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In this episode, Leigh Ann welcomes Fatty15 Principal Scientific Educator Sharlyne Poggio for a deep dive into C15:0, an odd-chain saturated fatty acid being studied for its role in cellular health and healthy aging. Sharlyne shares the unusual origin story of C15 research, beginning with aging Navy dolphins whose metabolic and health markers changed alongside shifts in dietary C15. Together, they break down what C15 is, where it comes from, and why researchers are investigating its relationship to red blood cell stability, mitochondrial function, inflammation, metabolism, and cell membrane integrity. The conversation explores ferroptosis, an iron-dependent form of cell death, and the emerging theory that inadequate C15 may contribute to cellular fragility and downstream dysfunction. Leigh Ann and Sharlyne also discuss blood sugar, AMPK and longevity pathways, dairy quality, C15 testing, and some of the early questions researchers are asking about C15 in areas such as liver health and cancer biology. They close with practical information on Fatty15 supplementation, testing C15 levels, and why supporting cellular function may offer a more upstream lens for thinking about long-term health.
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Leigh Ann welcomes therapist Holly Baxter for a depth psychology-based exploration of menopause as a physical, emotional, relational, and deeply transformative threshold. Holly shares how her own experience with cancer and medically induced menopause eventually shaped her work with women navigating midlife transitions, many of whom arrive in therapy feeling misunderstood, pathologized, or told that they are suddenly “not themselves.” Together, Leigh Ann and Holly explore menopause as a developmental passage that can disrupt long-held roles around caregiving, partnership, motherhood, usefulness, and identity while bringing previously buried parts of the self closer to the surface. They discuss shadow, individuation, resentment, boundaries, relationship changes, grief, creativity, and the fear that can arise when the people around us are challenged by who we are becoming. Holly also offers a symbolic lens for experiences like hot flashes, brain fog, anger, and the end of the menstrual cycle, asking what may be ready to be released, reclaimed, or consciously redirected during this stage of life. The conversation ultimately holds both the psychological and physiological realities of menopause, including the role of hormone therapy, strength training, nutrition, sleep, and medical support alongside the deeper inner work of becoming more fully ourselves.
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In this episode, Leigh Ann welcomes Dr. Chris Molda for a conversation on chronic infection, detoxification, Lyme, mold, parasites, zeolite, bacteriophages, and what happens when even integrative protocols fail to move the needle. Dr. Molda shares his own experience becoming severely ill after a convergence of mold exposure, Lyme, parasites, and COVID, despite already having years of experience in functional medicine and access to many of the protocols he was trying himself. He explains why his own sensitivity eventually pushed him toward a simpler approach, beginning with high-dose zeolite as a binder intended to reduce toxic burden without asking an already overwhelmed body to do more work. Leigh Ann and Dr. Molda then explore bacteriophages and the signaling therapy he uses to target specific infections, along with his perspective on why this approach may create less collateral damage than broader antimicrobial strategies. They also discuss the emotional aftermath of chronic illness, the fear that can develop after years of severe reactions, and why removing an infection does not automatically resolve the nervous system patterns created while someone was sick.
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Leigh Ann welcomes Dr. Amy Myers for a conversation on autoimmunity, functional medicine, trauma, gut health, environmental exposures, infections, and the upcoming revised edition of The Autoimmune Solution. Dr. Myers shares how her own experience with Graves disease, conventional treatment, and eventually discovering functional medicine shaped her career and her mission to understand what drives autoimmune disease beneath the diagnosis. She revisits the core pillars of The Myers Way, including healing the gut, changing inflammatory dietary inputs, reducing toxic exposures, addressing latent infections, managing chronic stress, and now placing greater emphasis on trauma. Leigh Ann and Dr. Myers explore why people with the same diagnosis may have very different combinations of contributing factors and why chronic illness rarely comes down to one isolated cause. Dr. Myers also discusses some of the topics she has added to the revised edition, including COVID, newer wellness modalities, plasmapheresis, and the growing recognition of the relationship between trauma, inflammation, and chronic disease.
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Leigh Ann welcomes Dr. Scott Sherr back to The Accrescent for a deeper conversation on methylene blue and its role in mitochondrial function, cellular energy, detoxification, chronic illness, and cancer support. Dr. Sherr explains the history of methylene blue and how its ability to support electron flow within the mitochondria can create an energetic “floor” for people whose cells are struggling to produce enough energy. Leigh Ann and Dr. Sherr explore why this matters in complex chronic illness, where mold, Lyme, inflammation, medications, chronic stress, and other factors may all contribute to mitochondrial dysfunction. They also discuss methylene blue’s dose-dependent antimicrobial properties and why supporting mitochondrial capacity first may help chronically ill patients better tolerate more intensive detox or antimicrobial protocols later. The conversation takes a nuanced look at methylene blue in cancer care, including why timing may matter around oxidative therapies like chemotherapy and radiation and how it may be used differently during treatment versus recovery. Dr. Sherr also breaks down the different Troscriptions methylene blue products, how he approaches dosing and titration, and why he often combines mitochondrial support with nervous system regulation.
