Infectious Disease Puscast

On episode #48 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 1/31 – 2/13/24.

Hosts: Daniel Griffin and Sara Dong

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• Viral
• Infectious attenuated tetravalent Butanatan-Dengue vaccine (NEJM)
• Kids with severe disease following first and second dengue virus infection (Nature)
• Oropouche fever outbreak in Latin America (Lancet Infectious Diseases)
• CMV mRNA vaccine knocks out gB/MF59 vaccine (JID)
• Acyuclovir-resistant mucocutaneous HSV in immunocompromised patients (OFID)
• Bacterial
• Dalbavancin for vertebral osteomyelitis (OFID)
• Severe vibrio vulnificus infections (MMWR)
• Demystifying UTIs in the era of antibiotic resistance (PLoS Pathogens)
• Syphilis testing recommendations (MMWR)
• Doxycycline vs azithromycin for scrub typhus (BMC Infectious Diseases)
• REALLY drug resistant Pseudomonas aeruginosa outbreak(CID)
• Fungal
• SUBA or conventional itraconazole for treatment of endemic mycoses (OFID)
• Fluconazole resistant Candida (CDC)
• Are you in the hospital too long after being treated with echinocandin for your Candidemia or invasive Candidiasis (OFID)
• Nasopharyngeal swab or lower respiratory tract specimen for Pneumocystis jirovecii diagnosis (OFID)
• Global guideline for cryptococcosis diagnosis and management (Lancet Infectious Disease)
• Parasitic
• Toxoplasma IgG positivity associates with increase mortality (AJTMH)
• Miscellaneous
• How well did infectious diseases fellows match (JID)
• Back to the future of the physician-scientist in infectious diseases (JID)
• Full or not infectious disease training (JID)

Music is by Ronald Jenkees

On episode #46 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 1/18 – 1/31/24.

Hosts: Daniel Griffin and Sara Dong

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• Viral
• Reinfection by Zika via genome diversity and antibody response (EID-Emerging Infectious Disease)
• People with HIV should breast/chest feed (CID)
• Norovirus GII in the water (PLoS Water)
• Herpes zoster and duloxetine premedication for neuralgia (CID)
• Bacterial
• SABATO: early oral switch trial (Lancet)
• Guideline for concordant antibiotic therapy to treat community-acquired pneumonia (Chest)
• Ceftriaxon with or without Nafcillin/Oxacillin for MSSA treatment (OFID)
• Ceftriaxone to prevent ventilator-associated pneumonia trial (Lancet)
• Azithromycin part of routine well-infant visits (NEJM)
• Burkholderia pseudomallei in Mississippi(NEJM)
• Cefiderocol red wine urine syndrome in children (Pediatric Infectious Disease Journal)
• Fungal
• InsuranceClaims equals blastomycosis Incidence (EID)
• Antimicrobial stewardship for coccidioidomycosis in endemic region (OFID)
• Endemic mycosesafter solid organ transplantation (OFID)
• Parasitic
• Headbobbing trematoda (CMI)
• Miscellaneous
• Suspected hemophagocytic lymphohistiocytosis (JPIDS)
• BioFire FilmArray for real-life assessment of hospitalized respiratory illness (JID)
• Clinical microbiology conferences gender and geography (Lancet)
• Is the toilet really the greatest sanitation invention? (AJICJ)

Music is by Ronald Jenkees

On episode #46 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 1/4 – 1/17/24.

