The Dr. Hyman Show

Hey podcast community, Dr. Mark here. My team and I are so excited to offer you a 7 Day Free trial of the Dr. Hyman+ subscription for Apple Podcast. For 7 days, you get access to all this and more entirely for free!  It's so easy to sign up. Just go click the Try Free button on the Doctor’s Farmacy Podcast page in Apple Podcast. 

In this teaser episode, you’ll hear a preview of our monthly Ask Mark Anything episode.

Want to hear the full episode? Subscribe now. With your 7 day free trial to Apple Podcast, you’ll gain access to audio versions of:

- Ad-Free Doctor’s Farmacy Podcast episodes

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- Monthly Ask Mark Anything Episodes 

- Bonus audio content exclusive to Dr. Hyman+

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This episode is brought to you by Rupa Health, InsideTracker, and Pendulum.

The majority of foods on our market shelves contain insane amounts of added sugar. One of the most problematic of these sugars is fructose, which raises our levels of uric acid, a central player in the metabolic mayhem affecting so many of us. This doesn’t mean all foods containing fructose are bad. Like all parts of health and nutrition, there are nuances we need to consider to create optimal health.

In today’s episode, I talk with Drs. David Perlmutter, Casey Means, and Richard Johnson about how fructose and uric acid impact our physiology, why measuring uric acid levels is so important, and how fructose impacts our energy. 

Dr. David Perlmutter is a board-certified neurologist and five-time New York Times bestselling author. He serves on the board of directors and is a Fellow of the American College of Nutrition. He is the author of Grain Brain among others, and his new book, Drop Acid, was just released. Dr. Perlmutter received his MD from the University of Miami School of Medicine, where he was awarded the Leonard G. Rowntree Research Award.

Dr. Casey Means is a Stanford-trained physician, Chief Medical Officer, and cofounder of metabolic health company Levels, an associate editor of the International Journal of Disease Reversal and Prevention, and a guest lecturer at Stanford University. Her mission is to maximize human potential and reverse the epidemic of preventable chronic disease by empowering individuals with tools that can facilitate a deep understanding of our bodies and inform personalized and sustainable dietary and lifestyle choices.

Dr. Richard Johnson is a professor of medicine at the University of Colorado in Denver and has been a practicing physician and clinical scientist for over 25 years. He is internationally recognized for his seminal work on the role of sugar, and its component fructose, in obesity and diabetes. His work has also suggested a fundamental role for uric acid (which is generated during fructose metabolism) in metabolic syndrome. He previously authored The Sugar Fix with Timothy Gower in 2008, and The Fat Switch in 2012. His new book, Nature Wants Us to Be Fat, was just released.

This episode is brought to you by Rupa Health, InsideTracker, and Pendulum.

Rupa Health is a place where Functional Medicine practitioners can access more than 2,000 specialty lab tests. You can check out a free, live demo with a Q&A or create an account at RupaHealth.com.

Right now InsideTracker is offering my community 20% off at insidetracker.com/drhyman.

To receive 20% off your first purchase of Pendulum’s Akkermansia probiotic supplement, go to Pendulumlife.com and use code MARK20.

Full-length episodes of these interviews can be found here:

Dr. David Perlmutter

Dr. Casey Means

Dr. Richard Johnson

This episode is sponsored by InsideTracker and Athletic Greens.

There are 37 billion chemical reactions happening within your body every second. And every single one of these reactions requires vitamins and minerals to make it work. This is why what you put on your fork is the most important thing you do every day, and it’s why I say food isn’t like medicine—food is medicine. It’s information, and it’s the most powerful drug on the planet. It influences your capacity to live a rich, energetic, connected, soulful life.

In today’s episode of a new series called Health Bites, I discuss how to use food as medicine. I share the principles of eating an optimal diet, a list of the foods we should avoid, my number-one food philosophy, and more!

This episode is sponsored by InsideTracker and Athletic Greens.

InsideTracker is a personalized health and wellness platform like no other. Right now they’re offering my community 20% off at insidetracker.com/drhyman.

AG1 contains 75 high-quality vitamins, minerals, whole-food sourced superfoods, probiotics, and adaptogens to support your entire body. Right now when you purchase AG1 from Athletic Greens, you will receive 10 FREE travel packs with your first purchase by visiting athleticgreens.com/hyman.

Here are more details from the episode (audio version / Apple Subscriber version):

This episode is brought to you by BiOptimizers, InsideTracker, and Pendulum.

I’ve always been a big proponent of learning from those who came before us. The knowledge of ancient cultures is one piece of the foundation of modern medicine, but much shamanic wisdom has been ignored and is now being lost. It benefits us to stop and think about what’s going on below the surface, the things we can’t see—for our health, our perception of reality, everything. Invisible bacteria is one example, wisdom is another. Today I am thrilled to talk to my friend Alberto Villoldo about the role of ancient wisdom in health, healing, and aging optimally. 