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Leigh Ann welcomes Brad Pitzele, founder of One Thousand Roads, for a conversation on exercise with oxygen therapy, or EWOT, and the role oxygen plays in cellular energy, inflammation, detoxification, and recovery. Brad shares his own history with psoriasis, autoimmune arthritis, melanoma, Lyme disease, Bartonella, debilitating pain, and years of treatments that failed to meaningfully improve his health before oxygen therapy became an important part of his recovery. He explains how EWOT combines cardiovascular movement with high-concentration oxygen to increase circulation and oxygen delivery, particularly into tissues that may have compromised microcirculation. Leigh Ann and Brad also compare EWOT with hyperbaric oxygen therapy and oxygen nanobaths, exploring the practical and physiological differences between these approaches. They discuss how oxygen availability affects mitochondrial energy production, inflammation, detoxification, sleep, exercise capacity, and the body’s ability to repair itself, along with why chronically ill patients may need to ease into the therapy slowly. Brad also explains the potential synergy between EWOT and red light therapy, using oxygen first to increase supply and red and near-infrared light afterward to stimulate mitochondrial oxygen utilization.
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Leigh Ann welcomes Dr. Lori Bouchard back to The Accrescent Podcast to explore a part of the cancer journey that often gets overlooked - what happens after treatment ends and the scans finally look clear. Dr. Bouchard explains why people can be in remission or have no evidence of disease and still struggle with exhaustion, brain fog, neuropathy, depression, anxiety, hormone disruption, immune weakness, digestive issues, and a general feeling that their body has not recovered. Together, they unpack some of the downstream effects of chemotherapy, radiation, surgery, contrast imaging, chronic inflammation, nutrient depletion, gut disruption, heavy metals, and immune suppression. They also discuss why dormant infections, mold, hormonal imbalances, and metabolic dysfunction may become more apparent after the body has been through intense treatment. Dr. Bouchard shares how individualized testing and data can help guide post-cancer support, rather than relying on standard blood work or a one-size-fits-all recovery plan. This conversation offers a hopeful perspective for anyone who has made it through cancer treatment but is still asking, “Why don’t I feel better yet?”
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Leigh Ann welcomes licensed clinical social worker Lisa Arrigo for a conversation on complex trauma, addiction, generational patterns, nervous system survival, and the parts of us that form in response to pain. Lisa shares how her own complicated upbringing, cocaine addiction, recovery, and long healing journey led her into psychology, social work, trauma-informed treatment, and a desire to help people understand the neurobiology beneath their patterns. Leigh Ann and Lisa explore how trauma can begin before conscious memory, including in utero experiences, birth trauma, attachment wounds, generational inheritance, and the early danger signals that shape the nervous system. They discuss complex trauma, addiction, dissociation, parts work, internal protector strategies, and why behaviors that look self-sabotaging are often survival adaptations trying to protect us. Lisa also shares honestly about what helped and what did not in her own recovery, including traditional talk therapy, 12-step recovery, psychoanalysis, EMDR training, somatic work, IFS, and trauma-informed therapy.
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In this episode, Leigh Ann welcomes Dr. Michael Bagnell for a conversation on functional neurology, brain injury rehabilitation, migraines, dizziness, neuroinflammation, and what conventional neurology may overlook. Dr. Bagnell shares how his background in chiropractic, physical medicine, applied kinesiology, and brain injury rehabilitation shaped his brain-based approach to healthcare. He explains why symptoms like migraines, chronic headaches, dizziness, light sensitivity, brain fog, anxiety, depression, and cognitive changes often require a deeper look at brain function rather than only imaging, medication, or broad diagnoses. Leigh Ann and Dr. Bagnell discuss how tools like eye-tracking goggles, vestibular testing, QEEG brain mapping, autonomic testing, and multi-axis rotational chair assessments can reveal functional patterns that standard exams may miss. They also explore how concussions, emotional trauma, mold, Lyme, mast cell activation, chronic inflammation, sleep issues, and stress can layer over time and affect the brain’s resilience. This episode reframes brain healing as an active rehabilitation process, where supporting the metabolic environment matters, but targeted neurological stimulation may be needed to help injured or underperforming pathways come back online.
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Leigh Ann welcomes Osteoboost CEO Laura Yecies, who explains the difference between osteopenia and osteoporosis, why knowing your bone-density baseline can be valuable, and why she believes women should become proactive about their bones earlier in life. Bone health is often overlooked until osteoporosis or a fracture occurs, but significant bone loss can begin much earlier—especially during the menopausal transition. Laura also shares her personal experience losing 13% of her bone density between ages 52 and 57 and how it shaped her commitment to finding better preventive options. We explore Osteoboost, an FDA-cleared prescription wearable that uses targeted vibration at the hips and lumbar spine to help reduce bone-density loss in postmenopausal women with osteopenia. The conversation offers a broader look at how screening, exercise, nutrition, medical care, and emerging non-drug interventions may help women preserve bone strength, mobility, and independence as they age.
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