In this special Asprey Archive episode you’ll learn that while yes, testosterone fuels energy and performance, it’s not the be-all and end-all solution for men’s health woes. A systems biology approach considers many other aspects and provides a broader perspective about what’s going on with you.

This conversation features board-certified urologist Tracy Gapin, M.D. He joined us in 2022 for this episode to discuss new ways for men to improve their health and performance. He uses epigenetic coaching, hormones, peptide therapy, biometric monitoring, and unique nutrition and lifestyle interventions.

In his book, “Male 2.0™: Cracking the Code to Limitless Health and Vitality,” he says medical school, residency training and even a two-decade career in urology and surgery specialties didn’t teach him how to get to root causes of men’s issues and solve them. He had a health crash of his own at 42. Since neither he nor his doctor had good answers, he went on a quest of discovery and change. 

He founded the Gapin Institute for High Performance Medicine and created the proprietary N1 Performance Health Program to go beyond conventional options.

This conversation goes even further into what creates epigenetic signals that affect the function and expression of your genes. You’ll learn, too, that your mindset, stress and environment—and how you do or don’t control those things—have everything to do with your energy and focus. If you’re aiming for higher performance, Dr. Tracy suggests a trifecta that makes sleep a priority, builds resilience to stress, and creates consistent behaviors with intention.

Sponsors:

• EnVy | Go to https://www.envypillow.com/ and use code DAVE10 at checkout for an exclusive discount.

Resources:

Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books 

Website: Gapin Institute for High Performance Medicine

Instagram: @DrTracyGapin

Instagram: @Dave.Asprey

YouTube: @DaveAspreyBPR

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In today’s episode you’ll explore the complexities of memory with Dr. Charan Ranganath, a top expert in cognitive neuroscience. This episode takes you through the fascinating ways our brains record, process, and utilize memories to navigate daily life and shape our futures. You’ll learn how memory impacts decision-making, the truth about common myths, and the role of groundbreaking research in our understanding of cognitive function. Dr. Ranganath shares insights from his book "Why We Remember," shedding light on the brain's ability to predict and prepare for what comes next. Whether you're a seasoned biohacker or just starting, this conversation offers valuable perspectives on the science of memory that will change how you think about your mind.

Timestamp highlights 

• (00:01:03) The Role of Memory in Shaping Our Reality 
• (00:04:51) The Truth about Remembering and Forgetting 
• (00:12:27) Psychedelics, Plasticity, and the Future of Memory Research 
• (00:16:32) The Ethics of Memory Enhancement 
• (00:21:10) Harnessing Memory for Predicting the Future 
• (00:29:17) How Memory Evolves with Age 
• (00:33:27) The Power of Pattern Recognition in Human Intelligence 
• (00:38:34) Debunking Memory Myths with Dr. Ranganath 
• (00:40:54) The Role of Diet and Lifestyle in Memory Preservation 
• (00:50:18) What 'Spider Sense' Says About Our Predictive Brains 
• (00:55:10) Building a Life of Meaningful Memories 
• (00:59:42) How Long Would You Want to Live if Your Memory Stayed Intact? 

Sponsors 

• Sunlighten | Head to Sunlighten.com/dave to save up to $600 
• STEMREGEN | Go to STEMREGEN.co/Dave for 20% off 

Resources 

• Get your copy of 'Why We Remember' by Dr. Charan Ranganath 
• Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books 
• Follow Dr. Ranganath on Instagram: @TheMemoryDoc 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Join Dave Asprey for a fascinating discussion with Colleen Cutcliffe, Ph.D., on leveraging the power of GLP-1 for natural weight management and overall well-being. Discover how probiotics can naturally stimulate GLP-1 production in the body, helping reduce food cravings and maintain a healthy gut lining. We delve into the differences between pharmaceuticals and natural probiotics, the importance of GLP-1 for longevity, and practical tips for optimizing your microbiome health. Whether you're battling cravings or seeking to prevent diabetes and its associated risks, this episode sheds light on natural, effective strategies for a healthier life. 

