#005-Today we learn how diet, genetics, and epigenetics interact with each other to impact our health and longevity, and how to use this information to design personalized lifestyle interventions from a true expert in the field.

Dr. Lucia Aronica received her PhD from the University of Vienna and has research experience from the University of Oxford, University of Southern California, and University Federico II of Naples. She is also Lecturer at the Stanford Prevention and Research Center, Genomics Lead at Metagenics Inc., and editor of the peer-reviewed journal Life by MDPI. 

Take away points: 
-We get our genetic information from our ancestors while epigenetic information is from our life experiences
-Epigenetic change can occur via three mechanisms: 1- small RNA, 2-histone modification, and 3-DNA Methylation
-DNA Methylation is currently the best epigenetic modification for detailed epigenetic analysis
-First generation DNA methylation clocks (Horvath et al) were chronological clocks, while second generation clocks (GrimAge, etc) tend to be biological clocks trained on specific conditions/phenotype
-Chronological clocks are useful in forensic applications
-Chronological age can deviate from biological age reflecting varying risk for outcomes
-Athletes showing increased biological age may be related to short term inflammatory genes and cytokines for the adaptive stress response to exercise
-In Ketogenic diets can see down regulation of excitatory brain pathways as possible mechanism for effects in epilepsy population
-Induced pleuripotent stem cells can be produced by transcription factors that reverse epigenetic age
-Biologic DNA methylation clocks are very valuable for lifestyle intervention and longevity research

[email protected] 

https://draronica.com/

https://www.youtube.com/user/81luxar

https://continuingstudies.stanford.edu/courses/liberal-arts-and-sciences/longing-for-longevity-from-biology-to-biohacking/20211_BIO-07 

Gardner CD, Kiazand A, Alhassan S, Kim S, Stafford RS, Balise RR, Kraemer HC, King AC. Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomized trial. JAMA. 2007 Mar 7;297(9):969-77. doi: 10.1001/jama.297.9.969. Erratum in: JAMA. 2007 Jul 11;298(2):178. PMID: 17341711.

*** SUBSCRIB

Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/
Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/
Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin
At home blood testing (20% off) https://siphoxhealth.com/lufkin
Mimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611

Web: https://robertlufkinmd.com/
X: https://x.com/robertlufkinmd
Youtube: https://www.youtube.com/robertLufkinmd
Instagram: https://www.instagram.com/robertlufkinmd/
LinkedIn: https://www.linkedin.com/in/robertlufkinmd/
TikTok: https://www.tiktok.com/@robertlufkin
Threads: https://www.threads.net/@robertlufkinmd
Facebook: ...

#004-Up to 40% of dementia may be prevented through lifestyle changes [Livingston Lancet 2020]. Let's find out the top six ways to reduce dementia risk with lifestyle from todays expert guest.

Sarah McEwen, PhD, is a Cognitive Psychologist with 15 years of clinical research experience, specializing in the study of physical activity and cognitive enhancement interventions to investigate biological, behavioral and health-related outcomes in patients suffering from cognitively debilitating disorders. 

Dr. McEwen graduated with a bachelor’s degree from the University of California, Davis and a PhD in Psychology from Trinity College.

Dr. McEwen serves as Section Editor for the peer-reviewed journal NeuroReport, and Associate Editor for the Journal of Alzheimer’s Disease, and has published over 45 peer-reviewed journal articles. 

Up to 40% of dementia may be prevented through lifestyle changes [Livingston Lancet 2020]. 

Neuroplasticity - brain can change throughout life

-Physical exercise can actually result in hipoocampal growth on MRI in adults. 

-Diet- Follow the MIND protocol

-Sleep

-Reduce chronic stress-MBSR Mindfulness Based Stress Reduction

     Hippocampal volumes can increase following MSSR [Holzel 2011]

https://wakingup.com/ 

https://palousemindfulness.com/ 

-Social Isolation

Genius Gyms  (https://geniusgyms.com)

Pacific Brain Health Center (https://www.pacificneuroscienceinstitute.org/brain-health/) 

*** SUBSCRIBE TO ROBERT LUFKIN MD YOUTUBE CHANNEL HERE ***https://www.youtube.com/channel/UC2w2eKHmcRXuGR8RmTgUv3Q

*** CONNECT WITH ROBERT LUFKIN MD ON SOCIAL MEDIA ***Web: https://robertlufkinmd.com/Twitter:https://twitter.com/robertlufkinmdLinkedIn: https://www.linkedin.com/in/robertluf...

*** THINGS I ACTUALLY USE FOR MY OWN HEALTH AND LONGEVITY ***[ROBERT LUFKIN MD AMAZON INFLUENCER STOREFRONT]https://www.amazon.com/shop/robertluf...

*** GOT A SUGGESTION FOR A SHOW? ***Contact us at: https://robertlufkinmd.com/contact

*** SPONSORSHIPS & BRANDS ***We do work with sponsors and brands. If you are interested in working with us and you have a product or service that is of value to the health industry please contact us at: https://robertlufkinmd.com/contact 

NOTE: This is not intended to be a substitute for professio

Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/
Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/
Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin
At home blood testing (20% off) https://siphoxhealth.com/lufkin
Mimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611

Web: https://robertlufkinmd.com/
X: https://x.com/robertlufkinmd
Youtube: https://www.youtube.com/robertLufkinmd
Instagram: https://www.instagram.com/robertlufkinmd/
LinkedIn: https://www.linkedin.com/in/robertlufkinmd/
TikTok: https://www.tiktok.com/@robertlufkin
Threads: https://www.threads.net/@robertlufkinmd
Facebook: ...

