If you're looking to improve your circulation / blood flow and athletic performance or simply combat increased vascular permeability (which can create edema and, therefore, hypoxia) due to the damaging effects of hyperglycemia, inflammation, toxins, etc..., then this episode is a MUST-listen! We're delving into the intricacies of the vesugen bioregulator peptide – so stay tuned for some pretty intriguing research!

Topics:

1. Introduction to the Episode

- Previous background interest in vesugen: Lyme and Mold / CIRS issues

- Introduction to bioregulator peptide vesugen

- Effects on blood vessels, circulation, hypoxia, and athletic performance

2. Quick Overview of CIRS and the Circulatory System

- Damage to the endothelial blood vessel wall due to high MMP-9 levels

- Hemolysins released by MARCoNS

- Narrowed capillaries and induced hypoxia

- Interest in vesugen

3. Blood Cell Formation

- Hematopoiesis

- Process and origin in the bone marrow

- Characteristics of multipotent hematopoietic stem cells (HSCs)

- Regulation of HSC self-renewal vs. differentiation

- Myeloid and Lymphoid Progenitors

- Differentiated blood cells from each progenitor type

- Pathway: Myeloid progenitor to erythrocyte

- Role of Erythropoietin (EPO)

4. Maturation Process of Erythrocytes

- Ejection of nucleus and organelles

- Hemoglobin acquisition

- Biconcave shape for optimal gas exchange

- Transition to the bloodstream via sinusoids

5. Vascular Wall Anatomy and Dysfunction

- Overview of vascular wall layers: Tunica intima, tunica media, and tunica externa

- Detailed understanding of endothelial cell functions

- Barrier function and vascular permeability

- Vascular tone and blood flow regulation

- Inflammation and the role in immune response

- Angiogenesis and its significance

6. Bioregulator Peptide Vesugen

- Definition and unique characteristics

- Composition: Lysine, Glutamine, and Asparagine

- Mechanism of action: Promotion of endothelial cell proliferation

7. Benefits and Potential of Vesugen

- Restoration of endothelial function

- Role in injury and endothelial dysfunction scenarios: edema, hypoxia, etc...

- Protective effect on the blood-brain barrier

- Impact on nitric oxide production and athletic performance, hair growth, skin health

Thanks so much for tuning in!

Pre-Order Chloe's Book "⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠" and email [email protected] a screenshot of the order confirmation to enter the GIVEAWAY!

If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening!

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Today, we are talking about how neurons communicate with each other via neurotransmitters and how these neurotransmitters contribute to various brainwave states. Then, we dive into different auditory stimuli that can entrain the brain to certain brainwave states, thus permitting the supposed ongoing release of certain neurotransmitters. This may ultimately affect mood, productivity, relaxation, and more! Stay tuned... this is a good one!

Topics:

1. Introduction:

- The potential of sound to optimize brain chemistry

- Different types of auditory stimuli: music, sound frequencies, natural soundscapes, and binaural beats

2. Understanding the Brain:

- Anatomy of the Central Nervous System: Neurons and Glia cells

- Structure of Neurons: Cell body, axon, and dendrite

- Neurotransmitters and synapses

3. Neural Communication Process:

- Resting Membrane Potential and its maintenance

- Stimulation of Neurons

- Action Potential:

- Depolarization and Repolarization

- Role of Sodium and Potassium ions

- Propagation of Action Potential and its role in neurotransmitter release

4. Brainwaves & Neurotransmitters:

- Introduction to Brainwaves

- Role of Amino Acid Neurotransmitters: GABA (inhibitory) and Glutamate (excitatory)

- Different Brainwave Types: Delta, Theta, Alpha, Beta, and Gamma waves

5. External Influences on Brainwaves:

- Auditory stimuli

- The concept of brainwave entrainment

6. Application & Implications:

- Using brainwave entrainment to optimize various tasks:

1. Morning Meditation or Relaxation

2. Work, Problem Solving, and Analytical Thinking

3. Creative Work or Brainstorming

4. Deep Work or High-Level Information Processing

5. Breaks, Quick Naps, or Short Meditations

6. Evening Relaxation or Preparing for Sleep

7. Deep Meditation or Deep Sleep

7. Scientific Findings on Music & Brainwaves:

- Mozart’s Sonata in D Major for Two Pianos K448

- Beethoven’s "Für Elise"

- The monochord sounds and its effects

- "Pleasant" music's influence on patients with depression, schizophrenia, or anxiety

8. Binaural Beats:

- Introduction and concept

- How you can use binaural beats

9. Conclusion:

- Importance of balanced brainwave activity

- The interrelationship between neurotransmitters and brainwaves

Thanks so much for tuning in!

