In this episode, we are joined Dr. Dominic D’Agostino, Ph.D. He is an Associate Professor with tenure at the University of South Florida where he teaches students of the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology, with a focus on such topics as neuropharmacology, medical biochemistry, physiology, neuroscience, and neuropharmacology. He is also a Research Scientist at the Institute for Human and Machine Cognition(IHMC) to assist with their efforts towards optimizing the safety, health and resilience of the warfighter and astronaut.   Dr. D’Agostino chats with host Dr. Scott Sherr on manta rays being ketogenic, his early research in the field of oxidative stress, ketones in cancer, ketones and its effect on mitochondrial function, ketones and epigenetics, and so much more.   What we discussed: 00:00:22 - Introduction 00:02:12 - Manta Rays are ketogenic 00:03:54 - Is it common for fish to use ketones as fuel? 00:05:22 - How Dr. D’Agostino got into the ketogenic diet 00:08:49 - Oxidative stress 00:09:49 - Ketones in cancer 00:13:12 - The ketogenic diet 00:14:56 - The protein sparing modified ketogenic diet 00:16:24 - How Dr. D’Agostino got involved in the optimal performance world 00:19:53 - Ketones and its effects on mitochondial function 00:27:11 - Ketones and Epigenetics 00:30:43 - Dr. D’Agostino’s thoughts on ketones over the years 00:34:02 - The mechanism of a ketone induced increase in insulin 00:38:18 - Maintaining ketosis for long periods of time 00:45:07 - The Ketogenic diet and neurotransmitters 00:54:16 - Effects of long term ketogenic diets of menstrual cycle 00:56:26 - Ketonegic diet and microbiome 01:01:49 - The best way to keep your glucose from spiking 01:04:11 - Ketogenic diet and endocannabinoid system 01:07:21 - Dr. D’Agostino’s exciting project on metabolic psychiatry   Find more from Smarter, Not Harder: Website: https://troscriptions.com/blogs/podcast / https://homehope.org Instagram: @troscriptions | @homehopeorg   Find out more about Dr. Dominic D’Agostino: Website: https://ketonutrition.org/ Website: https://linktr.ee/Domdagostino Twitter: https://twitter.com/dominicdagosti2 Instagram: https://www.instagram.com/dominic.dagostino.kt/     Get 10% Off Your Purchase of Metabolomics Module by using PODCAST10 at https://www.homehope.org   Get 10% Off your Trosciptions purchase by using POD10 at https://www.troscriptions.com   Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.