#003-A new MRI company with a technological twist and a revolutionary vision to transform health and longevity by low cost MR screening for cancer and other diseases. Co-founders Raj Attariwala MD and Andrew Lacy MBA JD describe their fascinating journey and the challenges of early detection of disease. 

Take away points: 
-Cancer and other disease are 5-7 times more likely to kill you if detected late.
- A late diagnosis of a serious health condition often leads to a much worse outcome.
-Conditions such as aneurysms, dementia, stroke risk, IBD, colitis, kidney stones do not have very effective screening tests.
-Due to cost pressures in the health system, doctors may be discouraged from investigating low probability diagnoses, even if they have serious consequences for the patient. 


https://www.prenuvo.com/ 

https://omronhealthcare.com/products/heartguide-wearable-blood-pressure-monitor-bp8000m/

*** SUBSCRIBE TO ROBERT LUFKIN MD YOUTUBE CHANNEL HERE ***https://www.youtube.com/channel/UC2w2eKHmcRXuGR8RmTgUv3Q

*** CONNECT WITH ROBERT LUFKIN MD ON SOCIAL MEDIA ***Web: https://robertlufkinmd.com/Twitter:https://twitter.com/robertlufkinmdLinkedIn: https://www.linkedin.com/in/robertluf...

*** THINGS I ACTUALLY USE FOR MY OWN HEALTH AND LONGEVITY ***[ROBERT LUFKIN MD AMAZON INFLUENCER STOREFRONT]https://www.amazon.com/shop/robertluf...

*** GOT A SUGGESTION FOR A SHOW? ***Contact us at: https://robertlufkinmd.com/contact

*** SPONSORSHIPS & BRANDS ***We do work with sponsors and brands. If you are interested in working with us and you have a product or service that is of value to the health industry please contact us at: https://robertlufkinmd.com/contact 

NOTE: This is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have. Never disregard professional medical advice or delay in seeking it because of something you have seen here.

Robert Lufkin MD may at any time and at its sole discretion change or replace the information available on this channel.

To the extent permitted by mandatory law, Robert Lufkin MD shall not be liable for any direct, incidental, consequential, indirect or punitive damages arising out of access to or use of any content available on this channel, including viruses, regar

Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/
Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/
Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin
At home blood testing (20% off) https://siphoxhealth.com/lufkin
Mimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611

Web: https://robertlufkinmd.com/
X: https://x.com/robertlufkinmd
Youtube: https://www.youtube.com/robertLufkinmd
Instagram: https://www.instagram.com/robertlufkinmd/
LinkedIn: https://www.linkedin.com/in/robertlufkinmd/
TikTok: https://www.tiktok.com/@robertlufkin
Threads: https://www.threads.net/@robertlufkinmd
Facebook: ...

#002 - I was raised on margarine, diet soda, low-fat milk, and I avoided sugary cereals. We followed the guidelines of the USDA and the Food Pyramid. How did we get it so wrong? Find out as we meet an experienced dietician and high performance athlete who is rethinking the conventional wisdom on nutrition.

Michelle Hurn is a registered and licensed dietitian with eleven years of experience as a clinical, acute care dietitian, lead dietitian in psychiatric care, and outpatient dietitian.
She is the author of The Dietician's Dilemma-What would you do if your health was restored by doing the opposite of everything that you were taught?
Michelle is an avid endurance athlete, she has qualified for the Boston Marathon 12 times, and on November 7th 2020, she recently won her first ultra marathon covering 44.63 miles in a 6 hour timed race.

Some of the things we cover:

What is a dietician and what do they do?

What is the state of modern dietetics? 

What does the ADA still get wrong today?

What are your current recommendations?

Optimal diet?

Fasting?

https://thedietitiansdilemma.net/

https://www.robertlufkinmd.com/

Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/
Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/
Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin
At home blood testing (20% off) https://siphoxhealth.com/lufkin
Mimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611

Web: https://robertlufkinmd.com/
X: https://x.com/robertlufkinmd
Youtube: https://www.youtube.com/robertLufkinmd
Instagram: https://www.instagram.com/robertlufkinmd/
LinkedIn: https://www.linkedin.com/in/robertlufkinmd/
TikTok: https://www.tiktok.com/@robertlufkin
Threads: https://www.threads.net/@robertlufkinmd
Facebook: ...

#001 - It is becoming accepted that most major chronic illnesses are linked by common metabolic/longevity mechanisms that can be influenced by the choices we make in our lives. Let’s use evidence based medicine to inform these choices.  

This is a quick first episode of the show where we describe the motivation for the program and a brief overview of the types of experts on health and longevity that we will can expect to see. This program is part of my continuing effort to bring quality evidence based health and longevity information to the general public to help inform these choices.  We hope that you enjoy the program. Please join our family and hit subscribe!

https://www.robertlufkinmd.com/

Lies I Taught In Medical School : Free sample chapter- https://www.robertlufkinmd.com/lies/
Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/
Fasting Mimicking Diet (20% off) https://prolonlife.com/Lufkin
At home blood testing (20% off) https://siphoxhealth.com/lufkin
Mimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611

Web: https://robertlufkinmd.com/
X: https://x.com/robertlufkinmd
Youtube: https://www.youtube.com/robertLufkinmd
Instagram: https://www.instagram.com/robertlufkinmd/
LinkedIn: https://www.linkedin.com/in/robertlufkinmd/
TikTok: https://www.tiktok.com/@robertlufkin
Threads: https://www.threads.net/@robertlufkinmd
Facebook: ...