Pre-Order Chloe's Book "⁠75 Gut-Healing Strategies & Biohacks⁠" and email [email protected] a screenshot of the order confirmation to enter the GIVEAWAY!

If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening!

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Today, we are honored to welcome Dr. Zulia Frost to the podcast! Zulia, a prominent clinician globally recognized, specializes in neuromodulation, bio-resonance, and photobiomodulation therapies. Holding a Doctorate in General Medicine and Pediatrics, along with advanced training in ultrasonic diagnostics, radiology, Traditional Chinese Medicine (TCM), and Acupuncture, she is a leading figure in the field. Having studied photo-biomodulation therapy at Weber Institute, Germany, Zulia has gained three decades of experience and has aided numerous patients in achieving pain relief and improved function through advanced laser techniques, including non-invasive 'acupuncture'.

Co-founding 'Recharge' and currently serving as the clinical director, Zulia aspires to make photobiomodulation a household standard, focusing on the promotion of Red Light Therapy through the innovative FlexBEAM device, thus contributing to enhanced well-being and a healthier lifestyle for all.

I LOVE her and her mission!

Topics:

1. Introduction to Photobiomodulation

2. Mechanism of Action: Red and Near Infrared Light

- How red and near infrared light work

- Differences between red and near infrared wavelengths

3. Effects on Mitochondria

- Mitochondrial response to light exposure

- Role of cytochrome c oxidase

- Exclusion zone water and mitochondrial membrane potential

- Increased ATP production

4. Absorption of Light by Other Cells

- Absorption of different light wavelengths (blue, green, yellow, etc.)

5. Other Effects of Red / Near Infrared Light

- Enhancement of blood flow (nitric oxide): Aids in injury Recovery

- Influence on lymph flow

- Effects on collagen

- Fascinating effects on melatonin production (+ experiment analyzing melatonin production even when eyes are covered)

6. Considerations for Light Device Selection

- Specifications of red and near infrared light devices

7. Depth of light penetration

- Impact of wavelength and power density on penetration depth

8. FlexBEAM device: USE CODE "chloeporter" for $60 OFF a FlexBEAM device!

Thanks so much for tuning in!

If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening!

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In today's episode, we are getting granular with the glymphatic system (the lymphatic system of the central nervous system). We are uncovering lifestyle factors that influence brain health and why the brain needs to detoxify in order to maintain a state of sharp cognitition. We even dive into a cutting-edge research study that reports a new way to enhance glymphatic activity even when awake)! Thanks for tuning in!

Topics:

Outline of the Podcast Episode:

1. Updates

- Biohacking Congress in Miami

- Pre-order my book "75 Gut-Healing Strategies & Biohacks"

- GIVEAWAY!

- Gratitude

2. Transition to the Main Topic: Brain Detoxification

- Introduction to brain detoxification and its significance

- Explanation of the glymphatic system and its role in clearing brain waste

- Neurodegenerative diseases (i.e. Alzheimer's Disease)

- Cognitive ability can be impaired if glymphatic system fails to remove toxic metabolites

- Brain cell mitochondrial dysfunction

3. Factors Influencing Brain Detoxification

- Emphasis on the importance of sleep for glymphatic activity

- Sleep quality, quantity, and its impact on brain detoxification

- Influence of sleep position on glymphatic clearance

- Omega-3 fatty acids' effect on glymphatic activity

- Intermittent fasting and its role in enhancing glymphatic clearance

- Benefits of exercise in accelerating glymphatic flow

- Impact of chronic stress on glymphatic function

4. Recent Study: Visual Stimuli and Brain Detoxification

- Discussion of a recent study on visual stimuli's effect on cerebrospinal fluid flow

- Mention of ongoing investigations into potential therapeutic applications (such as for neurodegenerative diseases like Alzheimer's Disease)

5. Conclusion

- Recap of key points about brain detoxification and glymphatic system

Thanks so much for tuning in!

Pre-Order Chloe's Book "75 Gut-Healing Strategies & Biohacks" and email [email protected] a screenshot of the order confirmation to enter the GIVEAWAY!

NEW Research Study

If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening!

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Or visit ⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show!

