Podcast Notes Playlist: Latest Episodes

Learning Leader Show

Podcast Notes Key Takeaways

• Check Out the Learning Leader Show Episode Page & Show Notes

Read the full notes @ podcastnotes.org

Text Hawk to 66866 to become part of "Mindful Monday." Join 10's of thousands of your fellow learning leaders and receive a carefully curated email from me each Monday morning to help you start your week off right...

Full show notes at www.LearningLeader.com

Twitter/IG: @RyanHawk12   https://twitter.com/RyanHawk12

David Lieberman, Ph.D., is a renowned psychotherapist and the author of eleven books, including the New York Times bestsellers Get Anyone to Do Anything and Never Be Lied to Again. He has trained personnel in the U.S. 

• Ralph Waldo Emerson wrote: “People do not seem to realize that their opinion of the world is also a confession of character.” A person looks at the world as a reflection of themselves. If they see the world as corrupt, they feel on some level that they are corrupt. If they see honest working people, that is frequently how they see themselves.
• “How someone treats you is a reflection of their own emotional health and says everything about them and nothing about you.”
• Speaking negatively behind someone’s back orients you to look for the negative in others. Wouldn’t we rather spend time with people who seek the greatness in others?
• “The less emotionally healthy a person is, the more they denigrate the world to accommodate their own insecurities.”
• Knowledge is not power. Knowledge is a tool. How it is wielded makes all of the difference. Real power is the responsible application of knowledge.
• Word usage: Let’s take the example of giving a compliment. A woman who believes what she’s saying is more likely to use a personal pronoun. For instance, “I really liked your presentation.” However, a person offering insincere flattery might say, “Nice presentation,” or “Looks like you did a lot of research.” In the second case, she has removed herself from the equation.
• The Art of reading the bluff - When a person is bluffing, they are managing others’ impressions to convey the “right” effect and serve a personal agenda. Conversely, the authentic person is not interested in how they come across because they are unconcerned with their image.
  • “People who bluff habitually overcompensate, so you can uncover a bluff instantly by noticing how someone tries to appear.”
• Relationships: Whenever David speaks to couples, he's always on the lookout when the word we is conspicuously absent from the conversation.
• We are attracted to positivity. It reflects humility.
• "Humility connects you to the ownership of mistakes."
  • Humility can recognize a weakness in self.
• The difference between a sociopath and a psychopath:
  • A sociopath has no conscious. They are very dangerous.
  • A psychopath's wiring is off. They were born that way.
• Life and career advice: Find a passion that contributes to the world.
  • Don't get too caught up in image or ego.
• "You can be anything. you're good at. as long as they're hiring." -- Chris Rock

Drive with Dr. Peter Attia

Podcast Notes Key Takeaways

• GLP-1 and GIP both started as drugs to control glucose and insulin resistance in people developing or with type 2 diabetes
• Studies showed the added benefit of GLP-1 agonists on weight loss but the mechanism is unclear, though they do reduce appetite in some way

Read the full notes @ podcastnotes.org

View the Show Notes Page for This Episode

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In this “Ask Me Anything” (AMA) episode, Peter focuses the discussion on two topics getting a lot of attention recently. He first dives deep into GLP-1 agonists, most notably semaglutide and tirzepatide, which originally came to market as diabetes drugs but are now being studied and prescribed for weight loss. He walks through the data and compares the effectiveness of the two drugs, the side effects, and perhaps more importantly, his reservations around wide use of these drugs and who he would consider to be a candidate for them. Next, Peter discusses how metformin, another drug originally brought to market for diabetes management, gained popularity as a potential longevity drug even for non-diabetics. Peter gives his take on this possibility and reviews data from a more recent study investigating the question of whether metformin should be used for general “geroprotection.”

If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #45 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.

We discuss:

• The hype around semaglutide, tirzepatide, and other GLP-1 agonists for weight loss [2:30];
• Overview of GLP-1 agonists and why these drugs are getting so much attention [6:15];
• Defining the term “geroprotective” [13:30];
• Semaglutide: background, brand names, indications, and more [15:15];
• Tirzepatide: background, brand names, indications, and more [19:15];
• How semaglutide and tirzepatide compare in their efficacy in terms of weight loss and other metabolic health metrics [23:45];
• Data showing sustained weight loss and improved metabolic metrics with after more than a year of using semaglutide and tirzepatide [29:00];
• What happens to body weight when a patient discontinues the medication? [34:45];
• Noteworthy side effects of GLP-1 agonists and similar classes of drugs [40:45];
• Increased resting heart rate and other concerning trends in patients using GLP-1 agonists [45:15];
• Changes in body composition (body fat and lean muscle) in patients on GLP-1 agonists [50:45];
• Possible reasons for the loss of lean muscle mass and tips for protecting lean mass [59:00];
• GLP-1 agonists and thyroid cancer [1:01:30];
• Who might be a candidate for GLP-1 agonists? [1:03:45];
• The large financial cost of this class of drugs [1:08:30];
• Metformin as a geroprotective drug: origin of the idea that metformin could be a longevity agent even for non-diabetic patients [1:11:30];
• A 2022 study on metformin sheds more light on the question of whether metformin should be used for “geroprotection” in non-diabetics [1:21:00];
• Peter’s current approach with metformin for his patients [1:25:15]; and
• More.

