Are you curious about how cocaine works in the body and the secrets behind successful drug testing? Look no further! In this eye-opening video, I delve deep into cocaine's kinetics, covering everything from absorption and distribution to metabolism and excretion. We explore how various routes of administration—like snorting, smoking, and injection—affect cocaine's absorption rate and the resulting emotional highs. Learn why bioavailability is greatest through inhalation and intravenous use, and discover the factors influencing this potent drug's absorption and distribution.We also highlight crucial information on cocaine metabolism, including its breakdown into metabolites like benzoylecgonine, norcocaine, and cocaethylene. You will learn why certain combinations, such as cocaine with alcohol, can lead to detrimental effects and prolonged drug detection times. Armed with this knowledge, you'll better understand the intricacies of urine drug testing and how metabolites linger in the system for days to weeks, depending on user habits.Chapters00:00:00 Introduction to Cocaine Kinetics00:00:47 Cocaine Absorption Methods00:01:48 Distribution of Cocaine00:02:35 Cocaine Metabolism00:04:22 Metabolic Pathways and Key Harm Reduction Intervention00:05:21 Detailed Metabolites of Cocaine00:07:06 Half-Life of Cocaine and Its Metabolites00:08:17 Detection Methods for Cocaine in Biological Matrices00:09:03 Overview of Biological Matrices for Cocaine Detection00:10:47 Considerations for Cocaine Detection00:11:27 Implications for Drug Testing00:12:07 Conclusion and Next Episode Preview

Join Addiction medicine specialist Dr. Ferghal Armstrong as he demystifies the complexities surrounding cocaine and its various forms. Derived from the coca plant native to South America, cocaine is a drug that has captivated cultures for centuries—both for its ceremonial use by indigenous peoples and its controversial place in modern society. Dr. Armstrong walks you through the historical context of cocaine, its initial uses, and the evolution of its reputation from a local anaesthetic to a highly addictive substance.Discover the clinical effects that draw individuals to use cocaine, from the euphoric highs to the concerning long-term health risks such as cardiovascular problems, mental health issues, and physical deterioration. Learn about the distinct processes that differentiate cocaine hydrochloride, the easily snorted or injected powder, from freebase cocaine and crack cocaine, both of which are smokable and deliver an even more rapid high.With insights into the risky manufacturing methods and the physicochemical properties that influence how cocaine is consumed, this video encourages viewers to reflect on the profound impact this drug has on individuals and communities. Prepare to gain knowledge, awareness, and a sharper understanding of the intricacies of cocaine addiction in this first episode of the Cracking Addiction series.Chapters00:00:00 Introduction to Cocaine and Its Forms00:01:08 Historical and Medical Background of Cocaine00:02:20 Risks and Long-term Effects of Cocaine Use00:03:31 Cocaine Production: From Plant to Powder00:04:33 Understanding Cocaine Hydrochloride00:05:50 Insights into Freebase Cocaine00:07:24 Exploring Crack Cocaine00:08:14 Differentiating the Forms of Cocaine00:09:51 Conclusion and Key Takeaways

If you're struggling with benzodiazepine withdrawal, this video shares safe tapering strategies to help you ditch the anxiety and regain control. Learn about benzodiazepine induced neurological dysfunction (BIND) and how to overcome it.

If you're experiencing BIND from benzodiazepines, watch out for these alarming signs of neurological dysfunction and cognitive impairment. This video will help you understand the risks of long-term benzodiazepine use.

Are you struggling with benzodiazepine dependence, looking to understand their impact, or need tips on tapering off? You’ve come to the right place! In this episode of "Cracking Addiction," I delve deep into the world of benzodiazepines, exploring their role in cognitive impairment, addiction potential, and their crucial use in alcohol withdrawal management. With keywords like benzodiazepines, addiction, and alcohol withdrawal, this video is a must-watch for anyone dealing with these powerful medications.

In this eye-opening episode of Cracking Addiction, we delve deep into the intricate world of benzodiazepine withdrawal and its impact on chronic pain and anxiety. If you've ever struggled with benzodiazepine use or are curious about how these medications work, this video is for you! 🌟 Discover the critical differences between clinical tolerance and dependence, and understand why the Royal College of Psychiatrists advises limiting benzodiazepine use to no more than one month.

Discover the fascinating world of benzodiazepines as we break down their metabolism, kinetics, and clinical impact. In this episode, we explore how the liver processes these commonly prescribed medications, highlighting the critical role of the cytochrome P4503A4 system. Learn why some benzodiazepines bypass phase 1 oxidation and how this affects their safety in elderly patients or those with liver disease.

Dive deep into the fascinating world of benzodiazepines with Dr. Ferghal Armstrong as we explore how these commonly prescribed medications function, their effects on the brain, and their clinical uses. Learn about the science behind GABA modulation, the differences between benzodiazepines and barbiturates, and why benzodiazepines are considered safer. We’ll uncover the secrets of their potency, half-lives, and why they’re used for conditions like anxiety, insomnia, and withdrawal management.

Loneliness can have serious effects on your body. In this video, we'll explore the impacts of loneliness on your health and what you can do to combat it. Discover how social connections, resilience, and avoiding substance use disorder can help improve your well-being.

n this powerful interview, Dr. Samantha Harte reveals what nobody tells you about turning pain into power. She shares her journey through addiction recovery, mental health struggles, and the importance of a 12-step program. If you're a sober mom or struggling with substance abuse, this interview is a must-watch for insights and inspiration.