August 14, 2025

#222 Biohack Your Gut & Restore Your Microbiome For Ultimate Wellness | Dr. Vincent Pedre @ Happy Gut

1 hour 13 minutes

Think your gut health only affects digestion?

From fermented foods and targeted probiotics to peptides like BPC157, Dr. Vincent Pedre shares practical ways to rebuild microbiome balance and boost overall performance.

Meet our guest

Dr. Vincent Pedre is the Medical Director of Pedre Integrative Health & CEO of Happy Gut Life, with over 25 years of clinical experience as a Functional Medicine-certified practitioner & gut biohacker. He’s the bestselling author of Happy Gut & he GutSMART Protocol, a 14-day personalized gut-healing plan. His latest creation, Happy Gut Coffee, is a clean, toxin-free brew that supports gut health & boosts energy from the first sip.

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Key takeaways

Antibiotics in childhood cause long-term gut problems. Fixing your gut requires targeted effort, no matter when the damage began

Certain gut infections like E. coli trigger autoimmune responses, leading to chronic gut issues like IBS & leaky gut

Taking multi-strain probiotics while on antibiotics helps your gut recover faster than waiting until after the antibiotics

Regularly eating fermented foods strengthens the immune system, reduces inflammatory markers, & boosts gut microbiome diversity

Short-term carnivore diets help people with severe bloating, SIBO, or trouble digesting vegetables, giving their gut a break

Reintroduce vegetables slowly, beginning with fermented ones—they’re easier to digest & support rebuilding your gut flora

Oral peptides like BPC157 & lorazatide repair tight junctions, reduce food sensitivities, & speed up gut healing

Many chronic health issues trace back to hidden parasites, even if you don’t have gut symptoms Proper testing is key

Short chain fatty acid butyrate made by gut bacteria heals the colon, reduces inflammation, & helps the brain

Choose organic, mold-free coffee to protect your gut from pesticides, mycotoxins, & microplastics while getting gut-healthy polyphenols

Episode highlights

01:21 How Antibiotics Damage the Gut

10:04 How to Restore Your Gut After Taking Antibiotics

18:11 Safely Reintroducing Foods & Fermented Products for Gut Healing

26:03 Dr. Pedre’s CARE Gut Healing System

35:46 The Connection Between Gut Health & Mitochondria

Links

Watch it on YouTube: https://youtu.be/m5lvpsituus

Full episode show notes: outliyr.com/222

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By Nick Urban | Longevity, Biohacking, & Performance

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