Was man teilweise über Vitamin D hört, klingt fast zu schön, um wahr zu sein.
Andererseits deuten hunderte verschiedener Forschungsarbeiten darauf hin, dass Vitamin D zur Vorbeugung einer Reihe von Krankheiten beitragen kann – darunter Osteoporose, Depression, Autoimmun- und Herz-Kreislauf-Erkrankungen.
Ärzte empfehlen es. Gesundheits- und Fitnesspodcaster sprechen darüber. Vielleicht geht Dir sogar Deine Lieblingstante damit auf die Nerven.
Bei all dem Hype ist die Frage berechtigt: "Solltest Du Vitamin D einnehmen?" Hier sind die Antworten – und die neuesten Fakten über ein faszinierendes Vitamin, das ein wahrer Verwandlungskünstler ist.
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Schottker B, Haug U, Schomburg L, et al. Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study. Am J Clin Nutr. 2013 Apr;97(4):782-93.
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Kimball, Samantha M., and Michael F. Holick. 2020. “Official Recommendations for Vitamin D through the Life Stages in Developed Countries.” European Journal of Clinical Nutrition 74 (11): 1514–18.
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Grammatikopoulou, Maria G., Konstantinos Gkiouras, Meletios P. Nigdelis, Dimitrios P. Bogdanos, and Dimitrios G. Goulis. 2020. “Efficacy of Vitamin D3 Buccal Spray Supplementation Compared to Other Delivery Methods: A Systematic Review of Superiority Randomized Controlled Trials.” Nutrients 12 (3). https://doi.org/10.3390/nu12030691.
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Tripkovic, Laura, Helen Lambert, Kathryn Hart, Colin P. Smith, Giselda Bucca, Simon Penson, Gemma Chope, et al. 2012. “Comparison of Vitamin D2 and Vitamin D3 Supplementation in Raising Serum 25-Hydroxyvitamin D Status: A Systematic Review and Meta-Analysis.” The American Journal of Clinical Nutrition 95 (6): 1357–64.
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Logan, Victoria F., Andrew R. Gray, Meredith C. Peddie, Michelle J. Harper, and Lisa A. Houghton. 2013. “Long-Term Vitamin D3 Supplementation Is More Effective than Vitamin D2 in Maintaining Serum 25-Hydroxyvitamin D Status over the Winter Months.” The British Journal of Nutrition 109 (6): 1082–88.
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Vieth, Reinhold. 2020. “Vitamin D Supplementation: Cholecalciferol, Calcifediol, and Calcitriol.” European Journal of Clinical Nutrition 74 (11): 1493–97.6
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Khan, Safi U., Muhammad U. Khan, Haris Riaz, Shahul Valavoor, Di Zhao, Lauren Vaughan, Victor Okunrintemi, et al. 2019. “Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map.” Annals of Internal Medicine 171 (3): 190–98.
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Michos, Erin D., Miguel Cainzos-Achirica, Amir S. Heravi, and Lawrence J. Appel. 2021. “Vitamin D, Calcium Supplements, and Implications for Cardiovascular Health: JACC Focus Seminar.” Journal of the American College of Cardiology 77 (4): 437–49.
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Ushiroyama, Takahisa, Atushi Ikeda, and Minoru Ueki. 2002. “Effect of Continuous Combined Therapy with Vitamin K(2) and Vitamin D(3) on Bone Mineral Density and Coagulofibrinolysis Function in Postmenopausal Women.”Maturitas 41 (3): 211–21.
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Shea, M. Kyla, and Rachel M. Holden. 2012. “Vitamin K Status and Vascular Calcification: Evidence from Observational and Clinical Studies.” Advances in Nutrition 3 (2): 158–65.
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Shea, M. Kyla, Christopher J. O’Donnell, Udo Hoffmann, Gerard E. Dallal, Bess Dawson-Hughes, José M. Ordovas, Paul A. Price, Matthew K. Williamson, and Sarah L. Booth. 2009. “Vitamin K Supplementation and Progression of Coronary Artery Calcium in Older Men and Women.” The American Journal of Clinical Nutrition 89 (6): 1799–1807.
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Masterjohn, Christopher. 2007. “Vitamin D Toxicity Redefined: Vitamin K and the Molecular Mechanism.” Medical Hypotheses 68 (5): 1026–34.