Medical anthropologist Alberto Villoldo Ph.D. is an international bestselling author who has researched the shamanic healing practices of the Amazon and Andes for over 25 years. He is the founder of the Four Winds Society, an organization dedicated to the bridging of ancient shamanic traditions with modern medicine and psychology. Dr. Villoldo is the author of numerous books, including Power Up Your Brain; Shaman, Healer, Sage; Mending the Past and Healing the Future with Soul Retrieval; The Four Insights; Courageous Dreaming; One Spirit Medicine, and Grow a New Body. His latest book is The Wisdom Wheel: A Mythic Journey through the Four Directions, which we talk more about in this episode. 

This episode is brought to you by BiOptimizers, InsideTracker, and Pendulum.

BiOptimizers Magnesium Breakthrough formula contains seven different forms of magnesium, all of which have different functions in the body. Go to magbreakthrough.com/hyman and use code hyman10 at checkout for 10% off your next order.

InsideTracker is a personalized health and wellness platform like no other. Right now they’re offering my community 20% off at insidetracker.com/drhyman.

To receive 20% off your first purchase of Pendulum’s Akkermansia probiotic supplement, go to Pendulumlife.com and use code MARK20.

Here are more details from our interview (audio version / Apple Subscriber version):

Learn more about Alberto here and get a copy of his new book, The Wisdom Wheel: A Mythic Journey through the Four Directions, here.

This episode is brought to you by Rupa Health, ButcherBox, and Comvita.

As you lose muscle, you lose mitochondria and your metabolism slows down. Then there is the fact that the natural loss of muscle mass and strength as we age is associated with all-cause mortality and linked to the incidence of many chronic diseases like cardiovascular disease and stroke, hypertension, insulin resistance, and type 2 diabetes. This is why muscle mass is not only essential for maintaining a healthy weight, but it’s also a key factor in reducing the risk of chronic disease and improving your healthspan and longevity. 

In this episode, I speak with Drs. Stuart Phillips and Chris Rinsch, Dr. Gabrielle Lyon, and Mark Sisson about the importance of supporting our body’s largest organ, muscle.

Dr. Chris Rinsch is co-founder and CEO at Amazentis where he oversees the company’s operations in Switzerland. For more than two decades, he has been an innovator in the life sciences arena. 

Dr. Stuart Phillips is a Professor in the Department of Kinesiology and a member of the School of Medicine at McMaster University. He is Tier 1 Canada Research Chair in Skeletal Muscle Health. He is also the Director of the McMaster University Physical Activity Centre of Excellence. 

Dr. Gabrielle Lyon is an integrative physician who completed her fellowship in Nutritional Sciences and Geriatrics at Washington University, St. Louis. She is board-certified in Family Medicine and completed her undergraduate work in Human Nutrition Vitamin and Mineral Metabolism. 

Mark Sisson is the founder of the popular daily health blog, Mark’s Daily Apple, godfather to the Primal food and lifestyle movement, and the New York Times bestselling author of The Keto Reset Diet. His latest book is Keto for Life, where he discusses how he combines the keto diet with a Primal lifestyle for optimal health and longevity. Mark is the author of numerous other books as well, including The Primal Blueprint.

This episode is brought to you by Rupa Health, ButcherBox, and Comvita.

Rupa Health is a place where Functional Medicine practitioners can access more than 2,000 specialty lab tests from over 20 labs like DUTCH, Vibrant America, Genova, and Great Plains. You can check out a free, live demo with a Q&A or create an account at RupaHealth.com.

If you sign up today, ButcherBox will give you two ribeye steaks for free in your first box. Just go to butcherbox.com/farmacy to claim this deal.

Learn more about Comvita at comvita.com, and enter code Hyman25 for 25% off all Manuka honey and bee products. (This offer does not apply to bundles or sale items.)

Full-length episodes of these interviews can be found here:

Dr. Stuart Phillips and Dr. Chris Rinsch

Dr. Gabrielle Lyon

Mark Sisson

This episode is brought to you by Paleovalley and Athletic Greens.

Food should be a tool for helping us feel our best. But most people don’t realize what kind of impact many of the foods they eat are having on their blood sugar—and subsequently their entire body. The symptoms of blood sugar imbalances are everyday occurrences for most people. Feeling hungry even when you just ate, craving sweets, and dealing with acne, hormonal imbalances, and signs of aging, like wrinkles, are just a few of the many symptoms of blood sugar swings. When these continue to go unchecked, more severe dysfunctions can occur, like type 2 diabetes, infertility, fatty liver disease, and dementia. 

In today’s episode, I talk with Dr. Ben Bikman, Dhru Purohit, and Dr. Ronesh Sinha about how common dietary patterns like eating simple carbs throughout the day create constant insulin spikes leading to insulin resistance, which in turn contributes to many diseases and aging.

