What do you really know about the theory of aging?

In this episode of the Biohacking Superhuman Performance podcast, we chat with Dr. Sandra Kaufman about the critical functions of SIRT1 and SIRT3 in our bodies, spotlighting how these proteins are not only gatekeepers of DNA repair and mitochondrial efficiency but also promising targets in the quest to combat aging.

We dissect the intricacies of supplement bioavailability, pitting resveratrol against its molecular cousin pterostilbene. Dr. Kaufman demystifies recent findings and navigates us through state-of-the-art delivery methods that are revolutionizing the way our bodies absorb these longevity-boosting substances. Adding to the mix, we'll explore the vital role of SIRT1 activation and the myriad factors that contribute to mitochondrial health, reinforcing why this cellular powerhouse is synonymous with our overall well-being.

To cap off our enlightening discussion, we delve into the tangible impacts of diet and supplementation on maintaining youthful vitality. Dr. Kaufman shares her candid experiences—from the acquired tastes of traditional Chinese medicine teas to the powerful effects of fucoidan—and offers sage advice on sourcing quality products without breaking the bank. 

Dr. Kaufmann began her academic career in the field of cellular biology, earning a Master’s Degree from the University of Connecticut in Tropical Ecology and Plant Physiology. Turning to medicine, she received her medical Degree at the University of Maryland, and completed a residency and fellowship at Johns Hopkins in the field of pediatric anesthesiology. For the last five years she has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children’s Hospital. Her avid interest in the science of anti-aging began many years ago as an intense hobby. Utilizing her knowledge in cell biology, human pharmacology and physiology, this hobby has now become a main focus. The project represents years of non-clinical research leading to the first, ever, comprehensive theory of aging.

What we discuss:

(00:02) - Exploring Sirtuins

(10:26) - Bioavailability and Activators for CERT1/3

(21:28) - Discussion on Foods and Supplements

(33:33) - Cellular Homeostasis and NAD

(40:02) - Cellbex and Heat Shock Proteins

(53:44) - Exploring Exosomes and Future Clinic

Thank you to our sponsors for making this episode possible:

Sensate: Go to https://www.getsensate.com and use code NAT

Beam Minerals: Go to https://www.beamminerals.com and use code Nathalie to get 20% off your order

Profound Health:  Visit www.profound-health.com and use code longevity15 to save 15%

Find more from Nathalie:

YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ

Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance

Instagram: https://www.instagram.com/nathalieniddam/

Website: NatNiddam.com

Join Nat’s Membership Community: https://www.natniddam.com/bsp-community

Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08

Find more from Dr. Kaufmann:

Website: https://kaufmannprotocol.com/ 

Instagram: https://www.instagram.com/kaufmannantiaging/ 

There is a huge piece of the puzzle missing for most people when they are working to optimize their health. Most people focus only on external solutions rather than addressing their mental health. Since the brain-gut connection is real – this means optimizing the health of your body needs to include optimizing your mental health. We can’t have one without the other!

That’s why in this episode of Biohacking Superhuman Performance with Raj Jana, we not only explore the interconnectedness of physical health and emotional balance, but we also dive into the concept of emotional lab reports – a tool that could revolutionize the way we understand and manage our emotional health. We also discuss the impact of unaddressed emotional trauma and stress on physical health, what symptoms it commonly manifests as in the body, and so much more.

Raj Jana is the Co-Founder and CEO of Liber8 - a human transformation company that teaches a data driven and heart centered approach to help you experience breakthroughs in your mental & emotional health. Raj is also a former reservoir engineer, 40-Under-40 entrepreneur, and podcast host of the Stay Grounded Podcast. 

Go to Liber8.health and use code NAT10 to save 10% on your Emotional Lab Report.

What we discuss: 

(0:00:03) Introduction to personal work and its impact on mental wellness. Raj's entrepreneurial journey and the importance of addressing underlying issues for true health optimization.

(0:11:08) The connection between physical health and emotional well-being.

