August 07, 2025

#221 Inside The Revolutionary Epigenetic Cellular Health Test (1700 Biomarkers from a Single Drop of Blood) | Ryan Smith @ TruDiagnostic

1 hour 2 minutes

Standard blood tests barely scratch the surface.

Ryan Smith shares how TruDiagnostic’s TruAge & TruHealth tests use over 1,700 biomarkers from just a drop of blood to measure biological age, hormone health, immunity & more. Go beyond standard labs & start bioharmonizing with cutting-edge precision so you can make decisions that actually impact how you feel & age.

Meet our guest

Ryan Smith studied Biochemistry at Transylvania University before founding Tailor Made Compounding, which became one of the fastest-growing healthcare companies in the U.S. After exiting in 2020, he launched several ventures, including TruDiagnostic, a CLIA-certified lab specializing in methylation-based diagnostics for longevity & preventive health.

TruDiagnostic leads the field with one of the largest private epigenetic databases, over 13,000 patients, & active participation in 30+ clinical research studies. Ryan remains a key figure in advancing functional medicine through innovative health data solutions.

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Key takeaways

Biological age gives a clearer picture of health risk than birthdate by showing how your body is actually aging

Lifestyle basics like exercise, clean eating, stress reduction & social connection remain top tools for aging well

Some biological age tests are more reliable thanks to stronger prediction power & actionable results

Longevity interventions can now be ranked using technology that tracks measurable improvements over time

Leading tests don’t just score your age but give clear next steps to improve healthspan & lifespan

DNA methylation data offers biomarker proxies that sometimes outperform traditional blood tests

Methylation-based tests bring better precision & consistency than standard lab results affected by daily shifts

Immune system strength plays a major role in aging by influencing inflammation & clearing damaged cells

Supplement & lifestyle tracking tools now show whether specific changes are actually improving key health markers

TruAge tests work well for most while biohackers may benefit more from deeper panels like the TruHealth test

Episode Highlights

3:29 What Biological Age Really Tells You

10:12 Inside TruDiagnostic’s Testing Framework

11:39 Key Lifestyle & Supplement Insights from the Data

15:10 How to Interpret Your Report & Take Action

30:12 Understanding Your Immune & Metabolic Health

45:29 Practical Application & Future of Epigenetic Testing

Links

Watch it on YouTube: https://youtu.be/MykPl4fZ3Sc

Full episode show notes: outliyr.com/221

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By Nick Urban | Longevity, Biohacking, & Performance

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