Dr. Ben Bikman is a renowned metabolic research scientist and a popular speaker on human metabolism and nutrition. Backed by years of research, Dr. Bikman’s mission is to help the world appreciate the prevalence and relevance of insulin resistance. He is the author of the book Why We Get Sick, which offers a thought-provoking yet real solution to insulin resistance and reversing prediabetes, improving brain function, shedding fat, and preventing diabetes.

Dhru Purohit is a podcast host, serial entrepreneur, and investor in the health and wellness industry. His podcast, The Dhru Purohit Podcast, is a top 50 global health podcast with over 30 million unique downloads. His interviews focus on the inner workings of the brain and the body and feature the brightest minds in wellness, medicine, and mindset.

Dr. Ronesh Sinha, author of The South Asian Health Solution, is an internal medicine physician who runs a lifestyle clinic in Silicon Valley focused on reversing insulin resistance in ethnically diverse patients. He is also an expert in corporate wellness and serves as the Chief Medical Officer for the Silicon Valley Employer Forum, where he serves as a global advisor to shape health benefits for over 55 major Silicon Valley companies.

This episode is brought to you by Paleovalley and Athletic Greens.

Paleovalley is offering my listeners 15% off their entire first order. Just go to paleovalley.com/hyman to check out all their clean Paleo products and take advantage of this deal.

AG1 contains 75 high-quality vitamins, minerals, whole-food sourced superfoods, probiotics, and adaptogens to support your entire body. Right now when you purchase AG1 from Athletic Greens, you will receive 10 FREE travel packs with your first purchase by visiting athleticgreens.com/hyman.

Full-length episodes of these interviews can be found here:

Dr. Ben Bikman

Dhru Purohit

Dr. Ronesh Sinha

This episode is brought to you by Rupa Health, Cozy Earth, and InsideTracker.

Many people think of metabolism as one specific system in the body, when in fact it’s the sum of many different processes that are serving other vital roles for us as well. Our bodies are not closed systems, so our environment, social networks, diet, hormones, microbiome, genetics, and more, all influence how well our metabolism works, or how well we can extract energy from our food. I’m so happy to sit down with my good friend Dr. William Li to talk about what metabolism really means, why the old way of thinking about metabolism hasn’t helped us, and how to make positive impacts on our metabolism at any age.

Dr. William Li is a world-renowned physician, scientist, speaker, and author of Eat to Beat Disease - The New Science of How Your Body Can Heal Itself. He is best known for leading the Angiogenesis Foundation. His groundbreaking work has impacted more than 70 diseases, including cancer, diabetes, blindness, heart disease, and obesity. An author of over 100 scientific publications in leading journals such as Science, the New England Journal of Medicine, The Lancet, and more, Dr. Li has served on the faculties of Harvard, Tufts, and Dartmouth Medical School.

This episode is brought to you by Rupa Health, Cozy Earth, and InsideTracker.

You can check out a free, live demo with a Q&A or create an account at RupaHealth.com.

Right now, get 40% off your Cozy Earth sheets at cozyearth.com and use code MARK40.

InsideTracker is offering my community 20% off at insidetracker.com/drhyman.

Here are more details from our interview (audio version / Apple Subscriber version):

Mentioned in this episode

Perspective: Obesity—an unexplained epidemic

Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models

Daily energy expenditure through the human life course

Get a copy of Dr. Li’s book, Eat to Beat Disease: The New Science of How Your Body Can Heal Itself, here and check out his Masterclass with Dr. William Li here.

This episode is brought to you by Rupa Health, Thrive Market, and Comvita.

Today, as part of my Masterclass series, I’m answering personal questions my team put together from the “Let’s Get Closer” card deck. I am joined by my good friend and podcast host, Dhru Purohit, to give you a peek into my personal life as I answer questions about my greatest struggles, what I’m addicted to, the best advice I’ve received, and much more. 

Dhru Purohit is a podcast host, serial entrepreneur, and investor in the health and wellness industry. His podcast, The Dhru Purohit Podcast, is a top 50 global health podcast with over 30 million unique downloads. His interviews focus on the inner workings of the brain and the body and feature the brightest minds in wellness, medicine, and mindset.

This episode is brought to you by Rupa Health, Thrive Market, and Comvita.

Rupa Health is a place where Functional Medicine practitioners can access more than 2,000 specialty lab tests from over 20 labs. You can check out a free, live demo with a Q&A or create an account at RupaHealth.com.

Thrive Market is an online membership-based grocery store that makes eating well convenient and more affordable. Join today at thrivemarket.com/hyman to receive an extra $80 worth of free groceries with your first order.

Comvita offers the most premium, pure, well-researched, and sustainably sourced Manuka products available on the market today. You can learn more at comvita.com, and enter code Hyman25 for 25% off all Manuka honey and bee products. (This offer does not apply to bundles or sale items.)