Timestamp Highlights: 

(00:00:01) Introduction to GLP-1 and weight management 

(00:01:06) Colleen Cutcliffe, PhD, on natural ways to stimulate GLP-1 

(00:04:41) The role of microbiome in regulating GLP-1 and cravings 

(00:16:00) The GLP-1 probiotic: benefits beyond weight loss 

(00:34:13) Dietary interventions to support GLP-1 probiotics 

(00:42:23) Personal experiences and results with GLP-1 probiotics 

(00:51:01) The different pendulum products and who should take them 

(00:59:23) How GLP-1 probiotics impact the gut lining and overall health 

(01:03:56) GLP-1 and its connection to longevity and disease prevention 

Sponsors: 

Pendulum | Get 20% off membership at https://pendulumlife.com with code Asprey20 

ARMRA | Go to https://www.TryARMRA.com and use code Dave for 15% off 

ARRC LED | For More Information Visit ARRCLED.com 

Resources: 

Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books  

Instagram: @Dave.Asprey 

Pendulum GLP-1 Probiotics: https://pendulumlife.com (Code: Asprey20 for 20% off) 

Instagram: @pendulumlifeco

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today you'll step inside the real world of fame with Ramon Hervey II, the mastermind manager behind iconic figures like Vanessa Williams, Bette Midler, and Richard Pryor. He is author of "The Fame Game: An Insider's Playbook for Earning Your 15 Minutes." With years of experience guiding celebrity journeys, Ramon dismantles the myths surrounding fame and success. In this episode, he shares invaluable insights on why pouring your heart into your work and letting excellence lead is more fulfilling and enduring than the pursuit of fame. Ramon, a Master of Media and public perception, brings a wealth of knowledge from his time shaping the narratives of household names. Get ready to redefine your ambitions and align your pursuits with the values that truly matter. You’ll step beyond the veneer of fame into a world where your achievements stand the test of time. 

(00:00:06) Introduction to the complexities of fame 

(00:01:06) Ramon's correction and insights into the unpredictability of fame 

(00:04:04) The statistical rarity of becoming famous 

(00:06:03) The truth behind fabricating fame in the entertainment industry 

(00:09:18) The importance of authenticity and integrity 

(00:21:54) Ramon's experience with the toxic side of fame 

(00:29:32) The gratitude for positive fan interactions 

(00:32:13) Ramon's advice for influencers on handling fame 

(00:41:19) How industries can shift and impact your fame 

(00:42:27) Dave's creation of the biohacking movement 

(00:48:41) The strategic management of public image and fame 

(00:52:10) The dangers of seeking fame for fame's sake 

(00:58:55) The misuse of fame and its consequences 

(01:07:13) The role of media and public perception 

(01:14:04) Ramon's take on fame as currency and liability 

(01:20:22) The Tenets of Fame - managing fame without destruction 

Sponsors: 

• Timeline Nutrition | Go to https://www.timeline.com/dave and get 10% off your first order 
• 40 Years of Zen | Go to https://www.40YearsOfZen.com/Dave for an exclusive offer.

Resources: 

• Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books 
• Website: www.herveyandcompany.com 
• IG - @trichemon 
• FB - Ramon Hervey II 
• Twitter: @coolramon 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today you’ll learn about female hormones: what they are, what they do, and what disrupts them. You’ll learn about the hormonal shifts that happen at different ages and life stages and get tips on how to balance hormones and make them work for you, not against you.

This conversation features Anna Cabeca, D.O.. Dr. Anna is a Doctor of Osteopathy who’s triple-board certified in gynecology and obstetrics, integrative medicine, and anti-aging and regenerative medicine. She has additional certifications in functional medicine, sexual health, and bioidentical hormone replacement therapy. 

She joins this special preview episode to talk about female hormones. It’s her particular area of expertise and one of The Human Upgrade’s all-time Top 10 podcast topics. Today’s hormone discussion includes:

• How hormone disruptors go beyond stress to mold, and product and environmental toxins
• How estrogen levels change over time
• What’s going on with progesterone, pregnenolone and DHEA, too
• What happens to hormones during perimenopause and menopause
• What’s causing brain fog
• What to know about bioidentical hormones
• How detoxing affects hormones
• How to keep your vaginal microbiome balanced
• How “food as medicine” helps balance hormones
• How hormones influence longevity
• And much more!

For the past 20 years, Dr. Anna's educated and helped women with their hormones through her private practice, books, online videos and articles. Learn more about her work with women’s hormone health:

• “MenuPause: Five Unique Eating Plans to Break Through Your Weight Loss Plateau and Improve Mood, Sleep, and Hot Flashes”
• “The Hormone Fix: Burn Fat Naturally, Boost Energy, and Stop Hot Flashes the Keto-Green™️ Way”
• “Keto-Green™️ 16”

Sponsors:

• Quantum Upgrade | Go to https://quantumupgrade.io/dave for a 7-day Free Trail
• Neurohacker Senolytic | https://Neurohacker.com/Dave to get 15% off.

