Question: What can be done about twitching? Short Answer: Most twitching will be driven by glutamate/GABA balance or acetylcholine regulation, and the most likely nutritional issues are any of the electrolytes or any factor that influences energy metabolism. The best way to address it is to consider the conditions that influence it and then trial and error your way through each potential nutritional issue in order of which ones make the most sense for your individual case first. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-phosphatidylcholine In that batch of free episodes you will also find the answers to these questions:

• Phosphatidylcholine and TMAO
• Vitamin K2 and Undercarboxylated Osteocalcin

If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the December 14, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included:

• Inositol, What Is It Good For?
• If I am at risk of heart disease, and phosphatidylcholine raises my TMAO, should I stop the supplement?
• If undercarboxylated osteocalcin (ucOCN) has health benefits and vitamin K2 decreases it, what does that mean for vitamin K2 supplementation?
• Maragen Calcium
• Could slow methylation cause high selenium levels?
• My current thoughts on cholesterol and heart disease
• If I already have oxidative stress, what ducks should I have in a row before supplementing with iron?
• Is it safe to take eight milligrams of zinc daily without copper?
• What to do about developing sensitivities to an increasingly broad range of foods?
• What else to do about hemochromatosis besides phlebotomy?
• If gestational diabetes is just a biotin deficiency, why are women who are insulin resistant prior to pregnancy at higher risk for it, including women with PCOS?
• What to do about chronically elevated amylase and lipase?
• What to do about a non-drinker having very high GGT and occasionally high ALT?
• What are the most common vitamin and mineral deficiencies?
• What are the best supplements, vitamins, and minerals for OCD and depression?
• What is the connection between low pyruvate and high ketones?
• Is high LDL a concern if the carotid IMT and coronary calcium scan are clear?
• Do I trust food allergy tests?

Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-december

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.