In this episode, we discuss (audio version / Apple Subscriber version):

Mentioned in this episode:

Let’s Get Closer by Intelligent Change

Inner.U

How to Conquer Your Mind to Live Your Best Life with Colin O’Brady

The Spontaneous Fulfillment of Desire by Deepak Chopra

This episode is brought to you by ButcherBox and Athletic Greens.

Our gut is a powerful control center, due to its bidirectional communication with the brain, which we call the gut-brain axis. This links the emotional and cognitive centers of the brain with intestinal function. Certain conditions, such as irritable bowel syndrome (IBS), are tied to imbalances in the gut-brain axis and can benefit from taking a systems approach in healing, which includes looking at diet, the microbiome, stress management, and more.

In today’s episode, I talk with Dr. Todd LePine, Dr. Emeran Mayer, and Dr. George Papanicolaou about various root causes of irritable bowel syndrome, including microbiome imbalance, parasites, and stress.

Dr. Todd LePine graduated from Dartmouth Medical School and is board certified in Internal Medicine, specializing in Integrative Functional Medicine. He is an Institute for Functional Medicine certified practitioner. Prior to joining The UltraWellness Center, he worked as a physician at Canyon Ranch in Lenox, MA, for 10 years. Dr. LePine’s focus at The UltraWellness Center is to help his patients achieve optimal health and vitality by restoring the natural balance to both the mind and the body. His areas of interest include optimal aging, bio-detoxification, functional gastrointestinal health, systemic inflammation, autoimmune disorders, and the neurobiology of mood and cognitive disorders.

Dr. Emeran Mayer is the author of The Gut-Immune Connection as well as The Mind-Gut Connection. He has studied brain-body interactions for the last 40 years, is the executive director of the G. Oppenheimer Center for Neurobiology of Stress and Resilience, and is the founding director of the UCLA Brain Gut Microbiome Center at the University of California at Los Angeles. His research has been supported by the National Institutes of Health for the past 25 years, and he is considered a pioneer and world leader in the area of brain-gut microbiome interactions and its clinical implications.⁣

Dr. George Papanicolaou is a graduate of the Philadelphia College of Osteopathic Medicine and is board certified in Family Medicine from Abington Memorial Hospital. He is also an Institute for Functional Medicine practitioner. He worked on the Navajo reservation for four years at the Chinle Comprehensive Medical Facility, where he served as the Outpatient Department Coordinator. In 2000, he founded Cornerstone Family Practice in Rowley, MA. In 2015, he established Cornerstone Personal Health, a practice dedicated entirely to Functional Medicine. Dr. Papanicolaou joined The UltraWellness Center in 2017.

This episode is brought to you by ButcherBox and Athletic Greens.

If you sign up today, ButcherBox will give you two ribeye steaks for free in your first box. Just go to butcherbox.com/farmacy to claim this deal.

Right now, when you purchase AG1 from Athletic Greens, you will receive 10 FREE travel packs with your first purchase by visiting athleticgreens.com/hyman.

Full-length episodes of these interviews can be found here:

Dr. Todd LePine

Dr. Emeran Mayer

Dr. George Papanicolaou

This episode is brought to you by Mitopure, InsideTracker, and Rupa Health.

The topic of veganism is hotly debated in terms of health and environmental stewardship. But how did the idea that being vegan is the best way to eat for our bodies and the planet develop in the first place? The answer is more complex than you might think. On this episode of The Doctor’s Farmacy, Jayne Buxton challenges the notion that veganism is the cure for disease and climate change and explains how we got here. 

A British-Canadian, Jayne Buxton is an author of both fiction and non-fiction. She spent fifteen years doing research-intensive work as a management consultant for a major firm before writing her 1998 book, Ending the Mother War: Starting the Workplace Revolution, which explored the entrenched positions and false choices faced by women wanting to combine motherhood with careers. Jayne subsequently spent years working in the field of work-life balance, advising both parents and corporations, before turning to writing full time. Her new book, The Great Plant-Based Con, challenges the dominant narrative about the vegan diet and proposes a compelling new perspective.

This episode is brought to you by Mitopure, InsideTracker, and Rupa Health.

Get 10% off Mitopure at timelinenutrition.com/drhyman and use code DRHYMAN10 at checkout.

Right now InsideTracker is offering my community 20% off at insidetracker.com/drhyman.

Rupa Health is a place where Functional Medicine practitioners can access more than 2,000 specialty lab tests. You can check out a free, live demo with a Q&A or create an account at RupaHealth.com.

Here are more details from our interview (audio version / Apple Subscriber version):

Learn more about Jayne Buxton and her work at thegreatplantbasedcon.com and get her book, The Great Plant-Based Con: Why eating a plants-only diet won't improve your health or save the planet, here.