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if you could catch cancer in its earliest stages, when it's most treatable—would you seize that chance? Our guest today is Dr. Josh Ofman, the president of GRAIL, and he's pioneering early cancer detection in a revolutionary new way. You'll discover the cutting-edge advances in multi-cancer early detection that are transforming the fight against this swift and silent killer. You'll also learn about the full potential of the GRAIL gallery test in your proactive health management. This technology is ushering in a new era in cancer care but also signals a paradigm shift in disease prevention. Learn why yearly screenings are your best strategy in the race against cancer. Prepare to dive deep into how the latest biotech innovations could significantly extend your life span!

Timestamp Highlights 

(00:01:03) An Unsettling Trend in Cancer Proliferation  

(00:04:51) Introducing Dr. Josh Ofman and the GRAIL Test  

(00:12:27) The Revolutionary Approach of Multi-Cancer Early Detection  

(00:16:32) The Shift to Biological Signals in Cancer Detection  

(00:21:10) The Empowering Aspect of Knowing Your Cancer Status  

(00:29:17) How GRAIL's Gallery Test Can Change the Paradigm of Cancer Treatment  

(00:33:27) The Critical Nature of Annual Cancer Screening  

(00:38:34) How Early Detection Affects Treatment Options and Survival  

(00:40:54) The Future of GRAIL in Other Disease Pathways  

(00:50:18) Combating Fear and Misconceptions Around Cancer  

(00:55:10) The Impact of Socioeconomic Factors on Cancer Incidence  

(00:59:42) The Pivotal Role of Data in Personalized Health 

Sponsors  

• ARRC LED | The perfect device for daily home use. For more information visit arrcled.com. 
• Leela Quantum | Visit www.LeelaQ.com/Dave for 10% Off 

Resources  

• Dave Asprey’s NEW Book ‘Smarter Not Harder’: daveasprey.com/books  
• GRAIL Multi-Cancer Early Detection Test: Visit www.Galleri.com/Dave to see if you’re eligible for a $50 off limited-time online-only offer. 
• GRAIL Research and Studies: grail.com/clinical-studies GRAIL on  
• Twitter: @GRAILbio 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

I had the pleasure of talking with Dr. Christina Rahm, who has an inspiring journey from a pharmaceutical executive to an advocate for integrating holistic health solutions with rigorous scientific methods. We dive into the impact of spirituality on wellness, the transformative power of neural feedback, and the intersection of technology and ethics in health. Dr. Rahm shares her insights into combating health issues with nanotechnology and discusses the influence of the environment on our well-being.

(00:00:01) Introducing Dr. Christina Rahm and her diverse expertise in health and science 

(00:02:17) The transparency and ethics in the pharmaceutical industry 

(00:07:07) Transition to holistic health solutions and bioengineering innovations 

(00:14:10) Addressing the pervasive health effects of fungus and mold 

(00:27:11) Biotechnology's role in creating a brighter future for human health 

(00:38:04) Discussing the unexpected benefits of childhood diseases on immune function 

(00:50:31) Exploring annual detox rituals and their scientific basis 

(01:03:01) Handling criticism with humor: The "Your Mom" strategy

(01:06:57) Announcement of Upgrade Labs locations and offerings  

Sponsors: 

Mitosynergy | Exclusive offer for listeners – 15% off by going to www.Mitosynergy.com/Dave 

ARMRA | Go to www.TryARMRA.com and use code Dave to get 15% off your First Order 

Resources: 

Dr. Christina Rahm's website: https://drchristinarahm.com/ 

Root Brands: https://therootbrands.com/ 

Upgrade Labs: https://upgradelabs.com/ 

Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books  

Dr. Chrsitina Rahm’s Instagram Page: https://www.instagram.com/drchristinarahm/ 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this profound episode, Maria Menounos shares her journey through significant health challenges, including a brain tumor and diabetes, and how she emerged more resilient and health focused. Renowned for her vibrant career in entertainment and now as a wellness advocate, Maria delves into the transformative power of facing mortality, redefining medicine, and leveraging biohacking to enhance her life. She gives actionable advice for those looking to preserve their health while pursuing their dreams and the importance of aligning career success with personal well-being. 

