tech entrepreneur Tom Benson, founder of Mitrix. After launching three successful Silicon Valley companies, Benson shifted focus to one of the most promising frontiers in science: mitochondrial bioreactors designed to regrow your own autologous mitochondria. This isn’t theory—it’s a near-future anti-aging technology poised to transform functional medicine, personalized medicine, and the global conversation around aging reversal. 

They explore how mitochondrial DNA mismatches affect aging, why mitochondria act like cellular AI cores, and how dysfunction in these ancient organelles contributes to neurodegenerative disease, metabolic decline, and cognitive disorders. You’ll learn how restoring mitochondria could enhance everything from stem cell therapy and nootropics to ketosis, fasting, cold therapy, and even sleep optimization. 

 You’ll Learn: 

• Why mitochondria may be the real control centers of human biology 

• How mitochondrial transfusion could revolutionize longevity and functional medicine 

• The connection between mitochondrial dysfunction and Parkinson’s, autism, and ALS 

• Why brain optimization and neuroplasticity depend on cellular energy 

• How stem cell-derived mitochondria compare to nootropics and NAD 

• What happens when mitochondrial DNA and nuclear DNA are mismatched 

• Why early aging might start with your egg cells’ mitochondrial computing 

• How mitochondrial health influences metabolism, ketosis, and fat storage 

• Why stress, toxins, and pharmaceuticals like statins wreck mitochondrial function 

• What it takes to scale mitochondrial bioreactors for widespread human use 

• How mitochondrial hacking could improve immune function, sleep, and resilience 

• Why the future of biohacking might begin with testing and upgrading your mitochondria 

This episode is essential listening for anyone passionate about biohacking longevity, functional aging, mitochondrial testing, and next-gen human optimization. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

Thank you to our sponsors!  

-ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order.  

-Active Skin Repair | Visit http://activeskinrepair.com/ to learn more and use code DAVE to get 20% off your order. 

Resources:  

• Mitrix Website: https://www.mitrix.bio/ 

• Dave Asprey’s Website: https://daveasprey.com 

• Danger Coffee: https://dangercoffee.com/DAVE15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

• 00:00 Trailer 

• 01:42 Intro 

• 04:33 Mitochondrial DNA & Performance 

• 08:49 Challenges in Mitochondrial Therapy 

• 13:31 Future Applications 

• 19:07 Mitochondria & Longevity 

• 20:19 Traditional Medicine 

• 28:50 Space Exploration 

• 29:35 Human Fragility 

• 30:19 Aging Revisited 

• 32:52 Experimental Research 

• 36:04 Ethics & Risks 

• 41:24 Mental Health Links 

• 46:28 Treatment Breakthroughs 

• 51:01 Personal Longevity Hacks 

• 54:30 Wrap-Up & Contact 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if one spray could upgrade your brain, protect your mitochondria, and outperform IV therapy and liposomal supplements? In this episode, you’ll discover the breakthrough science behind topical glutathione delivery that uses your skin’s water channels to raise intracellular glutathione levels in just 60 seconds. Learn how this powerful antioxidant works at the cellular level to reduce oxidative stress, support mitochondrial function, and drive real improvements in brain health, emotional resilience, and human performance. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Nayan Patel, a world-leading pharmacist and formulator who pioneered this next-gen delivery method. With over two decades of clinical work in functional medicine, Nayan has helped reshape how we think about glutathione benefits, systemic detox, and performance optimization. His research shows that topical delivery bypasses traditional fat-based absorption, achieving higher brain uptake and faster results than IVs or capsules. 

 You’ll learn: 

• Why glutathione for longevity is foundational to biohacking 

• How it protects against cellular inflammation and improves TBI recovery issues 

• Why pairing glutathione with NAD+, vitamin C, or pharmaceutical nicotine creates a powerful synergy 

• How it preserves NAD+, supports sirtuins, and enhances ATP production 

• When to use glutathione as an immune booster for resilience and recovery 

This conversation also reveals the truth behind liposomal supplements, how your age affects glutathione absorption, and why this molecule is critical for anyone using nootropics, in ketosis, or pushing metabolic limits. 

This episode is essential listening for anyone into biohacking, cold therapy, functional medicine, or RFK-style medical freedom. You’ll walk away with practical tools to boost nitric oxide naturally, prevent dysfunction, and optimize your biology whether you’re on a carnivore diet or just looking for an edge. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. 

Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. 

Resources:  

• Auro Wellness Website: Use code ‘dave10’ at checkout https://aurowellness.com/ 

• Dave Asprey’s Website: https://daveasprey.com 

• Danger Coffee: https://dangercoffee.com/DAVE15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

• 00:00 Trailer 

• 00:20 Intro 

• 01:12 Water Channel Delivery Explained 

• 02:25 What Makes Glutathione Special 

• 05:04 Why IVs and Liposomes Fail 

• 06:29 Measuring Glutathione in the Brain 

• 10:42 Key Benefits and Use Cases 

• 20:49 Emotional Resilience Effects 

• 23:54 Sensitivity and Response 

• 24:55 Best Timing for Use 

• 25:53 Workout Performance Boost 

• 26:47 Brain Health and TBI Support 

• 28:22 Best Stack Combinations 

• 29:32 Nicotine + Glutathione Synergy 

• 33:18 Longevity, Sirtuins, and Genes 

• 40:36 Glutathione as Immune Booster 

• 43:15 Peptides and Next-Gen Hacks 

• 45:29 Dosing Tips and Wrap-Up 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.