August 18, 2025

This Gene’s a Real MTHFR—Here’s What It’s Doing to Your Body

33 minutes

This episode unpacks the powerful effects of the MTHFR gene mutation—on your heart, liver, brain, and mood. Learn how this tiny genetic hiccup can impact energy, detox pathways, mental health, and longevity—and what to do if you’ve got it.

5 KEY TAKEAWAYS

Heart Disease Connection – MTHFR mutations elevate homocysteine, increasing risk for arterial inflammation, stroke, and dementia.

Liver Strain – MTHFR dysfunction contributes to fatty liver and reduces the body’s ability to detox.

Glutathione Production – The gene impacts your ability to make antioxidants like glutathione and NAC, which protect against oxidative stress.

Mood & Mental Health – MTHFR affects neurotransmitter production, especially serotonin and dopamine, increasing risk of depression and ADHD.

You Need Methyl Donors – Supplements like methylfolate, P-5-P, SAMe, and betaine are crucial to bypass genetic bottlenecks and restore methylation function.

FEATURED PRODUCT

Bliss, featuring SAMe and betaine (trimethylglycine), supports healthy methylation by donating methyl groups—essential for mood, energy, and detox. With sublingual delivery for rapid absorption, Bliss is ideal for those with MTHFR mutations needing extra support for neurotransmitter production, glutathione synthesis, and liver detox. A must-have if you struggle with low mood, brain fog, or inflammation.

Get it here: https://www.mswnutrition.com/products/bliss

TIMESTAMPS

00:00 START – Welcome to the School of Doza

01:00 – Introducing the MTHFR gene and its reputation

02:00 – Genetic testing and what a consult reveals

03:00 – Homocysteine, inflammation, and heart disease

05:00 – Nitric oxide, artery stiffness, and dementia risk

07:00 – Why everyone should test for MTHFR and homocysteine

08:00 – The liver’s overlooked connection to MTHFR

09:30 – How inflammation triggers liver enzymes

11:00 – Why even "normal" genes need lifestyle support

12:00 – Folate (B9) deficiency and its link to depression

13:30 – Personal story: low folate, high homocysteine, and recovery

14:30 – MTHFR, liver enzymes, and antioxidant production

16:00 – Glutathione and NAC: made in the liver, suppressed by MTHFR

18:00 – Methylation, DNA repair, and cancer risk

20:00 – GGT as a liver marker for oxidative stress

21:00 – Neurotransmitters and the B vitamins behind serotonin

22:00 – MTHFR, ADHD, and mental health

23:00 – How Bliss supports brain function and neurotransmitters

25:00 – Methyl donors vs. methylated B12 shots

26:30 – Why Bliss works better for many than other B complexes

27:00 – Research on betaine and SAMe: brain, mood, addiction

30:00 – Methylation and NAD, COMT, and why Bliss helps both

32:00 – Final thoughts: lifestyle can suppress even a “normal” gene

RESOURCES

MTHFR Overview: https://www.ncbi.nlm.nih.gov/books/NBK66131/

Homocysteine and Heart Disease: https://pmc.ncbi.nlm.nih.gov/articles/PMC12027316/

GGT, Liver, and Glutathione: https://pmc.ncbi.nlm.nih.gov/articles/PMC2696075/

Antioxidants and Diabetes Risk: https://pubmed.ncbi.nlm.nih.gov/39442756/

Neurotransmitters and Depression: https://pmc.ncbi.nlm.nih.gov/articles/PMC4750636/

Methyl Donors and Mental Health: https://pmc.ncbi.nlm.nih.gov/articles/PMC10556504/

Betaine for Addiction and Mood: https://www.sciencedirect.com/science/article/abs/pii/S0278584624001611

🔗 CONNECT WITH NURSE DOZA:

JOIN MY SCHOOL for $5: community.schoolofdoza.com/signup

YouTube: https://www.youtube.com/channel/UCwcKyagDi468WscAOWM5VHA

Instagram: https://www.instagram.com/nursedoza/

Website: http://www.nursedoza.com/

LinkedIn: https://www.linkedin.com/in/jonathan-mendoza-dc-aprn-np-c-0609a038/

TikTok: https://www.tiktok.com/@nursedoza

Twitter: https://twitter.com/nursedoza

...more

View all episodes

By NURSE DOZA

4.8

8282 ratings

August 18, 2025

This Gene’s a Real MTHFR—Here’s What It’s Doing to Your Body

33 minutes

This Gene’s a Real MTHFR—Here’s What It’s Doing to Your Body

5 KEY TAKEAWAYS

Heart Disease Connection – MTHFR mutations elevate homocysteine, increasing risk for arterial inflammation, stroke, and dementia.

Liver Strain – MTHFR dysfunction contributes to fatty liver and reduces the body’s ability to detox.

Glutathione Production – The gene impacts your ability to make antioxidants like glutathione and NAC, which protect against oxidative stress.

Mood & Mental Health – MTHFR affects neurotransmitter production, especially serotonin and dopamine, increasing risk of depression and ADHD.

You Need Methyl Donors – Supplements like methylfolate, P-5-P, SAMe, and betaine are crucial to bypass genetic bottlenecks and restore methylation function.