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Deng, Xinqing, Yiqing Song, Joann E. Manson, Lisa B. Signorello, Shumin M. Zhang, Martha J. Shrubsole, Reid M. Ness, Douglas L. Seidner, and Qi Dai. 2013. “Magnesium, Vitamin D Status and Mortality: Results from US National Health and Nutrition Examination Survey (NHANES) 2001 to 2006 and NHANES III.”BMC Medicine 11 (August): 187.
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Uwitonze, Anne Marie, and Mohammed S. Razzaque. 2018. “Role of Magnesium in Vitamin D Activation and Function.” The Journal of the American Osteopathic Association 118 (3): 181–89.
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Johansson, S., and H. Melhus. 2001. “Vitamin A Antagonizes Calcium Response to Vitamin D in Man.” Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research 16 (10): 1899–1905.
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Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. 2011. Dietary Reference Intakes for Calcium and Vitamin D. Edited by A. Catharine Ross, Christine L. Taylor, Ann L. Yaktine, and Heather B. Del Valle. Washington (DC): National Academies Press (US).
- German Nutrition Society. "New reference values for vitamin D." Ann Nutr Metab. 2012;60(4):241-246. doi:10.1159/000337547
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Holick, Michael F., Neil C. Binkley, Heike A. Bischoff-Ferrari, Catherine M. Gordon, David A. Hanley, Robert P. Heaney, M. Hassan Murad, Connie M. Weaver, and Endocrine Society. 2011. “Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline.” The Journal of Clinical Endocrinology and Metabolism 96 (7): 1911–30.
- Robert Koch Institute. 2019. "Wie ist die Vitamin-D-Versorgung in Deutschland?" https://www.rki.de/SharedDocs/FAQ/Vitamin_D/FAQ08.html, Aufruf: 21.10.2024.
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Amrein, Karin, Mario Scherkl, Magdalena Hoffmann, Stefan Neuwersch-Sommeregger, Markus Köstenberger, Adelina Tmava Berisha, Gennaro Martucci, Stefan Pilz, and Oliver Malle. 2020. “Vitamin D Deficiency 2.0: An Update on the Current Status Worldwide.” European Journal of Clinical Nutrition 74 (11): 1498–1513.
- Dierkes, Jutta. 2019. "Vitamin D – eine Übersicht über die Versorgungslage und Gesundheitseffekte" Trillium Diagnostik, Labormanagement Heft 3/2019.
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Parva, Naveen R., Satish Tadepalli, Pratiksha Singh, Andrew Qian, Rajat Joshi, Hyndavi Kandala, Vinod K. Nookala, and Pramil Cheriyath. 2018. “Prevalence of Vitamin D Deficiency and Associated Risk Factors in the US Population (2011-2012).” Cureus 10 (6): e2741.
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Cashman, Kevin D., Tony Sheehy, and Colette M. O’Neill. 2019. “Is Vitamin D Deficiency a Public Health Concern for Low Middle Income Countries? A Systematic Literature Review.” European Journal of Nutrition 58 (1): 433–53.
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Wacker, Matthias, and Michael F. Holick. 2013. “Sunlight and Vitamin D: A Global Perspective for Health.” Dermato-Endocrinology 5 (1): 51–108.
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Forrest, KY, Stuhldreher, WL. Prevalence and correlates of vitamin D deficiency in US adults. Nutr Res. 2011 Jan;31(1):48-54.
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Chalcraft, Jenna R., Linda M. Cardinal, Perry J. Wechsler, Bruce W. Hollis, Kenneth G. Gerow, Brenda M. Alexander, Jill F. Keith, and D. Enette Larson-Meyer. 2020. “Vitamin D Synthesis Following a Single Bout of Sun Exposure in Older and Younger Men and Women.” Nutrients 12 (8). https://doi.org/10.3390/nu12082237.
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Silva, Mariana Costa, and Tania Weber Furlanetto. 2018. “Intestinal Absorption of Vitamin D: A Systematic Review.” Nutrition Reviews 76 (1): 60–76.
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Institute of Medicine, Food and Nutrition Board, and Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. 2011. Dietary Reference Intakes for Calcium and Vitamin D. National Academies Press.
