#014- Today we discuss how a process called Keto-flexing can deliver metabolic health. 

Our guest is Ben Azadi, FDN-P who is on a mission to help 1 billion people live a healthier lifestyle. Ben is the author of several best-selling books- The Perfect Health Booklet, The Intermittent Fasting Cheat Sheet, The Power of Sleep, and most recently Keto Flex.  
Ben is the founder of Keto Kamp. He is the go-to source for intermittent fasting and the ketogenic diet. He is known as ‘The Health Detective’ because he investigates dysfunction, and educates, not medicates, to bring the body back to normal function.  

TAKE HOME POINTS:
Keto Flexing is a novel approach to ketogenic nutrition which involves ketosis, fasting, and flexible food choices to optimize the health value of this strategy. 

Ketosis is a normal state in our bodies that we do less and less of because of the American diet, which forces us into the glucose side. So returning to ketosis is not a fad or a particular diet, but it's a way of living. It has health advantages compared to when we burn glucose.  

For ketogenic diet we add fats and oils. It is best to avoid seed/vegetable oils. They are [3 C’s] canola oil, corn oil, cottonseed oil, [3 S’s] soybean oil, sunflower oil, safflower oil, and two others rice bran oil and grapeseed oil. They're very unstable and highly inflammatory. We prefer stable fats, saturated fats, monounsaturated fats such as coconut oil, real olive oil, avocado oil, butter, ghee, duck fat, and lard.  

https://www.benazadi.com/

https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ

https://twitter.com/THEBENAZADI 

https://www.linkedin.com/in/ben-azadi-b7122323/ 

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#013- I’m so sorry! A growing number of physicians have made open apologies for their past recommendations to their patients that encouraged low fat, high carbohydrate meals as a healthy lifestyle choice. 

I want to also add my sincere apologies to all my patients for the wrong advice that I have given over the years when I recommended a low fat diet and largely ignored the dangers of processed foods, seed oils, grains, and refined carbohydrates. 

The accumulated evidence is, in my opinion, overwhelmingly in support of the value of a low carbohydrate diet with limited processed foods, seed oils, and grains.  This is also ideally consumed in fairly narrow eating windows in order to decrease inflammation and insulin resistance while, maximizing metabolic flexibility and autophagy. 

Over the last few years there has been a revolution in our understanding of how major chronic diseases such as obesity, diabetes, hypertension, heart disease, stroke, dementia, and cancers are all linked by underlying longevity processes and most importantly that we can actually influence them through the choices we make in our lives and the primary choice that we can start with is correct diet- what we eat, when we eat, and how much we eat

The wonderful thing about science unlike say religion or politics is that with enough evidence we can all accept new ideas, and admit when we were wrong and change for the better.

As a result I have made this my primary focus to help bring quality evidence based information about health and longevity to the general public through social media, podcasts, video and other presentations such as this. 

I hope that you can join me on this exciting journey to transform our health and our lives!!

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#012-Our guest today is an expert in treating people with heart disease on the operating table who has begun to treat patients with a novel approach before they have a heart attack and arrive on his table. Eighty-eight percent of Americans are metabolically unhealthy -find out to change to lower that number.

Dr. Philip Ovadia is a cardiothoracic surgeon who also has a  practice focused on Metabolic Health and reducing Cardiac Risk.  He is the author of the book 'Stay Off My Operating Table.'

He completed a residency in General Surgery at the University of Medicine and Dentistry at New Jersey, and a Fellowship in Cardiothoracic Surgery at Tufts – New England Medical School.

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#011-Glycans are being hailed as possibly the next great biological longevity clock. Today we speak with the leading expert on the subject.  

Gordan Lauc PhD, is Professor of Biochemistry and Molecular biology at the University of Zagreb and Co-Founder and Chief Scientific Officer at GlycanAge. He graduated from the University of Zagreb Faculty of Science in 1992, and obtained PhD in Biochemistry and the University of Zagreb.

Take home points:

Glycans– the third revolution in evolution

Nuclei acids - 4 building blocks [linear]
Proteins -  20 amino acids [linear]
Glycoproteins- 2000+ [nonlinear]

Examples -Blood groups ABO are glycans

Post translational-make protein 

Glycans modifications of proteins lipids and even DNA by sugar

Nonlinear branching oligosaccharide 

    Glucose-monosaccharide-

Post translational modifications-

     Phosphorylation

     Glycosylation

AGE- advanced glycation end products——reaction glucose and proteins- not the same as glycosylation.

Immunoglobulins- older get more pro inflammatory glycans-

Igg glycosylation suppress inflammation

Human glycan project

Health Longevity Secrets show listeners who wish to try The Glyconage longevity clock on themselves can receive a 20% discount enter the code ROBERTLUFKIN at the glycanage.com website.

