Modern Healthspan

In the talk Dr. Lithgow discusses the current drugs that are available  along with some of the limitations of the studies that we are currently  doing.   

Dr. Gordon Lithgow, is a professor and vice president of Academic Affairs at the Buck Institute. Dr. Lithgow's research focuses on  uncovering genes and small molecules that prolong lifespan through  enhanced molecular stability. Dr. Lithgow has been recognized with a  Glenn Award for Research in Biological Mechanisms of Aging and the  Tenovus Award for Biomedical Research.  *********************************************************************************** 

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In Episode 1 Dr. Lithgow talks about his journey to study aging, his  thoughts on why we age and whether there is limit to the age that humans  can live to.   

Dr. Gordon Lithgow, is a professor and vice president of Academic  Affairs at the Buck Institute. Dr. Lithgow's research focuses on uncovering genes and small molecules that prolong lifespan through  enhanced molecular stability. Dr. Lithgow has been recognized with a  Glenn Award for Research in Biological Mechanisms of Aging and the Tenovus Award for Biomedical Research.

In this video Dr. Sabatini discusses some of the life style interventions that affect our longevity and his personal regimen. This  is the last episode of Dr. Sabatani Interview Series.  

Dr. David Sabatini is an American scientist and Professor of Biology at  the Massachusetts Institute of Technology as well as a member of the  Whitehead Institute for Biomedical Research. He is known for his  important contributions in the areas of cell signaling and cancer  metabolism, most notably the discovery of mTOR, more than 20 years ago.  Since then Dr. Sabatini has continued to work on better understanding  this complex regulator of our metabolism  

Some key references. 

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction 

https://www.biorxiv.org/content/10.1101/2020.10.22.351361v1.full.pdf  

Twenty-five years of mTOR: Uncovering the link from nutrients to growth 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/  

mTOR introduction YouTube Series with Dr. Sabatini 

Dr. David Sabatini is an American scientist and Professor of Biology at  the Massachusetts Institute of Technology as well as a member of the  Whitehead Institute for Biomedical Research. 

He is known for his  important contributions in the areas of cell signaling and cancer  metabolism, most notably the discovery of mTOR, more than 20 years ago.  Since then Dr. Sabatini has continued to work on better understanding  this complex regulator of our metabolism  

In this video Dr. Sabatini discusses how diet effects mTOR activation.  He also talks about calorie restriction and intermittent fasting.  

Some key references. 

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction https://www.biorxiv.org/content/10.1101/2020.10.22.351361v1.full.pdf  

Twenty-five years of mTOR: Uncovering the link from nutrients to growth https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/

In this video Dr. Sabatini discusses rapamycin, how it acts on mTORC1  and mTORC2 and the rapalogs, drugs which are similar to rapamycin but  may be more clinically effective.   

Dr. David Sabatini is an American scientist and Professor of Biology at  the Massachusetts Institute of Technology as well as a member of the  Whitehead Institute for Biomedical Research. He is known for his  important contributions in the areas of cell signaling and cancer  metabolism, most notably the discovery of mTOR, more than 20 years ago.  Since then Dr. Sabatini has continued to work on better understanding  this complex regulator of our metabolism  

Some key references. 

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction https://www.biorxiv.org/content/10.1101/2020.10.22.351361v1.full.pdf  

Twenty-five years of mTOR: Uncovering the link from nutrients to growth https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/  

mTOR introduction YouTube Series with Dr. Sabatini 

https://www.youtube.com/watch?v=EnIerDljc7g

https://www.youtube.com/watch?v=defOfBEuw_M 

https://www.youtube.com/watch?v=tGA9RALG66s

In this video Dr. Sabatini discusses his recent paper and in particular  how the health of the mitochondria impact the activation of mTOR and how  this is signaled. 

Dr. David Sabatini is an American scientist and Professor of Biology at  the Massachusetts Institute of Technology as well as a member of the  Whitehead Institute for Biomedical Research. He is known for his  important contributions in the areas of cell signaling and cancer  metabolism, most notably the discovery of mTOR, more than 20 years ago.  Since then Dr. Sabatini has continued to work on better understanding  this complex regulator of our metabolism  Some key references. 