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Wang, Hanmin, Weiwen Chen, Dongqing Li, Xiaoe Yin, Xiaode Zhang, Nancy Olsen, and Song Guo Zheng. 2017. “Vitamin D and Chronic Diseases.”Aging and Disease 8 (3): 346–53.
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Aranow, Cynthia. 2011. “Vitamin D and the Immune System.” Journal of Investigative Medicine: The Official Publication of the American Federation for Clinical Research 59 (6): 881–86.
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Li, Xinyi, Yan Liu, Yingdong Zheng, Peiyu Wang, and Yumei Zhang. 2018. “The Effect of Vitamin D Supplementation on Glycemic Control in Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis.” Nutrients 10 (3). https://doi.org/10.3390/nu10030375.
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Pittas, Anastassios G., Bess Dawson-Hughes, Patricia Sheehan, James H. Ware, William C. Knowler, Vanita R. Aroda, Irwin Brodsky, et al. 2019. “Vitamin D Supplementation and Prevention of Type 2 Diabetes.” The New England Journal of Medicine 381 (6): 520–30.
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Kassi, Eva, Christos Adamopoulos, Efthimia K. Basdra, and Athanasios G. Papavassiliou. 2013. “Role of Vitamin D in Atherosclerosis.” Circulation 128 (23): 2517–31.
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Al Mheid, Ibhar, and Arshed A. Quyyumi. 2017. “Vitamin D and Cardiovascular Disease: Controversy Unresolved.” Journal of the American College of Cardiology 70 (1): 89–100.
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Yin, Lu, José M. Ordóñez-Mena, Tianhui Chen, Ben Schöttker, Volker Arndt, and Hermann Brenner. 2013. “Circulating 25-Hydroxyvitamin D Serum Concentration and Total Cancer Incidence and Mortality: A Systematic Review and Meta-Analysis.” Preventive Medicine 57 (6): 753–64.
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Han, Jianmin, Xiaofei Guo, Xiao Yu, Shuang Liu, Xinyue Cui, Bo Zhang, and Hui Liang. 2019. “25-Hydroxyvitamin D and Total Cancer Incidence and Mortality: A Meta-Analysis of Prospective Cohort Studies.” Nutrients 11 (10). https://doi.org/10.3390/nu11102295.
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Keum, N., and E. Giovannucci. 2014. “Vitamin D Supplements and Cancer Incidence and Mortality: A Meta-Analysis.” British Journal of Cancer 111 (5): 976–80.
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Earthman, C. P., L. M. Beckman, K. Masodkar, and S. D. Sibley. 2012. “The Link between Obesity and Low Circulating 25-Hydroxyvitamin D Concentrations: Considerations and Implications.” International Journal of Obesity 36 (3): 387–96.
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Anglin, Rebecca E. S., Zainab Samaan, Stephen D. Walter, and Sarah D. McDonald. 2013. “Vitamin D Deficiency and Depression in Adults: Systematic Review and Meta-Analysis.” The British Journal of Psychiatry: The Journal of Mental Science 202 (February): 100–107.
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Hughes, D. A., and R. Norton. 2009. “Vitamin D and Respiratory Health.” Clinical and Experimental Immunology 158 (1): 20–25.
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Baktash, Vadir, Tom Hosack, Nishil Patel, Shital Shah, Pirabakaran Kandiah, Koenraad Van den Abbeele, Amit K. J. Mandal, and Constantinos G. Missouris. 2020. “Vitamin D Status and Outcomes for Hospitalised Older Patients with COVID-19.” Postgraduate Medical Journal, August. https://doi.org/10.1136/postgradmedj-2020-138712.
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Carpagnano, G. E., V. Di Lecce, V. N. Quaranta, A. Zito, E. Buonamico, E. Capozza, A. Palumbo, G. Di Gioia, V. N. Valerio, and O. Resta. 2021. “Vitamin D Deficiency as a Predictor of Poor Prognosis in Patients with Acute Respiratory Failure due to COVID-19.” Journal of Endocrinological Investigation 44 (4): 765–71.
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Schwalfenberg, Gerry K. 2011. “A Review of the Critical Role of Vitamin D in the Functioning of the Immune System and the Clinical Implications of Vitamin D Deficiency.” Molecular Nutrition & Food Research 55 (1): 96–108.
