Physionic

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Original Podcast: https://youtu.be/q57CNySsYxs?si=PIwVEVGj_-cYkDCU0:00 - Introduction1:54 - Genetics that cause High Cholesterol5:29 - The American Heart Association is lying to you8:05 - Extremely High Cholesterol doesn't Kill17:48 - High Cholesterol at 60? Protection from Death25:20 - Other ways of testing this?27:12 - Main PointsReferences[1] Mundal L, Sarancic M, Ose L, et al. Mortality among patients with familial hypercholesterolemia: a registry-based study in Norway, 1992–2010. *J Am Heart Assoc*. 2014;3(6):e001236. doi:10.1161/JAHA.114.001236[2] Brown MS, Goldstein JL. Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. *Proc Natl Acad Sci U S A*. 1974;71(3):788-792. doi:10.1073/pnas.71.3.788[3] Shishikura D, Harada-Shiba M, Michikura M, et al. Comparison of clinical characterization and therapeutic strategies between homozygous familial hypercholesterolemia and heterozygous familial hypercholesterolemia. *J Atheroscler Thromb*. 2026;33. Advance publication online March 27, 2026. doi:10.5551/jat.65959[4] Wiegman A, de Groot E, Hutten BA, et al. Arterial intima-media thickness in children heterozygous for familial hypercholesterolaemia. *Lancet*. 2004;363(9406):369-370. doi:10.1016/S0140-6736(04)15467-6[5] EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC). Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC). *Lancet*. 2021;398(10312):1713-1725. doi:10.1016/S0140-6736(21)01122-3[6] Clarke R, Emberson JR, Parish S, et al. Cholesterol fractions and apolipoproteins as risk factors for heart disease mortality in older men. *Arch Intern Med.* 2007;167(13):1373-1378.[7] Ding M, Wennberg A, Ek S, et al. The association of apolipoproteins with later-life all-cause and cardiovascular mortality: a population-based study stratified by age. *Sci Rep.* 2021;11(1):24440. doi:10.1038/s41598-021-03959-5.[8] Mortensen MB, Nordestgaard BG. Elevated LDL cholesterol and increased risk of myocardial infarction and atherosclerotic cardiovascular disease in individuals aged 70-100 years: a contemporary primary prevention cohort. *Lancet*. 2020;396(10263):1644-1652. doi:10.1016/S0140-6736(20)32233-9Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderMain Analysis: https://www.youtube.com/watch?v=e2_9mHtWwBQ0:00 - Introduction0:36 - Peptides on Cardiovascular Disease1:25 - Ceramides!3:44 - One Ceramide to instill Fear in All!6:16 - Returning to PeptidesReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1022] Lincoff AM, Brown-Frandsen K, Colhoun HM, et al; SELECT Trial Investigators. Semaglutide and cardiovascular outcomes in obesity without diabetes. N Engl J Med. 2023;389(24):2221-2232. doi:10.1056/NEJMoa2307563[Study 998] Lundgren JR, Janus C, Jensen SBK, et al. Healthy weight loss maintenance with exercise, liraglutide, or both combined. N Engl J Med. 2021;384(18):1719-1730. doi:10.1056/NEJMoa2028198[Study 999] Sandsdal RM, Holt J, Alkhefagie HGA, et al. Effects of exercise and liraglutide on vascular health and inflammation during weight loss maintenance: a prespecified secondary analysis of the S-LiTE trial. Nat Metab. 2026;8:1483-1488. doi:10.1038/s42255-026-01554-4[Study 1000] Mashayekhi M, Beckman JA, Nian H, et al. Comparative effects of weight loss and incretin-based therapies on vascular endothelial function, fibrinolysis, and inflammation in individuals with obesity and pre-diabetes: a randomized, controlled trial. Diabetes Obes Metab. 2023;25(2):570-580. doi:10.1111/dom.14903.[Study 1001] Akawi N, Checa A, Antonopoulos AS, et al. Fat-secreted ceramides regulate vascular redox state and influence outcomes in patients with cardiovascular disease. J Am Coll Cardiol. 2021;77(20):2494-2513. doi:10.1016/j.jacc.2021.03.314Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

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0:00 - Introduction4:43 - Berberine on Colorectal Cancer21:36 - 5 Free Health Tests1:03:15 - Glycine Restriction and Cancer1:39:12 - Favorite Anti-Aging Hack2:06:00 - Lithium on Alzheimer's Disease2:29:20 - Vitamin K on Cardiovascular Disease3:14:00 - Housekeeping/Hanging Out

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0:00 - Introduction

4:02 - Collagen for Skin 'Debunked'

36:30 - Ketones track with Liver Disease

52:15 - Butyrate and Cancer

1:25:50 - Seed Oils - Harmful?

1:59:55 - Ineffective Creatine

2:17:17 - Non-Nutritive Sweeteners and Cognitive Decline

2:42:39 - Housekeeping, Updates, Hangout

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0:00 - Introduction

1:18 - What is NAD+? Why is it Important?

8:39 - Weight Loss and NAD+

16:25 - The Dr. Sinclair Story

24:30 - Dr. Sinclair's focus on NAD+

31:50 - How have Scientists boosted NAD+?

34:09 - Do NAD+ Boosters work?

45:36 - Different types of NAD+ Boosters

49:40 - Dr. Sinclair's newest NAD+ Study (Unpublished!)

1:05:28 - Exercise and other Strategies for NAD+ Boosting

1:10:15 - NAD+ in Women

1:13:55 - Nuchido Time+ NAD+ Study in Humans

1:29:51 - Summarizing/Take Aways

1:34:08 - Taking Niacin instead of other NAD+ Boosters?

1:38:05 - Conclusion/Just Chatting

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1:15:20 - Lipid Heart Model of Heart Disease

1:27:28 - Lean Mass Hyper-Responders

1:35:10 - Mechanisms of Action Discussion

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Dr. Stanfield's Channel: https://www.youtube.com/@DrBradStanfield

Timestamps

0:00 – Introduction

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