The paper discussed in the video.  Genome-wide CRISPR screens reveal multitiered mechanisms through which  mTORC1 senses mitochondrial dysfunction 

https://www.biorxiv.org/content/10.1101/2020.10.22.351361v1.full.pdf  

Twenty-five years of mTOR: Uncovering the link from nutrients to growth 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/

Dr. David Sabatini is an American scientist and Professor of Biology at  the Massachusetts Institute of Technology as well as a member of the  Whitehead Institute for Biomedical Research. He is known for his  important contributions in the areas of cell signaling and cancer  metabolism, most notably the discovery of mTOR, more than 20 years ago.  Since then Dr. Sabatini has continued to work on better understanding  this complex regulator of our metabolism In this video Dr. Sabatini discusses how mTOR impacts lifespan and  whether its actions change with age  

Some key references. 

Twenty-five years of mTOR: Uncovering the link from nutrients to growth https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/  

mTOR introduction YouTube Series with Dr. Sabatini https://www.youtube.com/watch?v=EnIerDljc7g https://www.youtube.com/watch?v=defOfBEuw_M https://www.youtube.com/watch?v=tGA9RALG66s

In this video Dr. Sabatini discusses the role of mTOR as the master regulator of the cell and distinguishes between mTORC1 and mTORC2.

Dr. David Sabatini is an American scientist and Professor of Biology at  the Massachusetts Institute of Technology as well as a member of the  Whitehead Institute for Biomedical Research. He is known for his  important contributions in the areas of cell signaling and cancer  metabolism, most notably the discovery of mTOR, more than 20 years ago.  Since then Dr. Sabatini has continued to work on better understanding  this complex regulator of our metabolism  

In this video talks about the biological age measurement in his research  study and also his views on Exercise as an important contributor for  extending healthspan.

We also look at a paper by his team which looks in depth at the effects of acute exercise on the biochemistry of the body. https://www.sciencedirect.com/science/article/abs/pii/S0092867420305080

Dr. Snyder is the Stanford W. Ascherman Professor and Chair, Department  of Genetics and Director, Center for Genomics and Personalized Medicine  at Stanford University. He is a leader in the field of functional  genomics and proteomics. Seminal findings from the Snyder laboratory  include the discovery that much more of the human genome is transcribed  and contains regulatory information than was previously appreciated, and  a high diversity of transcription factor binding occurs both between  and within species. He has also pioneered the use of different  state-of-the-art “omics” technologies as well as wearable devices for  managing human health.  

Dr. Snyder is the Stanford W. Ascherman Professor and Chair, Department  of Genetics and Director, Center for Genomics and Personalized Medicine  at Stanford University. He is a leader in the field of functional  genomics and proteomics. Seminal findings from the Snyder laboratory  include the discovery that much more of the human genome is transcribed  and contains regulatory information than was previously appreciated, and  a high diversity of transcription factor binding occurs both between  and within species. He has also pioneered the use of different  state-of-the-art “omics” technologies as well as wearable devices for  managing human health.   

In this episode, Dr. Snyder will talk about Ageotypes, defined as the part  of the body where the aging process was most active based on a research  study led by him, which could explain why we age at different rates. The study tracked 106 healthy individuals, aged between 29 and 75,  taking blood and biological samples to investigate each person at a deep  molecular level. They carried out tests at least five times over two  years in order to record any changes, with Dr. Snyder even taking part  as a subject of his own research.    Researchers discovered four “ageotypes,” – defined as the part of the  body where the aging process was most active. Those involved in the  trial tended to age most within the immune system, kidney, liver, or at a  metabolic level.  Ageotypes may provide a molecular assessment of personal aging,  reflective of personal lifestyle and medical history, that may  ultimately be useful in monitoring and intervening in the aging process. Personal aging markers and ageotypes revealed by deep longitudinal  profiling