(0:18:13) The importance of removing toxic influences, fostering supportive communities, and therapeutic approaches for healing and inner transformation.

(0:25:56) The importance of addressing childhood trauma and emotional well-being for better health outcomes.

(0:36:24) The basic techniques for emotional health.

(0:53:05 Emotional Lab Reports and highlighting the need for emotional education.

(0:57:17) How emotional lab reports can be used to identify emotional patterns, triggers, and recommend resources for personal growth and mental health management.

Thank you to our sponsors: 

BodyBio: Visit BodyBio.com today and get 15% on your first order with code Nathalie

Sensate: Use code NAT at www.getsensate.com/Nat

Leela Q: Use code NAT10 and get 10% OFF on your first Leela Quantum Tech order.

Neurohacker: Visit neurohacker.com/NATHALIE for Qualia Senolytic and use the code NATHALIE to enjoy a 15% discount.

Find more from Raj Jana:

Website: https://liber8.health/

Instagram: https://www.instagram.com/raj_jana/

Find more from Nathalie: 

YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ

Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance

Instagram: https://www.instagram.com/nathalieniddam/

Website: NatNiddam.com

Join Nat’s Membership Community: https://www.natniddam.com/bsp-community

Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08

There are numerous realms within the field of medicine that remain underappreciated, and ozone therapy is one such example. Ozone therapy is an alternative medical treatment that introduces ozone or ozonides to the body.

Today I’m with Micah Lowe and we navigate the science behind this unique approach and the numerous studies and clinical trials that support ozone therapy’s effectiveness despite not having FDA approval and being stigmatized by conventional medicine. We explore its potential as a catalyst for engaging our bodies' intelligence and how it's applied across a diverse range of areas, from dentistry to skincare. Ozone therapy is a fascinating alternative treatment that has the potential to revolutionize the way we view health and well-being. 

Micah Lowe is the founder of Simply O3, which is an ozone equipment company and his mission is to reduce suffering in the world.

Go to https://www.simplyo3.com/ and get 10% off at checkout by using code NATNIDDAM

Thank you to our sponsors for making this episode possible:

Carol Bike: Visit carolbike.com and use promo code NAT for $100 off.

Pendulum: Visit www.pendulumlife.com/nat to shop. No code necessary.

LVLUP: Go to lvluphealth.com and use code NAT10 for 10% off your order.

Find more from Nathalie:

YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ

Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance

Instagram: https://www.instagram.com/nathalieniddam/

Website: NatNiddam.com

Join Nat’s Membership Community: https://www.natniddam.com/bsp-community

Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08

Find more from Micah Lowe:

Instagram: @micahforhealth

Website: https://www.simplyo3.com/

What we discuss:

(0:04:30) - Exploring the Potential of Ozone Therapy

(0:11:00) - Ozone's Impact on Pathogens and Microbiome

(0:15:49) - Ozone's Power in Dentistry and Skincare

(0:22:46) - Understanding Alternative Treatments and Their Effects

(0:30:10) - Antibiotics and Lifestyle's Impact on Health

(0:37:30) - Ozone Therapy and Chronic Oxidative Stress

(0:49:36) - Comparing Oxygen and Ozone Therapy

(0:58:02) - Ozone Therapy for Athletic Improvement

(1:04:38) - IV Ozone Therapy for Fatigue Benefits

(1:08:45) - Ozone Therapy for Skin and Stomach

Could you potentially slow down or reverse your biological "death clock"? In this episode of the Biohacking Superhuman Performance podcast, host and expert Phil Micans delve into the potential of peptides to slow down or even reverse biological aging. With a deep background in Food & Vitamin Technology, Pharmacy, and Biochemistry, Micans shares his extensive experience in the anti-aging field since the 1980s. The discussion encompasses Bioregulator Peptides and their impact on health, Biological Age Control, Melatonin in cancer treatment, advancements in Stem Cell Therapy and Regenerative Medicine, and the role of Growth Hormone Releasing Peptides (GHRPs) in rejuvenation. Real-life success stories illustrate the benefits of peptides in improving bladder, prostate health, and post-cancer treatment.

