April 18, 2025

Tirzepatide + Metabolic Health: What the Latest Study Really Shows | Solo

48 minutes

EP. 207: A new study on tirzepatide just dropped, and some obesity experts claim it confirms that the drug works only by reducing calories. After reading the full paper myself, I’ve got a different take. In this episode, I unpack what the study actually shows—like how tirzepatide increases fat oxidation without impacting metabolic adaptation—and why the “calories in, calories out” story doesn’t tell the whole truth. There’s more going on here, and you deserve the full picture.

Topics Covered:

Does tirzepatide help with metabolic health beyond calorie restriction leading to weight loss?

How does it affect metabolic adaptation in people with obesity?

Can it boost fat oxidation?

Is the “calories in, calories out” model outdated for GLP-1s?

What does this mean for long-term metabolic health?

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On This Episode We Cover:

00:00:00 – Introduction

00:02:44 – Obesity study on GLP1s and weight loss

00:04:21 – Calories in vs. calories out

00:05:44 – Resting metabolic rate

00:09:25 – Metabolic adaptation during dieting

00:12:11 – Tirzepatide dosing in clinical studies

00:15:49 – Maintaining weight loss

00:18:15 – GLP1s & increased fat oxidation

00:19:14 – GLP1 microdosing myths

00:26:06 – Metabolic rate drops vs. metabolic improvements

00:29:51 – Lessons from the Biggest Loser study

00:34:20 – Study Comparation

00:35:25 – Weight loss, inflammation, and aging

00:36:35 – Health autonomy

00:40:23 – Caloric restriction and the CALERIE study

Studies Mentioned:

Tirzepatide Did Not Impact Metabolic Adaptation In People With Obesity, But Increased Fat Oxidation

Persistent Metabolic Adaptation 6 Years After The Biggest Loser Competition

Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE)

Show Links

GLP-1s Done Right University

Dr. Tyna’s Strength Corner

Metabolic Revamp Toolkit + Masterclass

Further Listening:

GLP1s Uncovered (Free Class)

EP. 202 | The Fight for Affordable GLP1s & the Truth About Big Pharma | Dave Knapp

Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.

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