Connect With Peter on Twitter, Instagram, Facebook and YouTube

With every new technology, some jobs are lost while others are gained. People often focus on the former, but in this episode we chose to highlight the latter – a highly creative role that emerges alongside AI: the prompt engineer.

Until AI can close the loop of its own, each tool still requires a set of prompts. Just like a composer feeds an instrument the notes to play, a prompt engineer feeds an AI a map of what to produce. And if we know anything from music it’s that composing great music takes great skill!

In this episode we explore the emerging importance of prompting with Guy Parsons, the early learnings of how to do it effectively, and where this field might be going.

Will the prompt engineer be more like the highly sought after DevOps engineer, or a proficiency like Excel that you find on every resume? Listen in to hear Guy’s take.

Dan flies to Dharamsala, India to spend two weeks in the orbit of His Holiness the Dalai Lama.

In your journey towards becoming stronger, fitter, and healthier, there often comes a point where you wonder if taking some supplements will help your progress along. But what fitness supplements are actually effective and worth investing in?

Here to answer that question is Layne Norton, a powerlifter and doctor of nutritional science who has a passion for debunking health-related myths and promoting evidence-based recommendations. He’s also, full disclosure, the owner of a supplement company himself. But I don’t have any financial connection to Layne’s company and we keep this conversation neutral and high-level. In our conversation, Layne argues that there are three top-tier research-backed supplements to consider — whey protein, creatine, and caffeine — and we unpack how to use each of them for optimal results. We discuss whether plant proteins are sufficient for building muscle, whether it’s true that creatine causes bloating, acne, and hair loss, how to best time your caffeine intake to energize your workouts, and much more. At the end of our conversation, Layne shares some additional supplements that seem promising for enhancing your health and fitness.

Episode 427: Sam Parr (@TheSamParr) and Shaan Puri (@ShaanVP) speak to Ken Rideout (@KenRideout_), one of the world's best masters runners, successful businessmen and entrepreneur. Ken talks about how he overcame addiction, built a lucrative career, forged mental and physical toughness, and where that's going to take him in the years to come.

Want to see more MFM? Subscribe to the MFM YouTube channel here.

SHAAN'S NEW DAILY NEWSLETTER --> shaanpuri.com

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Links:

* Teddy Atlas Podcast

* Do you love MFM and want to see Sam and Shaan's smiling faces? Subscribe to our Youtube channel.

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Show Notes:

(00:23) - Why Ken is blowing up

(12:25) - His finance background

(23:45) - Ken's Struggles with Addiction

(25:40) - How he got into running/media

(31:25) - Who are the toughest people you have met?

(38:20) - How to deal with adversity

(41:50) - Story of Ken talking smack to Lance Armstrong

(44:30) - How does he make money?

(53:35) - Does this level of activity increase longevity?

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Past guests on My First Million include Rob Dyrdek, Hasan Minhaj, Balaji Srinivasan, Jake Paul, Dr. Andrew Huberman, Gary Vee, Lance Armstrong, Sophia Amoruso, Ariel Helwani, Ramit Sethi, Stanley Druckenmiller, Peter Diamandis, Dharmesh Shah, Brian Halligan, Marc Lore, Jason Calacanis, Andrew Wilkinson, Julian Shapiro, Kat Cole, Codie Sanchez, Nader Al-Naji, Steph Smith, Trung Phan, Nick Huber, Anthony Pompliano, Ben Askren, Ramon Van Meer, Brianne Kimmel, Andrew Gazdecki, Scott Belsky, Moiz Ali, Dan Held, Elaine Zelby, Michael Saylor, Ryan Begelman, Jack Butcher, Reed Duchscher, Tai Lopez, Harley Finkelstein, Alexa von Tobel, Noah Kagan, Nick Bare, Greg Isenberg, James Altucher, Randy Hetrick and more.