Phil Micans, a prominent figure in anti-aging medicine, brings a rich expertise to the conversation, drawn from roles like Editor-in-Chief of the Antiaging Magazine, Director of Research and Development at Inner-Age, and Chairman of the International Antiaging Congress. The podcast delves into various health contexts, exploring the holistic role of Bioregulators and discussing the benefits and risks of growth hormone and its forms, including GHRPs and Sermorelin. This episode offers a captivating exploration into the future of health and wellness, highlighting the latest innovations and approaches in the quest for longevity.

To receive a discount on your first order, go to www.profound-health.com/?Aff=Longevity15 and enter the code "Longevity15" at checkout. For savings on Nemorex, use the code "NMRX"

Thank you to our sponsors for making this episode possible:

Pendulum: Visit www.pendulumlife.com/nat to shop. No code necessary.

LMNT: Visit DrinkLMNT.com/NAT - no code needed

Mitopure: Use code NAT10 for 10% off at https://www.timelinenutrition.com/shop/nutrition.

Find more from Nathalie:

YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ

Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance

Instagram: https://www.instagram.com/nathalieniddam/

Website: NatNiddam.com

Join Nat’s Membership Community: https://www.natniddam.com/bsp-community

Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08

Find more from Phil:

Website: https://profound-health-summit.com/  and use code longevity15 to save 15% on your ticket. 

What we discuss:

(00:03) - Bioregulator Peptides and Their Health Impact

(09:17) - The Concept of Biological Age Control

(22:06) - Bioregulators

(32:05) - Melatonin and Immune Bioregulators in Cancer Treatment

(39:46) - Stem Cell Therapy and Regenerative Medicine

(53:30) - GHRPs and Growth Hormone Rejuvenation

(01:03:24) - GHRP2 and Medical Foods

What will 2024 have in store for us?

In this final solo show of the year, I take a reflective look back at the year's significant trends and cast an anticipatory glance towards what's in store for us in 2024. I discuss the intricacies of personal health management, focusing on the critical aspects of hydration, sleep, and exercise. I share my insights on optimizing hydration through advanced filtration systems and the personalized nature of sleep and its profound impact on our goals. I also reflect on the variable responses to supplements and caution against over-reliance on exercise for weight loss. Plus, there's a sneak peek at upcoming discussions on exercise technologies and methods that enhance efficiency and prevent injuries, particularly as we age.

Then, I address the use of GLP-1 agonists, stressing the importance of their responsible use alongside diet and lifestyle changes for weight management. Together, we reflect on the transformative power of home testing and the critical role community plays in mental health and longevity. Lastly, we delve into the cutting-edge technologies that are redefining fitness and health.

Thank you to our sponsors for making this episode possible:

Restoracell: Use code NAT25 at www.vitaliskincare.com

Find more from Nathalie:

YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ

Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance

Instagram: https://www.instagram.com/nathalieniddam/

Website: NatNiddam.com

Join Nat’s Membership Community: https://www.natniddam.com/bsp-community

Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08

What we discuss:

(00:02) - 2023 Trends and Looking Forward

(11:10) - Trends in Hydration, Sleep, and Exercise

(16:33) - Exciting Technologies and Trends of 2024

At this point, most of you know about red light therapy and all the amazing benefits that come with it. That’s why in this episode, we are going to look at it from a different perspective. Rather than focusing solely on the common uses of red light therapy, we’ll dive into its potential in enhancing brain health and cognition function, managing conditions like Parkinson's disease, altering your microbiome, and enhancing the connection between your gut and brain. We’ll also dive into the lesser-known areas of this therapy such as its influence on structured water and so much more. 

We go deep into individual case studies, current trials, and the role of dosing considerations in red light therapy to accentuate the fact that red light therapy is one of the most underrated yet powerful tools and can do some amazing things for healing and optimization – far beyond what most of us realize!