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#010-Today we take a look at gene therapy and the possibilities for longevity with someone who is not only an expert in the field but who has also tested the longevity gene therapy on herself. 
Elizabeth Parrish is an entrepreneur and founder and CEO of Bio-Viva Sciences. She is a graduate of the University of Washington. 

Preprint: Telomerase reverse transcriptase (TERT) and follistatin (FST). 
Mouse cytomegalovirus (MCMV) carrying exogenous TERT or FST (MCMVTERT or MCMVFST) extended median lifespan by 41.4% and 32.5%, respectively. First report of CMV being used successfully as both an intranasal and injectable gene therapy system to extend longevity. Jaijyan, Dabbu Kumar, Anca Selariu, Ruth Cruz-Cosme, Mingming Tong, Shaomin Yang, George Church, David Kekich, et al. “New Intranasal and Injectable Gene Therapy for Healthy Life Extension.” Preprint. Cell Biology, June 26, 2021. https://doi.org/10.1101/2021.06.26.449305.
https://www.biorxiv.org/content/10.1101/2021.06.26.449305v1.full.pdf 

https://bioviva-science.com/

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#009-Ayruvedic medical traditions going back over 5000 years have a lot to say about approaches to preventing memory loss that have many fascinating similarities to the latest thinking about Alzheimer’s disease prevention.

Today we are joined by by someone who is not only an expert in the latest neuroscience and biochemistry of Alzheimer’s disease but is also an expert in Ayurveda.

Dr. Rammohan Rao is Principal Research Scientist at Apollo Health. He has a Ph.D. in neuroscience and biochemistry and has worked closely with Dr. Dale Bredesen at the Buck Institute for Research on Aging where he was an Associate Professor of Neuroscience focusing in the areas of chronic stress, neuronal cell death, and mechanisms of age-associated neurodegenerative diseases with special emphasis on Alzheimer’s disease.

Dr. Rao has over twenty-five years of research and teaching experience in neuroscience and has published more than 50 peer-reviewed papers in scientific journals and chapters in several textbooks.  He is also a National Ayurveda Medical Association (NAMA) board-certified Ayurveda Practitioner and a Registered Yoga Teacher (RYT-200) from Yoga Alliance USA and teaches Ayurveda and Yoga at the California College of Ayurveda.

Take home points:

-Ayurveda- Science of Life

-Network approach to disease rather than targeted drug approach

-Diet, herbs, aroma, lifestyle, yoga, meditation

-Mind and digestive system two main components

-Prevention strategies for memory loss

-AHARA- healthy diet- 12 hour overnight fast, no between meal snacks

-JATHARAGNI-Digestive fire

-NIDRA- sleep

-PANCHAKARMA- detoxification, purification, rejuvenation

-ABHYANGA-oil herb massage

-Herbs- Ashwagandha, Turmeric/Curcumin, gotu kola

-Brain exercises

-ACHARA-routines 

https://www.apollohealthco.com/apollo-health-welcomes-ram-rao-ph-d-as-our-principal-research-scientist/

https://www.ayushliving.com/united-states/concord/practitioners/dr-rammohan-rao

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#009-Stress is now known to affect everything from gray hair to epigenetic age among other things in our health.  Dr Stephen Sideroff beautifully outlines the 9 pillars of resiliency that allow us to handle the inevitable chronic stress in our lives.

Please join Dr Stephen Sideroff for this masterclass in human stress management through building lasting resilience.

Take away points: 

-Stress can be both positive and negative. Chronic stress tends to be harmful.

 -Stress can affect telomeres and other markers for aging

-Early childhood experiences can strongly influence how we deal with stress as adults

03:38 Steve's early career in brain research

06:04 Failure of longterm results in stress management from single workshop

08:24 Early childhood experiences and the primitive gestalt effect on stress

14:23 Enhancing neuroplasticity

18:00 The path: mastering the nine pillars of resilience

24:12 Stress effect on telomeres and markers for aging

30:15 Concept of eustress for positive stress from Hans Selye

37:23 Key pillars of resilience

40:45 Relationship with ourselves, others, and something greater

41:52  John M. Gottman ratio of positive to negative couples interactions

45:03 Stress as sympathetic nervous system activator

48:21 Personal lifestyle choices

http://drstephensideroff.com/  

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#008-The physician with arguably the largest clinical experience in prescribing Rapamycin for longevity talks about the challenges and benefits of this fascinating and controversial practice. Dr Alan Green takes us on a deep dive on the use of Rapamycin for longevity.