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Welcome to another episode of The Synthesis of Wellness Podcast! Today, we are talking all about my latest n=1 experiment: using the FlexBeam (a red and infrared light therapy device) on my gut microbiome. Then, we transition into cosmetic peptides with an emphasis on TB-500 for stimulating and accelerating hair growth! Thanks so much for tuning in!

Topics:

1. Introduction

- Biohacking congress in Miami

- Invitation to connect with me for meet-ups and ticket discounts

2. Red and Infrared Light Therapy

- Introduction to the red light and infrared therapy device (FlexBeam)

- Description of the device's features and capabilities

- Explanation of its ability to penetrate up to 10cm within the body

- Interest in exploring the impact of red and near-infrared light on the gut microbiome

- Self-experiment!

3. Scientific Context

- Definition of Photobiomodulation and its healing properties

- Mention of studies exploring the effects of light therapy on the gut microbiome

- Discussion of the impact of Photobiomodulation on gut microbial diversity

4. Human Microbiome Studies**

- Mention of preliminary unpublished work using Photobiomodulation on the human microbiome

- Increases in Akkermansia muciniphila, Bifidobacterium sp., and Faecalibacterium sp.

- Impact on the Firmicutes:Bacteroides ratio as an indicator of gut health

5. Personal Experiment

- Experiment using the FlexBeam device with both red and infrared light

- Explanation of the wavelengths used in the experiment

- Description of the experiment's frequency and duration

- Excitement about the potential results and anecdotal observations

6. Transition to Cosmetic Peptides

- Introduction to the topic of cosmetic peptides

- Focus on thymosin beta-4 and its various uses

7. Thymosin Beta-4 for Hair Growth

- Background information on thymosin beta-4

- Discussion of the hair follicle structure and growth cycle

- Explanation of the anagen, catagen, and telogen phases

- Role of stem cells in the bulge area during anagen phase

- Overview of the acceleration of stem cell migration due to thymosin beta-4

8. Stem Cell Migration and Hair Growth

- Significance of stem cell migration in hair follicle growth

- Natural expression of thymosin beta 4 during anagen phase

- Migration of cells from the bulge to the bulb region

9. Effectiveness and Administration

- Discussion on the effectiveness of thymosin beta-4 for hair growth

- Mention of a study using topical thymosin beta-4 on shaved rats

- Role of angiogenesis in promoting blood flow to the scalp

- Connection between inflammation and decreased blood flow

10. Application Methods

- Topical application in most studies

- Mention of subcutaneous injections for broader repair/regeneration

- Emphasis on working with licensed physicians

11. Conclusion

- Acknowledgment of individual variability in hair growth approaches

- Reminder of the importance of addressing root causes of hair loss

Thanks so much for tuning in!

If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening!

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Today, we have the honor of welcoming Dr. Peg DiTulio to the podcast! Dr. Peg DiTulio is a seasoned shoemaker-certified physician renowned for her expertise in addressing a diverse range of environmental illnesses. Her extensive experience covers conditions such as Tick Borne Diseases (Lyme, Bartonella & Babesiosis), Chronic Inflammatory Response Syndrome (mold toxicity), Methylation Cycle issues, Mast Cell Activation Syndrome, and various gut-related problems.

Employing an Integrative Medical Model, Dr. DiTulio employs a comprehensive approach that involves a blend of pharmaceutical solutions, nutraceutical interventions, lifestyle adjustments, and customized exercise programs. This multi-faceted approach aims to foster overall wellness, and it's a strategy I truly admire.

Topics:

1. Dr. Peg's Background and Commitment to Research

- Exploration of Dr. Peg's background and her focus on Lyme and mold toxicity

2. Mechanisms of Lyme Disease + Coinfections

3. Early vs. Chronic Lyme Treatment

- Consequences of untreated Lyme disease

- Contrast in treatment approach for acute versus chronic Lyme cases

4. Antibiotics in Lyme Treatment

- Discussion of thoughts and considerations on using antibiotics

5. Complications: Chronic Lyme, Mold, and Heavy Metal Toxicity

- Examination of how mold and heavy metal toxicity can complicate chronic Lyme cases

6. Treatment Strategies for Complicated Chronic Lyme

- Exploration of treatment approaches for complex cases of chronic Lyme

- Consideration of treatment order, such as addressing mold before Lyme: reboot the immune system

7. Monitoring Chronic Lyme Recovery

- Discussion of specific blood tests for monitoring the recovery process in chronic Lyme cases

- Visual contrast sensitivity test

8. Diet Considerations: Lyme and Mold

- Exploration of dietary considerations for managing Lyme and mold issues

- Focus on the low amylose diet

9. Healing the Gut and Low MSH

- Strategies to heal the gut, particularly in relation to low MSH leading to leaky gut

If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening!