Sarah is the co-founder and CEO of Ceratrhive, a company that develops a very special kind of red light therapy devices that we will also discuss in this episode. She has a postgraduate degree in Clinical Neuroscience from Roehampton University in London. She also holds BSc degrees in Psychological Sciences and Nutritional Medicine from Westminster University and Thames Valley University, respectively. Currently, she is pursuing a diploma in Photobiomodulation at the University of Montpellier in France. During the initial decade of her career, Sarah worked as a research scientist in the pharmaceutical industry. Her role involved planning and conducting experiments to examine the impact of electrostatics on physiology.

Thank you to our sponsors for making this episode possible:

Carol Bike: Visit carolbike.com and use promo code NAT for $100 off.

LeelaQ: Go to www.leelaq.com and use code NATHALIE10 

Profound Health: Visit www.profound-health.com and use code longevity15 to save 15% off your first order.

Find more from Nathalie:

YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ

Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance

Instagram: https://www.instagram.com/nathalieniddam/

Website: NatNiddam.com

Join Nat’s Membership Community: https://www.natniddam.com/bsp-community

Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08

Find more from Sarah:

Website: https://www.cerathrive.com/

Instagram: https://www.instagram.com/cerathrive/ 

Facebook: https://www.facebook.com/CERASystem 

What we discuss:

(00:02) - Red Light Therapy and Its Benefits

(11:58) - Dosing Considerations in Red Light Therapy

(15:33) - Red Light Therapy for the Brain

(24:14) - Structured Water and Its Biological Implications

(33:21) - The Gut-Brain Connection and Light Therapy

(40:47) - Parkinson's Trial and Brain Health Device

(49:15) - Red Light Therapy Case Studies

Key takeaways:

• Nature's red light therapy dosing is complex, with factors like power output, treatment time, and individual differences to consider for optimal results.
• Ongoing research on the effects of red light therapy demonstrates its potential to improve cognition in individuals with Down syndrome and alleviate symptoms of major depressive disorder. Specific devices have been designed for use on the head, as the skull presents a barrier for the light to penetrate.
• When we apply red light to the lower abdomen, it can benefit the microbiome and overall gut health. This is due to the red light therapy targeting the vagus nerve, blood cells, and even fat cells. 

What happens to your gut microbiome during menopause?

In this episode of the Biohacking Superhuman Performance podcast, I chat with Dr. Mindy Pelz about the hormonal shifts that radically alter women's bodies and minds after 40. We discuss the impact of menopause, its potential consequences on weight gain, anxiety, and depression, and why understanding these changes is a cornerstone for wellness. She also explains the role of hormone replacement therapy and the significant lifestyle modifications necessary to accommodate this hormonal decline.

Plus, she shares five crucial lifestyle changes that can make a world of difference during menopause. We tackle everything, from fasting and cycling food intake to repairing the microbiome, detoxing, and the importance of rest. Moreover, we lift the veil on the microbiome and deliver practical steps on enhancing your gut health.

Dr. Mindy Pelz is a renowned holistic health expert and one of the leading voices in educating women about their bodies. She is on a mission to start a women’s health revolution! A native of Los Angeles, Dr. Mindy pursued her early passion for wellness at the University of Kansas where she was a member of the tennis team; and earned her Bachelor of Science in Kinesiology. Dr. Mindy’s high-profile clients include entertainer LeAnn Rimes, former race car driver Danica Patrick, and actress Kat Graham – co-host of their joint podcast “Women United.”  

Thank you to our sponsors for making this episode possible:

Mitopure: Use code NAT10 for 10% off at https://www.timelinenutrition.com/shop/nutrition.

