The Dr. Tyna Show

The Truth About the Middle Aged Middle | Solo Episode


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EP 163: In this special episode of The Dr. Tyna Show, I'm tackling the puzzling phenomenon of midlife weight gain—a challenge many of us women face. If you’ve noticed your midsection thickening and overall body changes as you hit middle age, you’re definitely not alone. I’ll break down a recent study on this topic, covering metabolic dysfunction, the role of estrogen, and the impact of physical activity. Join me as I explore the complexities of this stage of life and offer practical solutions, including the benefits of exercise and resistance training. Tune in to uncover the science and get actionable insights for managing your health during this transformative period and learn WHY I think microdosing GLP1 agonists can be such a potent tool in this struggle.


On This Episode We Cover:


  • 02:04 - Summarizing the study 
  • 07:01 - Metabolic dysfunction in middle aged women 
  • 10:03 - The importance of physical activity
  • 11:47 - Disease risk and metabolic syndrome 
  • 15:03 - Estrogen, appetite, and physical activity 
  • 19:25 - GLP1s, reward pathways, and movement
  • 22:05 - Insulin resistance, mitochondrial and immune dysfunction  
  • 25:13 - Testosterone and estrogen rations
  • 26:54 - Adipose tissue dysfunction 
  • 28:51 - Obesity, inflammation, and pain 
  • 30:11 - Weight affects people differently 
  • 33:36 - Therapeutic effects of exercise
  • 35:21 - Insulin resistance
  • 37:43 - The importance of resistance training, HIIT, and yoga 
  • 41:52 - Sleep and hormones 
  • 44:35 - Study conclusions

  • Sponsored By:


    • BIOptimizers
    • Go to masszymes.com/drtynafree for your first free bottle of Masszymes
    • Maui Nui
    • Use code DRTYNA for 20% off at mauinuivenison.com

    • Show Links:


      • Adipocyte Metabolism and Health after the Menopause: The Role of Exercise
      • GLP-1s Done Right University Coupon Code: OUVIP


        Further Listening


        • EP. 94: For the Men: Master Your Testosterone | Solo Episode
        • EP. 95: Women Need Testosterone, Too | Solo Episode
        • EP. 104: Fatty Liver 101 | Solo Episode
        • EP 106: Ozempic Done Right Part 1 | Solo Episode
        • EP 107: Ozempic Done Right Part 2 | Solo Episode
        • EP. 109: Ozempic Done Right Part 3 | Solo Episode
        • EP. 129: Ozempic Done Right Part 4: Sustained Weight Loss | Solo Episode
        • EP. 132: Ozempic Done Right Part 5: Osteoarthritis + GLP1 Agonists | Solo Episode

        • Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.

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          The Dr. Tyna ShowBy Dr. Tyna Moore

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