Hosts: Daniel Griffin and Sara Dong

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• Comparing the performance of three models incorporating weather data to forecast dengue epidemics (JID)
• Elucidating the impacts of climate on dengue transmission through mathematical models (JID)
• Infants receiving a single dose of nirsevimab to prevent RSV do not have evidence of enhanced disease in their second RSV season (JPIDS)
• Patient perspectives on solid organ transplantation from donors with hepatitis C viremia to recipients without hepatitis C viremia (OFID)
• Oral Beta-Lactams, Fluoroquinolones, or Trimethoprim-Sulfamethoxazole for definitive treatment of uncomplicated Escherichia coli or Klebsiella species bacteremia from a urinary source (OFID)
• Discontinuation of contact precautions for methicillin-resistant Staphylococcus aureus in a pediatric healthcare system (JPIDS)
• Oral linezolid compared with benzathine PCN G for treatment of early syphilis in adults (The Lancet)
• Model-informed precision dosing improves outcomes in patients receiving vancomycin for gram-positive infections (OFID)
• The Xpert MTB/RIF cycle threshold value predicts M.tuberculosis transmission to close contacts (CID)
• Efficacy and safety of a structured de-escalation from antipseudomonal β-lactams in bloodstream infections due to Enterobacterales (The Lancet)
• Oral antibiotics for treatment of Gram negative bacteremia in solid organ transplant recipients (CID)
• Dematiaceous fungal keratitis with tentacles mimicking Pythium Keratitis (Jama)
• Verification, analytical sensitivity, cost-effectiveness, and comparison of four Candida auris screening methods (OFID)
• Tafenoquine-Atovaquone combination achieves radical cure and confers sterile immunity in experimental models of human babesiosis (JID)
• Relapsing babesiosis with molecular evidence of resistance to certain antimicrobials commonly used to treat Babesia microti infections (OFID)
• Understanding parental leave policies in ID fellowship (OFID)
• What's hot this year in ID clinical science (CID)

Music is by Ronald Jenkees

On episode #45 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 12/20/23 – 1/3/24.

Hosts: Daniel Griffin and Sara Dong

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• Notes coming soon
• Bacterial
• Change in oral PrEP affect kidney function (OFID)
• Preventing STIs in women (NEJM)
• Revising antibiotic and STI trials (NEJM)
• Treatment for pediatric febrile UTIs (Pediatrics)
• Burkholderia pseudomallei in Mississippi (NEJM)
• Acute kidney injury and gentamicin treatment for endocarditis (JACAMR)
• Pacemakers for Lyme disease patients (OFID)
• Pseudomonas aeruginosa update and must have references (CMI)
• Fungal
• Definining optimal dose liposomal amphotericin B for Candida auris (JID)
• Cryptococcus neoformans and HIV serology (OFID)
• Global emergence of Candida auris (OFID)
• Novel anti-cancer therapeutics and fungal biology (PLoS Pathogens)
• Parasitic
• Second malaria vaccine prequalified (WHO)
• Seasonal vaccination against malaria in children (Lancet ID)
• Toxoplasma gondii treatement guidelines for patients with haematological malignancies (Lancet ID)
• Miscellaneous
• Eye infection review (NEJM)
• Diagnosing children with gastroenteritis using molecular testing (CID)
• Are hospital coffee machines pathogenic (BMJ)
• Putting down the fluoroquinolone (CID)

Music is by Ronald Jenkees

On episode #44 of the Infectious Disease Puscast, Sara reviews the infectious disease literature for the weeks of 12/8 – 12/20/23.

Hosts: Daniel Griffin and Sara Dong

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• Mpox and chickenpox co-infection (J Inf Dis)
• Corticosteroids for postherpetic neuralgia (Coch Data Syst Rev)
• Dengue incidence and mortality in Bangladesh (J Inf Dis)
• ACORN trial vancomycin and piperacillin-tazobactam (Open For Inf Dis)
• Models for infection risk in children with cancer (J Clin Oncol)
• Salmonella outbreak from cantaloupes (CDC)
• Pediatric antimicrobial stewardship programs ( Ped Inf Dis Soc)
• MRSA nasal swab PCR assay (J Ped Inf Dis Soc)
• Invasive meningococcal disease (Open For Inf Dis)
• Probiotics for recurrent UTI (Clin Inf Dis)
• Preservation fluid contamination and kidney transplant patients (Transpl Inf Dis)
• Mechanism of zinc prevention of candidiasis (Sci Transl Med)
• Risk factors for invasive fungal infection (Open For Inf Dis)
• Genetic variants associated with S. mansoni worm burden (PLoS NTD)
• Chagas disease GI manifestations (Am J Trop Med Hyg)
• Wolbachia in Aedes aegypti in Colombia (PLoS NTD)

Music is by Ronald Jenkees

On episode #43 of the Infectious Disease Puscast, Sara reviews the infectious disease literature for the weeks of 11/22 – 12/06/23.