(00:00:01) - Maria's resilience through her health battles 

(00:03:29) - How health challenges can redefine life's purpose 

(00:14:18) - Yoga Nidra and the shift from anxiety to empowerment 

(00:23:25) - The importance of biohacking in Maria's recovery 

(00:34:16) - Sunlight and its underrated health benefits 

(00:47:30) - The rise of biohacking technologies and their accessibility 

Sponsors 

BiOptimizers | Go to www.bioptimizers.com/Dave for 10% off 

Timeline | Go to www.TimelineNutrition.com/Dave to get 10% off your first order 

Resources 

Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books  

Heal Squad: https://www.healsquad.com/ 

Maria Menounos Instagram: @mariamenounos 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today, Calley Means joins the show to march onward on his war path to changing the incentives of modern health. He’s a champion of food and lifestyle practices as medicine—and, in May of this year, he’s putting out a new book on the subject which we outline today, called Good Energy.

His sister, Dr. Casey Means, is the co-author of Good Energy. You know her from a past appearance on this show and as the founder of Levels so this mission really is a family affair in the best way possible.

Going from a food lobbyist to the other side of the fence, Calley is a deeply serious and dedicated champion for the people. But he brings much more to the table today than a polished delivery and a new book; he is also the co-founder of True Medicine, which works to connect tax-advantaged spending to healthy food and exercise. 

It’s helped hundreds of thousands of people access affordable care by leveraging the convoluted systems currently in place to block them from doing so—no easy task.

In this conversation, Calley lays the foundation for our food culture as it stands today—bleak, corrupt, poisoned, sick, and getting sicker. We deconstruct the layers of federal agencies and historical precedent that have brought us to this point, and we’re direct in our suggestions (demands) on how to fix it.

And all the facts are laid bare. Dots are connected in broad daylight, on network television, and within the algorithms that power our social feeds. Our kids are at stake, and the only option is to take affirmative action on what we know is right. 

(00:01:19) Calley’s Inspirations & Metabolic Mission

(00:11:16) Redefining the Meaning of Medicine 

(00:19:21) Is America a Viable Place To Raise Healthy Kids?

(00:30:41) Meaningfully Changing Healthcare Incentives

(00:42:56) Now What—How Does Society Make Positive Change?

(00:49:34) The Media’s Role in Society’s False Narratives

(00:56:49) Undoing the Damage of the Food Pyramid

Sponsors

ARRC LED | The perfect device for daily home use. For more information visit arrcled.com.

Resources

Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books 

Good Energy: The Surprising Connection Between Metabolism and Limitless Health

Truemed: truemed.com

The Human Upgrade is produced by Crate Media.

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

How can we make our furry best friends live longer, healthier lives?

A true pioneer in this field, Dr. Matt Kaeberlein, is here to unpack this important subject while highlighting the crossover between human and canine longevity. You read that right; this episode isn't just for dog lovers—it's a deep dive into longevity for humans, too. 

Dr. Matt Kaeberlein, who's the CEO of Optispan and a key figure in the Dog Aging Project, brings a wealth of knowledge from his distinguished career in aging and healthspan research. He's an Affiliate Professor at the University of Washington and a notable figure in gerontology, recognized by organizations like the American Association for the Advancement of Science and the Gerontological Society of America. 

Matt's work is groundbreaking, demonstrated in over 250 scientific papers on aging, numerous prestigious awards, and he's even a Fellow of several aging associations. He's on a mission to unlock the secrets of aging, not just in humans, but in our four-legged companions as well.

We explore the accuracy of measuring age with telomeres versus epigenetics and get into the nitty-gritty of diet's impact on longevity for both dogs and humans, reminding us it's not just about living longer, but living well.

Matt explains the impressive trial results on rapamycin for reducing age-related inflammation, a breakthrough that's not just exciting for us but also for our pets. Finally, we touch on how AI is revolutionizing our approach to understanding and extending our healthspan.

For those who want to get more involved, check out dogagingproject.org. It's not every day you meet someone who's made such significant strides in understanding aging across species. So whether you're a pet parent or just passionate about extending your own health span, this episode is for you.

(00:01:31) Dogs Are the Bridge Between Lab Studies & Human Longevity

(00:11:09) Exploring the Impact of Diet on Longevity

(00:18:50) How Our Unique Biology Impacts Aging

(00:26:33) Exploring How Size & Diet Impact Health Across Species

(00:37:55) Fighting Age-Related Inflammation with Rapamycin

(00:56:40) AI Interventions for Longevity Testing

Sponsors

ARMRA | Try it out for yourself at TryARMRA.com. Use code “Dave” to get 15% off your first order

STEMREGEN | Go to STEMREGEN.co/Dave for 20% off.

Resources

Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books 

Learn More: dogagingproject.org

Website: optispan.life

X: @mkaeberlein

Listen: The Optispan Podcast with Matt Kaeberlein

The Human Upgrade is produced by Crate Media.

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.