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Visit ⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

Or visit ⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show!

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In today's episode, we are diving deep into the world of bioregulator peptides, what makes them unique when compared to other peptides, and different peptide stacks for different uses. Thanks so much for tuning in!

Topics:

1. Introduction

- Biohacking Congress Meet-up in Miami

2. Overview of Bioregulator Peptides

- Introduction to bioregulator peptides

- Comparison with other peptide types (e.g., bpc-157)

- Advantages of bioregulator peptides due to size and permeability

- Tissue-specific effects of bioregulators

3. Gene Regulation and Cellular Differentiation

- Explanation of gene regulation's permanent impact on cell differentiation

- Importance of gene expression in cell differentiation but also in the functional activity of the cell

4. Mechanism of Bioregulator Peptides

- Interaction of bioregulator peptides with DNA regions

- Binding to histone proteins at the gene promoter site

- Activation of gene expression and protein synthesis

- Tissue-specificity of bioregulator peptides

5. Discovery and Terminology of Bioregulator Peptides

- Vladimir Khavinson's role in peptide bioregulator discovery

- Extraction of peptides from various tissues

- Introduction of synthetic bioregulator peptides

- Terminology: cytomedines and cytogen

6. Examples of Bioregulator Peptides

- Thymagen: Immunomodulatory effects

- Epithalon (Epitalon): Anti-aging effects and telomere elongation

- Cortagen: Benefits for central nervous system and neuroprotection

- Pancragen: Influence on pancreas / metabolic dysfunction and diabetes

- Pinealon: Neuroprotection, melatonin regulation, circadian rhythm, memory, etc...

7. Potential Applications and Stacking of Bioregulator Peptides

- Discussion on administration methods (injections, sublingual, oral)

- Introduction to an anti-aging stack

- Components of the stack: epitalon, pinealon, BPC-157, NAD+

- Personal preferences on peptide selection

Thanks for tuning in!

Use code CHLOEP for 5% off all ⁠⁠⁠Timeline Nutrition products⁠⁠⁠

If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening!

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Or visit ⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show!

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Today's episode is filled with peptide therapy, informational gems surrounding MOTS-c! We explore how MOTs-c triggers AMPK pathway activation, enhancing fatty acid oxidation and glycolysis, leading to increased ATP production and reduced "fat storage." Additionally, the episode highlights MOTs-c's role in addressing insulin resistance, evident from studies demonstrating lowered glucose and insulin levels in high-fat diet-induced obese mice and reduced menopausal weight gain. Moreover, the peptide's impact on mitochondrial biogenesis and skin health was discussed, emphasizing its potential to combat aging-related issues. Thanks for tuning in!

Topics:

1. Introduction:

- Overview of mitochondria's role in energy metabolism

- Explanation of energy metabolism process

- Importance of mitochondria in energy metabolism and aging

2. MOTs-c: Mitochondrial-Derived Peptide:

- Role of mitochondria's genetic material and protein encoding

- Introduction to MOTs-c and its translocation

- Age-dependent expression and presence of MOTs-c

3. AMPK Pathway Activation by MOTs-c:

- Explanation of AMPK as an energy sensor

- AMPK activation mechanism by MOTs-c

- Resulting increase in fatty acid oxidation and glycolysis

- AMPK's role in inactivating ACC in order to prevent fatty acid storage (more fat "burning," less fat "storage")

4. MOTs-c's Impact on Insulin Resistance:

- Study on high-fat diet-induced obese mice injected with MOTs-c

- Lowered glucose and insulin levels in MOTs-c-treated mice

- Reduced oxidative stress and enhanced cellular stress resistance

- Study on normal and pre-diabetic patients showing lower MOTs-c levels in T2D

5. Mitochondrial Biogenesis and PGC1-alpha Activation:

- Explanation of mitochondrial biogenesis

- Role of PGC1-alpha in mitochondrial health and biogenesis

- AMPK activation by MOTs-c leading to PGC1-alpha transcription

- Stimulation of generation of new, healthy mitochondria

6. MOTs-c's Impact on Aging and Skin Health:

- MOTs-c's influence on increasing NAD+ levels through AMPK activation

- Necessity of NAD+ for longevity-enhancing sirtuins

- MOTs-c's potential to combat age-related decline in NAD+

- Study indicating MOTs-c's potential in preventing skin aging

7. MOTs-c and Menopause:

- MOTs-c's potential in reducing weight gain and insulin resistance in menopause

- MOTs-c's effects on enhancing insulin sensitivity

8. Peptide Therapy Using MOTs-c:

- Explanation of peptide therapy and MOTs-c administration

- Caution and recommendation to work with licensed peptide physicians

9. Boosting Endogenous MOTs-c Production:

- Human studies showing MOTs-c increases through exercise

- Combination of exercise and peptide therapy for enhanced MOTs-c synergy

- Personal experience with mitochondrial-focused therapies: an example stack

Thanks for tuning in!