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Additional episodes you might enjoy:

• #224 Rob Dyrdek - How Tracking Every Second of His Life Took Rob Drydek from 0 to $405M in Exits

• #209 Gary Vaynerchuk - Why NFTS Are the Future

• #178 Balaji Srinivasan - Balaji on How to Fix the Media, Cloud Cities & Crypto

* #169 - How One Man Started 5, Billion Dollar Companies, Dan Gilbert's Empire, & Talking With Warren Buffett

• ​​​​#218 - Why You Should Take a Think Week Like Bill Gates

• Dave Portnoy vs The World, Extreme Body Monitoring, The Future of Apparel Retail, "How Much is Anthony Pompliano Worth?", and More

• How Mr Beast Got 100M Views in Less Than 4 Days, The $25M Chrome Extension, and More

Twenty Minute VC

Mike Cessario is the Founder and CEO @ Liquid Death, the man hacking the healthy beverage market with the first hilarious water brand. It is working, Liquid Death's latest valuation was over a staggering $700M and Mike has raised over $200M since founding the company from the likes of Science Inc. Away's Jen Rubio, Dollar Shave Club's Michael Dubin, Swedish House Mafia and Tony Hawk to name a few. Prior to founding Liquid Death, Mike was in the advertising industry at a number of dirrect firms including VaynerMedia.

In Today's Episode with Mike Cessario We Discuss:

1.) From Canned Water to $700M Business:

• How did rockstars' hydration problems lead to the founding of Liquid Death?
• How did growing up with guns and heroine needles around him at school, impact how Mike sees the world today? What is he running from? What is he running towards?
• Everyone said, "canned water, that is a stupid idea". What does Mike tell to all entrepreneurs who are told their idea is stupid? How does Mike advise on picking your idea?

2.) How to Build a Truly Great Brand:

• What does the term "brand" mean to Mike?
• What does he mean when he says, "truly great brand transcends functional value"?
• What are the single biggest mistakes Mike sees founders make today on branding?
• Why does Mike believe people will always hate your brand, if it is good?
• What are the biggest brand mistakes Mike has made with Liquid Death?
• What brand does Mike most respect and admire? Why that brand?

3.) Marketing: The Secret to Reaching Millions of People with Little Budget:

• How does the Liquid Death team come up with the ideas they have for content? Why does Mike believe the label "storytelling" is kinda BS?
• Why does Mike believe people will always hate your marketing? What was Mike's biggest lesson from their Superbowl commercial with kids drinking Liquid Death, looking like beer?
• How does Mike decide which channel to prioritise? How has the rise of TikTok and short form video changed their approach to content?
• How does Mike approach resource allocation for new pieces of content? Do they spend big on few bits of content or spend little on many and see what works?

 

In this episode, I discuss our body’s most vital and essential nutrient—water. I explain the structure of water and how it is used by the cells and tissues of our body, how much water we each need to drink and when in order to optimize our mental focus and physical performance; and I include how exercise, humidity, heat, and caffeine affect our hydration needs. I explain how temperature and pH influence water’s physical properties and if there is any scientific basis for drinking so-called “pH water” or “alkalized water” to improve health. I explain how to test your tap water for contaminants (e.g., endocrine disruptors) and the documented problems with fluoride in drinking water. I provide options for filtering drinking water and describe different water types (e.g., reverse osmosis, hydrogen-enriched, electrolyzed reduced, deuterium depleted, etc.). Since the human body is mostly water (55-80% depending on one’s age) and water has essential roles in health, disease and cellular function, everyone ought to benefit from understanding how best to clean our tap water, hydrate effectively and in some cases, adjust the type of water we drink to allow our brain and body to function optimally in regard to health and performance.

For recommended water filters, tests and the full show notes, please visit hubermanlab.com.

Thank you to our sponsors

AG1 (Athletic Greens): https://athleticgreens.com/huberman

LMNT: https://drinklmnt.com/huberman

Thesis: https://takethesis.com/huberman

HVMN: https://hvmn.com/huberman

InsideTracker: https://www.insidetracker.com/huberman

Supplements from Momentous

https://www.livemomentous.com/huberman

Timestamps

(00:00:00) Water

(00:03:33) Tool Deliberate Cold Exposure, Immersion & Showers Mood & Fat Loss

(00:15:26) Sponsors: LMNT, Thesis, HVMN, Momentous

(00:19:27) Water: Physical Properties & Chemistry

(00:26:32) Bonds & Water Phases, “Structured Water”

(00:34:07) Body, Cells & Water

(00:36:22) AG1 (Athletic Greens)

(00:37:37) Water as a Solvent, Temperature & pH

(00:41:49) Water Transport in Cells, Aquaporin Channels

(00:49:46) Alkaline/pH Water; Temperature, pH & Water Transport

(00:55:14) Water Cellular Function, Reactive Oxygen Species (ROS) & Antioxidants

(01:01:20) Sponsor: InsideTracker

(01:02:38) Tool: Baseline Hydration

(01:11:35) Tool: Hydration & Exercise, Galpin Equation

(01:15:40) Tool: Hydration, Sauna, Humidity & Sweat; Thirst, Caffeine

(01:19:15) Hydration; Cognitive & Physical Performance 

(01:23:53) Tool: Water Filtration; Nighttime Urination

(01:29:35) Tap Water Tests, Disinfection Byproducts (DBPs), Fluoride & Thyroid Health