Take away points: 
-Rapamycin has extended the lifespan of organisms from yeast, worms, flies, and even middle-aged mice.
-In a 2014 paper, rapamycin extended the median lifespan 23% in male mice and 26% in female mice. 
-It is an FDA approved prescription drug with indications for use for the prevention of organ transplant rejection and for the treatment of lymphangioleiomyomatosis.
-The drug requires a prescription and should only be used under supervision of a physician
-Rapamycin acts by suppressing the master nutrient sensing protein mTOR [mechanistic target of Rapamycin]


02:45 Blagosklonny papers (Blagosklonny 2019)
05:23 Jane Mannick rapalogue paper (Mannick 2014)
08:04 Cardiomyopathy diagnosis : Apical hypertrophic cardiomyopathy
09:14 Elevated mTOR as common factor- Inflammation, fibrosis, 
12:03 Rapamycin role to decrease mTOR overview common pathway 
14:23 mTOR is essentially command and control of the cell for the last 2 billion years
15:00 Mitochondrial complex 1 affected by common pathway by rapamycin, caloric restriction, protein restriction, methionine restriction has universal anti-aging effects
16:05 Increased mTOR causes increased innate immune system/inflammation 
17:28 2009 paper showed increased mouse lifespan not by just decreasing cancer but most other diseases of aging
19:15 Osteoarthritis inflammation improved by decreased mTOR and increased autophagy 
23:00 Alzheimer disease as a disease of senescent cells
26:00 importance of dose timing for Rapamycin
27:00 Anti aging effects on mTOR1 and other effects on mTOR2
32:00 Rapamycin as off patent drug
37:00 Dosing considerations and subjective effects
40:00 Tracking HOMA-IR  (Homeostatic Model Assessment for Insulin Resistance) score 
42:00 Improvement in exercise related to maximum cardiac output
45:00 Age associated cardiomyopathy
49:00 Untoward effects- Aphthous ulcers and decreased innate immune system. Be on guard for bacterial infections.
57:00 Personal lifestyle choices

https://rapamycintherapy.com/ 

Rapamycin Clinical Registry
https://www.rapamycin.io/

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#007-Magnetic resonance or MR  imaging is one of the most powerful noninvasive medical testing tools- and when we combine it with with the emerging power of artificial intelligence great things are possible. Today we are looking specifically at applying this technology to the brain  in order to help understand dementia from one of the leaders in the field. 

Wiro Niessen is a professor at both Erasmus MC, University Medical Center Rotterdam and Delft University of Technology. He is founder and scientific lead of Quantib, an AI company in medical imaging. He received a master's degree in Physics and a PhD in Medical Imaging from Utrecht University.

—2012 ImageNET competition revolutionized machine learning with deep convolutional neural networks

-Data science approach to medical imaging

-How risk factors [Genetic and lifestyle] are associated with outcome

-Rotterdam study for population imaging

-Increased deep white matter changes associated with increased stroke and dementia

-DTI- diffusion tensor imaging allows white matter tracts to be seen- AI can automate processing to save orders of magnitude in processing time

-Automated biomarker extraction from 15,000 Brain MRI

-Hippocampal volume- associated with risk for later developing Alzheimer disease. 

-MICCAI Society- Medical Image Computing and Computer Assisted Interventions

-ESR- European Society of Radiology

-FAIR- Finable, Accessible, Interoperable, Reusable Data

https://www.erasmusmc.nl/en/research/researchers/niessen-wiro

https://www.quantib.com/about/team/wiro-niessen

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#006-Epigenetic change is now recognized as the cumulative effect of our life experiences in controlling gene expression. What is less well known is that this epigenetic influence on our gene expression can extend back to our parents’ and even our grandparents’ life experiences. Let's dive into this fascinating topic with todays guest expert.

Judith Finlayson is a best-selling author who has written books on a variety of subjects, from personal well-being and women’s history to food and nutrition. Her most recent book ‘You Are What Your Grandparents Ate’ is a revealing take on transgenerational epigenetics and has been translated into German, French, Spanish, Slovenian and Japanese. 

Key points:

-Current understanding - genomic information is transferred but epigenetic information is wiped clean each generation-but not quite so simple. 

-For example, studies have shown that both the children and grandchildren of women who survived the Dutch famine of 1944-45 were found to have increased glucose intolerance in adulthood.

-Other researchers have found that the descendants of Holocaust survivors have lower levels of the hormone cortisol, which helps your body bounce back after trauma.

-Mechanisms for transgenerational epigenetics

-David Barker- hypothesis

-dietary and lifestyle choices she prioritizes to support optimal genetic expression. 

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