August 28, 2025

#224 10X Your Longevity Strategy by Saying NO to Over-Optimization | Blair @ Buck Institute

1 hour 12 minutes

Could saying no actually be your best longevity strategy?

Blair LaCorte reveals why avoiding over-optimization and focusing on system biology, compassion, and purpose instead leads to authentic biosynergy and lasting vitality.

Meet our guest

Blair LaCorte is a dynamic business executive whose career spans entertainment, aviation, AI, technology, aerospace, consulting, investing & military logistics. He has held CEO & C-level roles at leading companies like PRG, XOJET/Vista, TPG, Autodesk & Oracle, while also taking startups such as AEye Technologies & VerticalNet to IPO. Currently an astronaut-in-training with Virgin Galactic & Vice Chairman of the Buck Institute, Blair continues to drive innovation, growth & global impact.

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Key takeaways

Tech is for control, not a cure all Forgetting biology leads to problems, not progress

Over optimizing health with gadgets causes new problems Step back & look at the whole picture

Scientific knowledge & personal belief both affect your biology & well being more than most realize

Staying healthy is better than only reacting to sickness Small daily choices matter more than silver bullets

Focus on what works for you Test, observe, & stick with what fits your life & makes you feel good

Relationships lower stress & boost your immune system Loneliness is a major health risk at any age

Some stress helps growth Chronic unbroken stress harms your body Find ways to activate & calm yourself

Knowing health tips isn’t enough Build habits you enjoy, ideally with friends or community support, for lasting results

No two people are alike Track your own changes & work out routines & diets that fit you specifically

Modern testing makes it easier to spot issues early Keep personal health records to track your biomarkers over time

Episode highlights

04:19 Why Technology Alone Won’t Save Your Health

21:17 The Real Framework for Habit Change That Works

28:50 What Truly Multiplies Healthspan Results

36:44 Practical Ways to Strengthen Connection & Reduce Stress

46:28 How to Personalize Health in a Complex World

Links

Watch it on YouTube: https://youtu.be/U2QuhPEugq4

Full episode show notes: outliyr.com/223

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Nick

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By Nick Urban | Longevity, Biohacking, & Performance

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