(01:37:18) Tool: Water Filters

(01:44:18) Tool: Resting Tap Water & Sediment

(01:48:13) Tool: “Hard Water”; Magnesium, Calcium & Cardiovascular Health

(01:53:40) Water Temperature

(01:56:42) Water Types: Distilled, Reverse Osmosis, Hydrogen-Enriched

(02:03:26) Hydrogen-Enriched Water, Magnesium, Optimize Hydration

(02:11:13) Tool: Molecular Hydrogen Tablets, Water pH

(02:14:05) Structured Water

(02:16:39) Tool: Water Pipes, Faucet Filter

(02:19:42) Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter

Title Card Photo Credit: Mike Blabac

Disclaimer

In this episode, the gang gets back together! Marc Andreessen and Steven Sinofsky are back to talk about all things AI. We cover the rise of ChatGPT, Bing's AI powered chat Sydney, AI ethics, sentience, whether AI will take over jobs, the economic impact, AI startups vs tech incumbents, and whether it is time for AI to become sentient. This was an incredibly fun episode!

Marc Andreessen is an American entrepreneur, venture capital investor, and software engineer. He is the co-author of Mosaic, the first widely used web browser; co-founder of Netscape; and co-founder and general partner of Silicon Valley venture capital firm Andreessen Horowitz.

Steven Jay Sinofsky is a former president of the Windows Division at Microsoft. He was responsible for the development and marketing of Windows, Internet Explorer, and online services such as Outlook.com and SkyDrive.

In this episode, my guest is Oded Rechavi, Ph.D., professor of neurobiology at Tel Aviv University and expert in how genes are inherited, how experiences shape genes and remarkably, how some memories of experiences can be passed via genes to offspring. We discuss his research challenging long-held tenets of genetic inheritance and the relevance of those findings to understanding key biological and psychological processes including metabolism, stress and trauma. He describes the history of the scientific exploration of the “heritability of acquired traits” and how epigenetics and RNA biology can account for some of the passage of certain experience-based memories. He discusses the importance of model organisms in scientific research and describes his work on how stressors and memories can be passed through small RNA molecules to multiple generations of offspring in ways that meaningfully affect their behavior. Nature vs. nurture is a commonly debated theme; Dr. Rechavi’s work represents a fundamental shift in our understanding of that debate, as well as genetic inheritance, brain function and evolution.

For the full show notes, visit hubermanlab.com.

Thank you to our sponsors

AG1 (Athletic Greens): https://athleticgreens.com/huberman

ROKA: https://roka.com/huberman

HVMN: https://hvmn.com/huberman

Eight Sleep: https://eightsleep.com/huberman

InsideTracker: https://www.insidetracker.com/huberman

Supplements from Momentous

https://www.livemomentous.com/huberman

Timestamps

(00:00:00) Dr. Oded Rechavi

(00:02:08) Sponsors: ROKA, HVMN, Eight Sleep

(00:06:04) DNA, RNA, Protein; Somatic vs. Germ Cells

(00:14:36) Lamarckian Evolution, Inheritance of Acquired Traits

(00:22:54) Paul Kammerer & Toad Morphology

(00:28:52) AG1 (Athletic Greens)

(00:30:06) James McConnell & Memory Transfer

(00:37:31) Weismann Barrier; Epigenetics 

(00:45:13) Epigenetic Reprogramming; Imprinted Genes 

(00:50:43) Nature vs. Nurture; Epigenetics & Offspring

(00:59:06) Generational Epigenetic Inheritance 

(01:09:03) Sponsor: InsideTracker

(01:10:20) Model Organisms, C. elegans

(01:21:50) C. elegans & Inheritance of Acquired Traits, Small RNAs

(01:26:02) RNA Interference, C. elegans & Virus Immunity

(01:34:13) RNA Amplification, Multi-Generational Effects

(01:38:41) Response Duration & Environment

(01:47:50) Generational Memory Transmission, RNA

(01:59:36) Germ Cells & Behavior; Body Cues

(02:04:48) Transmission of Sexual Choice

(02:11:22) Fertility & Human Disease; 3-Parent In Vitro Fertilization (IVF); RNA Testing

(02:17:56) Deliberate Cold Exposure, Learning & Memory

(02:29:26) Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter

Title Card Photo Credit: Mike Blabac

Disclaimer