LMNT: Visit DrinkLMNT.com/NAT - no code needed

Berkeley Life: Use code NIDDBL at www.berkeleylife.com

Find more from Nathalie:

YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ

Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance

Instagram: https://www.instagram.com/nathalieniddam/

Website: NatNiddam.com

Join Nat’s Membership Community: https://www.natniddam.com/bsp-community

Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08

Find more from Dr. Mindy:

Website: https://drmindypelz.com/ 

Facebook: https://facebook.com/drmindypelz

Instagram: https://instagram.com/dr.mindypelz

YouTube: https://youtube.com/drmindypelz

What we discuss:

(00:02) - Understanding Hormonal Shifts After 40

(12:54) - Lifestyle Changes for Menopause and Exercise

(18:26) - Exercise's Importance for Overall Health

(25:11) - Microbiome and Fasting for Gut Health

(31:44) - Fasting and Detoxification

(44:03) - Community and Personalized Health Importance

(50:48) - Embracing Change and Sharing Experiences

Key takeaways:

• When women hit their 40s, they must make lifestyle changes as estradiol levels drop. They must consider fasting to fight insulin resistance, resting more, changing their diet, and more. 
• The drop of estradiol in women impacts a variety of neurochemicals, such as dopamine, oxytocin, serotonin, and BDNF, to name a few.

What is eccentric loading?

In this episode of the Biohacking Superhuman Performance podcast, I chat with Raj Chaudhuri about eccentric loading. We delve into the health benefits of eccentric loading, from targeting the crucial type 2B muscle fibers to the time efficiency of this training method. We'll reveal the secrets to maintaining muscle mass for longevity and functional movement, and how this can be achieved with only a few minutes of work per week. 

The conversation will lead us into the world of functional fitness for longevity, the importance of preserving muscle mass as we age, and the limitations of traditional resistance methods. We'll also discuss the exciting possibilities of high intensity training, even for those with busy schedules. 

To conclude, we'll explore the hormonal benefits of eccentric training, particularly the natural production of growth hormones, giving you another compelling reason to incorporate eccentric loading into your fitness regimen. 

Raj Chaudhuri is a Professional Tennis Coach / Strength and Conditioning Coach with over 2 decades of experience working with numerous Grand Slam and WTA Tour Champions as well as US Fed Cup, and Olympic Teams. He is the Inventor of the Synapse. 

Go to www.synapse-ccr.com and use code NAT for free shipping and a 1:1 chat with Raj to get you started (available for the 20 first people only)!

Thank you to our sponsors for making this episode possible:

Neurohacker:  Visit neurohacker.com/NATHALIE and use the code NATHALIE to save 15%.

Berkeley Life: Visit berkeleylife.com and use code NIDDBL.

Profound Health: Visit www.profound-health.com and use code longevity15 to save 15% off your first order.

Find more from Nathalie:

YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ

Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance

Instagram: https://www.instagram.com/nathalieniddam/

Website: NatNiddam.com

Join Nat’s Membership Community: https://www.natniddam.com/bsp-community

Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08

Find more from Raj:

Website: www.synapse-ccr.com/ 

Instagram: www.instagram.com/synapse_ccr

Facebook: www.facebook.com/SynapseCCR 

What we discuss:

(00:02) - Exploring Eccentric Loading in Training

(14:27) - Benefits of Eccentric Loading for Muscles

(20:34) - Eccentric Loading and Neurological Benefits

(27:34) - Neural Stimulation for Longevity Importance

(32:36) - Exploring the Benefits of Synapse Training

(45:40) - Maximizing Intensity and Efficiency in Training

(52:51) - Eccentric Training and Growth Hormone Benefits

Key takeaways:

• Eccentric loading is a method which strengthens both your muscles and your body's connective tissues. This training method minimizes the risk of injury all while maximizing muscle growth.  
• While regular stretching will just increase your range of motion and lengthen the muscle, eccentric training will not only increase your range of motion and lengthen the muscle, but it will also strengthen the tissue so it can create more force at a greater angle 
• Eccentric loading can help preserve the muscle fibers we hang on to as we get older, which is one of the biggest predictors for longevity.

In this solo episode of the Biohacking Superhuman Performance podcast, we share with you my strategies that will help you enjoy the festive celebrations to the fullest, without compromising your health. We dive into the heart of the holiday season, providing practical tips for avoiding post-feasting bloating and maintaining your routines. 

We also chat about the importance of staying hydrated, keeping your blood sugar levels balanced, and how to stay in shape while you enjoy those holiday treats.