Host: Sara Dong

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• Treatment for first cytomegalovirus infection post-hematopoietic cell transplant (CID)
• Mortality among children aged antiretroviral treatment (CDC)
• Boostability after single-visit pre-exposure prophylaxis with rabies vaccine (The Lancet)
• Alarming trends in dengue incidence and mortality in Bangladesh (JID)
• Update on cardiovascular implantable electronic device infections and their prevention, diagnosis, and management (Circulation)
• SCCM/IDSA guidelines for evaluating new fever in adult patients in the ICU (IDSA)
• Risk factors for serogroup B meningococcal disease among college students (OFID)
• Comparison of Adjuvant Clindamycin vs Linezolid for severe invasive Group A Streptococcal skin and soft tissue infections (OFID)
• State of the art reviews: Persistent enterococcal bacteremia (CID)
• Billirud Mill Blastomycosis outbreak (MM)
• Primaquine radical cure in patients with P.falciparum malaria in areas co-endemic for P falciparum and P vivax (The Lancet)
• Microbiology, public health, and the murals of Diego Rivera (CID)

Music is by Ronald Jenkees

On episode #42 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 11/09 – 11/21/23.

Host: Daniel Griffin and Sara Dong

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• Progress toward measles elimination (CDC)
• Slaying the troll of transplantation (TID)
• Association between the neutrophil-to-lymphocyte ratio and adverse outcomes in children aged
• Pre-exposure prophylaxis use history in people with antiretroviral resistance at HIV diagnosis (CID)
• Impact of the 2019 FDA guidance for uncomplicated UTI on treatment response rates (OFID)
• CDC Guidelines for the prevention and treatment of anthrax (CDC)
• Contemporary use of cefazolin for MSSA infective endocarditis (IJID)
• Is carbapenem therapy necessary for treatment of non-CTX-M ESBL-producing Enterobacterales bloodstream infections (CID)
• Infectious diseases consultation associated with reduced mortality in gram-negative Bacteremia (CID)
• Contemporary management of Staphylococcus aureus bacteremia (CID)
• Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal (Nature)
• Impact of in-house Candida auris PCR screening on admission on the incidence rates of surveillance and blood cultures with C. auris and associated cost savings (OFID)
• Human lobomycosis caused by Paracoccidioides loboi (EID)
• Molecular surveillance detects high prevalence of the neglected parasite Mansonella ozzardi (JID)
• Efficacy and safety of moxidectin compared with ivermectin against Strongyloides stercoralis infection in adults (The Lancet)
• Efficacy of bortezomib for treating anti-interferon-gamma autoantibody-associated adult-onset immunodeficiency (AOID) syndrome (CID)
• Investigational non-antibiotic therapeutics for infections in hematopoietic cell transplant recipients and patients with hematologic malignancies receiving cellular therapies (TID)
• Black box warning: large language models and the future of infectious diseases consultations (CID)

Music is by Ronald Jenkees

On episode #41 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 10/26 - 11/08/23.

Host: Daniel Griffin and Sara Dong

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• Intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and Omicron BA.2 variant in Hong Kong (JID)
• Efficacy and safety of corticosteroid therapy for community-acquired pneumonia (CID)
• Hydrocortisone in severe community-acquired pneumonia (NEJM)
• Early oral antibiotic switch in Staphylococcus aureus bacteraemia (CID)
• Outbreak of invasive Group A Streptococcus in children (PIDS)
• Inhaled amikacin to prevent ventilator-associated pneumonia (NEJM)
• Assessing risk for complications in acute hematogenous osteomyelitis in children (JPIDS)
• Empirical antibiotic therapy in diabetic foot ulcer infection increases hospitalization(OFID)
• 2023 guideline on diagnosis and management of acute bacterial arthritis in pediatrics (JPIDS)
• Natural history of antibiotic-treated lower limb cellulitis (OFID)
• Missed opportunities for preventing congenital syphilis (CDC)
• Diverse clinical manifestations and challenges of mucormycosis (OFID)
• Malaria (The Lancet)
• Clinical characteristics and outcomes of Chagas disease (AJTMH)
• Direct gloving vs hand hygiene before donning gloves in adherence to hospital infection control practices (JAMA)
• How I approach diarrhea in hematological transplant patients (TID)
• Innovating pediatric infectious diseases recruitment and training (JPIDS)

Music is by Ronald Jenkees

On episode #40 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the weeks of 10/13 – 10/25/23.