Use code CHLOEP for 5% off all ⁠⁠Timeline Nutrition products⁠⁠

If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening!

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Visit ⁠⁠⁠synthesisofwellness.com⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

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Today, we have the pleasure of welcoming Dr. Barrie Tan to the show. Dr. Tan's academic journey led him to earn his Ph.D. in Chemistry/Biochemistry from the University of Otago, and he also served as a professor at UMass. Dr. Tan's remarkable contributions have solidified his position as a trailblazer and the foremost expert in the realm of vitamin E. His relentless passion drives him to delve into the exploration and enhancement of phytonutrients that hold the promise of mitigating chronic ailments.

Topics:

1. Distinguishing Tocopherols from Tocotrienols

- Exploring chemical structures of tocopherols and tocotrienols

- Understanding their respective roles as antioxidants

2. Dr. Tan's Annatto Plant Discovery

- Unveiling Dr. Tan's breakthrough in the realm of tocotrienol research

- Shedding light on the significance of the annatto plant

3. Early Tocotrienol Studies and Health Insights

- Discussing initial research findings

4. Evaluating Potential Concerns with Tocopherols

- Examining the possible detrimental effects of tocopherols

- Considering drawbacks and contrasting with tocotrienol benefits

5. Tocotrienols' Impact on Cardiovascular Well-being

- Analyzing the contribution of tocotrienols to cardiovascular health

- Uncovering mechanisms driving positive cardiovascular effects

6. Tocotrienols and Inflammation Reduction

- Elaborating on the connection between tocotrienols and inflammation

- Identifying specific inflammation markers influenced by tocotrienols

7. Tocotrienols' Role in Metabolic Health

- Investigating tocotrienols' role in metabolic syndrome and diabetes management

- Examining how tocotrienols affect metabolic health

8. Recommended Usage and Dosage of Tocotrienols

- Addressing potential variations in dosage based on health conditions

9. Exploring Geranylgeraniol: A Brief Conversation on What It Is and Its Health Benefits

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If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening!

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In this episode, we're delving into the fascinating world of sirtuins, exploring their role in countering the 9 hallmarks of cellular aging, and uncovering ways to optimize their activity for our benefit. We'll be exploring 7 proven strategies, backed by scientific research, that can effectively boost the expression of these longevity-promoting sirtuins within the body.

Topics:

1. Introduction

- Overview of NAD+ and its role in energy metabolism

- Previous discussion on strategies to increase NAD+ levels

- Importance of NAD+ in other reactions such as those mediated by sirtuins

2. Sirtuins: Introduction and Background

- Definition and origin of the term "sirtuins"

- Discovery of sirtuins and their role in yeast aging

- Transition from yeast cells to mammalian cells

- Introduction to SIRT1 as a focus for exploration

3. SIRT1: NAD+-Dependent Histone Deacetylase

- Role of SIRT1 as an NAD+-dependent histone deacetylase

- Gene silencing / gene expression

- SIRT1's influence on "genome stability" mediated by its ability to silence genes

4. SIRT1's Multi-Faceted Activities

- Beyond histone deacetylation: SIRT1's reach to non-histone proteins

- Deacetylation of p53 and suppression of cellular senescence

- Enhancement of telomere integrity

- Connecting these activities back to those 9 hallmarks of aging

5. The Sirtuin Enhancement Toolkit for Longevity: 7 Strategies

- Resveratrol and Pterostilbene

- Increasing NAD+ availability through various methods

- Exercise's influence on SIRT1 expression

- DHA (Omega-3 fatty acid) and its role in activating SIRT1

- Zinc's importance for SIRT1's structural integrity and function

- Nutraceuticals: Berberine, quercetin, fisetin, and curcumin

- Intermittent fasting and its impact on NAD+ levels and SIRT1

Thanks for tuning in!

If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening!

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