As for mental wellness, we equip you with tools and techniques for managing stress and achieving a balanced nervous system amidst the holiday hustle. 

Thank you to our sponsors for making this episode possible:

Restoracell: Use code NAT25 at www.vitaliskincare.com

Find more from Nathalie:

YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ

Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance

Instagram: https://www.instagram.com/nathalieniddam/

Website: NatNiddam.com

Join Nat’s Membership Community: https://www.natniddam.com/bsp-community

Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08

What we discuss:

(00:09) - My Holiday Hacks

(08:58) - Holiday Nutrition and Supplement Tips

(14:30) - Healthy Habits During the Holidays

(25:32) - Tools for Nervous System Balance

If there is one thing that humanity has been striving for since its inception, is the pursuit of longevity. Today I’m with Chris Mirabile, Founder & CEO of NOVOS Labs who brings us one step closer to cracking the code of aging and longevity and offers fascinating insight into the intersection of health, performance, and longevity. We discuss how short-term health strategies may not always contribute positively to longevity, and the nine hallmarks of aging that NOVOS Labs aims to address. These include loss of proteostasis, DNA damage, attrition of telomeres, mitochondrial dysfunction, cellular senescence, altered cellular communication, dysregulated nutrient sensing, epigenetic alterations, and telomere shortening. 

Chris’s interest in health began when he was 12 and evolved into a passion after he was cured of a brain tumor when he was 16. Chris has researched and integrated longevity practices and interventions into his life for more than ten years, has achieved a biological age 13.6 years younger than his chronological age, and according to epigenetic tests like DunedInPACE, is aging 31% slower biologically than chronologically. As we dive deeper into the realm of aging and anti-aging strategies, we bring ourselves one step closer to a future where longevity is not just a dream, but a reality.

Chris Mirabile graduated from NYU Stern School of Business and later won their business plan competition with his startup company, Hotlist, a location-based social network that scaled to 220 million people’s social plans. Chris has launched multiple successful technology ventures and has advised biotech startups and NYU Langone Hospital. 

Vist novoslabs.com and use code NAT5 to save.

Thank you to our sponsors for making this episode possible:

BiOptimizers: Use code bionat10 at magbreakthrough.com/bionat 

LMNT: Visit DrinkLMNT.com/NAT - no code needed

Mitopure: Use code NAT10 for 10% off at https://www.timelinenutrition.com/shop/nutrition.

Find more from Nathalie:

YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ

Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance

Instagram: https://www.instagram.com/nathalieniddam/

Website: NatNiddam.com

Join Nat’s Membership Community: https://www.natniddam.com/bsp-community

Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08

Find more from Chris:

Instagram: instagram.com/slowmyage/

Twitter: twitter.com/slowmyage

Website: slowmyage.com

What we discuss:

(0:03:00) - The Short-Term Health vs. Longevity Dilemma

(0:10:34) - Balancing Strategies for Longevity

(0:19:29) - Aging and Anti-Aging Formulations

(0:28:32) - Autophagy and Microbiome in Aging

(0:39:26) - Understanding Senescent Cells-Safest Approach

(0:53:55) - Comparing Different Aging Clocks

Key takeaways:

• Aging and longevity are complex processes with numerous factors at play, such as loss of proteostasis, DNA damage, attrition of telomeres, mitochondrial dysfunction, cellular senescence, altered cellular communication, dysregulated nutrient sensing, epigenetic alterations, and telomere shortening. 
• Senescent cells, while often perceived negatively due to their contribution to aging, can also play beneficial roles in certain contexts such as wound healing and limiting fibrosis. However, current senolytics can pose risks due to potential toxicity and lack of precision in targeting the right cells.
• While strategies such as severe caloric restriction or prolonged fasting can contribute to longevity, they may also have detrimental effects on short-term health and performance. It's crucial to strike a balance and consider the long-term implications of these health strategies. The ideal time to start implementing longevity strategies, like Novos, is around late 20s to early 30s.