Host: Daniel Griffin and Sara Dong

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• Sustained viral suppression with dolutegravir monotherapy over 192 weeks in patients starting combination antiretroviral therapy during primary HIV infection (CID)
• Dolutegravir monotherapy possibly boosted by highly active natural immunity (CID)
• Mpox neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination (The Lancet)
• Linezolid population pharmacokinetic model in plasma and cerebrospinal fluid among patients with tuberculosis meningitis (JID)
• Adjunctive dexamethasone for tuberculous meningitis in HIV-positive adults (NEJM)
• Cefepime vs piperacillin-tazobactam in adults hospitalized with acute infection (JAMA)
• Acute kidney injury with empirical antibiotics for sepsis (JAMA)
• Mycobacterium abscessus outbreak related to contaminated water among ventilator-dependent residents of a pediatric facility (CDC)
• Trial of Vancomycin and Cefazolin as surgical prophylaxis in arthroplasty (NEJM)
• Trimethoprim-sulfamethoxazole significantly reduces the risk of nocardiosis in solid organ transplant recipients (CMI)
• Risk of hematologic cancers among individuals tested for Borrelia burgdorferi antibodies, and Borrelia burgdorferi seropositive individuals (CMI)
• In vitro susceptibility patterns for slowly growing non-tuberculous mycobacteria (JAC)
• Real-world use of mold-active triazole prophylaxis in the prevention of invasive fungal diseases (OFID)
• Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19 (INI)
• Real-time dermoscopy of numerous mites crawling on the crusted scabies (CMI)
• The African eye worm: current understanding of the epidemiology, clinical disease, and treatment of loiasis (The Lancet)
• Decolonization in nursing homes to prevent infection and hospitalization (NEJM)
• Can chatbot artificial intelligence replace ID physicians in the management of bloodstream infections (CID)
• Nasal iodophor antiseptic vs nasal mupirocin antibiotic in the setting of chlorhexidine bathing to prevent infections in ICUs (JAMA)
• FDA Approves PENBRAYATM for the prevention of the five most common serogroups causing meningococcal disease in adolescents (Pfizer)

Music is by Ronald Jenkees

On episode #39 of the Infectious Disease Puscast, recorded at IDWeek in Boston, Daniel and special host Priya Kodiyanplakkal review the infectious disease literature for the weeks of 9/27 – 10/12/23.

Host: Daniel Griffin and Priya Kodiyanplakkal

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• Survival from rabies in a young child from India (AJTMH)
• The perils of overly-sensitive viral load testing for persons living with HIV (OFID)
• Letermovir vs Valganciclovir for prophylaxis of Cytomegalovirus in high-risk kidney transplant recipients (JAMA)
• Frailty and survival in the 1918 influenza pandemic (PNAS)
• Adverse pregnancy outcomes among HIV-infected Women taking isoniazid preventive therapy during the first trimester (CID)
• Ceftobiprole for treatment of complicated Staphylococcus aureus bacteremia (NEJM)
• Real-world application of oral therapy for infective endocarditis (CID)
• Efficacy and safety of sulbactam–durlobactam versus colistin for the treatment of patients with serious infections (The Lancet)
• Information delay of significant bloodstream isolates and patient mortality (CID)
• Critical appraisal beyond clinical guidelines for intra-abdominal candidiasis (CC)
• Update on outbreak of fungal meningitis among Americans who received epidural anesthesia at clinics in Mexico
• Increasing prevalence of artemisinin-resistant HRP2-negative malaria in Eritrea (NEJM)
• Gender differences in psychosocial determinants of hand hygiene among physicians (ICHE)

Music is by Ronald Jenkees