The Plus SideZ: A GLP-1 Guide to Metabolic Health

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What if millions of women with PCOS were misunderstood for years because the condition was treated mainly as a reproductive disorder instead of a metabolic disease tied to insulin resistance, obesity, hormones, and fertility?

In this episode of The Plus SideZ Podcast, Dr. Melanie Cree, a pediatric endocrinologist, obesity researcher, and PCOS/PMOS expert, explains the recent global consensus to rename PCOS to PMOS, or Polyendocrine Metabolic Ovarian Syndrome, to better reflect the condition’s metabolic and hormonal impact.

Dr. Cree breaks down how delayed diagnosis and outdated understanding may have prevented many patients from getting earlier metabolic treatment and intervention.

We discuss:
Why so many women with PCOS were misunderstood or dismissed
The connection between PCOS, PMOS, insulin resistance, obesity, and fertility

• Why weight gain is not just about willpower
• Adolescent PCOS and why early intervention matters
• GLP-1 medications like semaglutide for PCOS/PMOS
• Emerging research focused on ovulation, fertility, and metabolic health
• How hormones, appetite, and metabolism are connected
• Why the PMOS name change could improve diagnosis and treatment

Dr. Cree also shares information about her ongoing research and studies exploring how GLP-1 medications may help improve metabolic and reproductive health in people with PCOS/PMOS.

Learn more about studies 
https://medschool.cuanschutz.edu/pediatrics/sections/endocrinology/endocrinology-research/cree-lab/Cree-Melanie-UCD4665?utm_source=chatgpt.com

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This week, we’re revisiting one of the most powerful conversations in Plus SideZ Podcast history with Rosie O'Donnell.

As Kim takes time away following the loss of her sister, we’re sharing a few meaningful “greatest hits” episodes that continue to resonate deeply with listeners. Thank you for continuing to support, download, watch, and share the podcast during this difficult time. This community means more than you know.

In this replay, Rosie opens up about:

- Lifelong struggles with weight and obesity
- How the media treated her body over the years
- Bariatric surgery and her experience after surgery
- Emotional eating, shame, and public scrutiny
- What it feels like to navigate weight and health over 60
- Her experience with GLP-1 medications and changing obesity treatment

As conversations around GLP-1 medications continue to grow, especially with major Medicare coverage changes expected to expand in July 2026, this episode feels more relevant than ever. For many adults over 60, questions about obesity treatment, metabolism, bariatric surgery, and whether GLP-1s can still work after decades of dieting are finally entering the mainstream.

This episode goes beyond headlines and before-and-after stories. It’s an honest conversation about biology, stigma, survival, and what happens when people living with obesity are finally heard with compassion instead of judgment.

If you’ve ever wondered:

- Do GLP-1 medications work differently over 60?
- Can GLP-1s help after bariatric surgery?
- Why does weight loss feel harder with age?
- How much of obesity is biology versus willpower?

…this conversation is for you.

Listen now wherever you get your podcasts and subscribe to The Plus SideZ Podcast for more conversations that validate lived experience with science, honesty, and empathy.

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#Mounjaro #MounjaroJourney #Ozempic #Semaglutide #tirzepatide  #GLP1 #Obesity #zepbound #wegovy

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Kim Carlos, Executive Producer 

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Kat Carter,  Producer 

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Linktree for Community Resources

Need help appealing your GLP-1 insurance denial? Try Honest Care!
www.findhonestcare.com/Kim

Ro - Telehealth for GLP1 Weight Management
https://ro.co/weight-loss/?utm_source=plussidez&utm_medium=partnership&utm_campaign=comms_yt&utm_content=45497&utm_term=55
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GLP-1 Stopped Working? What’s Really Happening with Dr. Spencer Nadolsky,

While Kim is on bereavement leave, we’re replaying one of our most important conversations. Thank you for continuing to listen and support the show during this time.

We’re bringing this episode back because our audience keeps growing, and many of you may be in a different stage of your journey now. Maybe you’ve hit a plateau, gone months without losing weight, or started wondering, “Is my GLP-1 even working anymore?”

In this replay, we’re joined by Dr. Spencer Nadolsky, obesity specialist and founder of Vineyard, to break down what’s really happening when progress slows or stops.

In this episode, we cover:

• Why your GLP-1 may feel like it “stopped working” and what’s actually happening
• The truth about plateaus, stalls, and going months without weight loss
• Why food noise can come back and what that means
• How dose, metabolic adaptation, and expectations play into progress
• What to know about weight regain and whether this is a “forever” medication
• How to think about goal weight and long-term strategy
• The role of exercise and metabolism as your body changes
• The emotional side, including feeling flat or disconnected

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#Mounjaro #MounjaroJourney #Ozempic #Semaglutide #tirzepatide  #GLP1 #Obesity #zepbound #wegovy

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Listener Note:
**IMPORTANT** This episode includes discussions of trauma, family dynamics, narcissistic relationships, and eating disorders. Please take care while listening and choose a time and setting that feels right for you.

Over the past three years, a clear pattern has emerged. Many patients trace their struggles with weight back to childhood, shaped by family dynamics, support, and the ripple effects of diet culture.

GLP-1 medications are changing obesity treatment by addressing biology, and obesity is largely genetic. It is also multifactorial. Factors like stress, trauma, and early environments do not cause obesity on their own, but they can make it harder to manage. Yet this part of the conversation is often missing. While attention is placed on medication or diet and exercise, the impact of lived experience is rarely addressed.

In this episode, we cover:

•  How childhood and family dynamics shape long-term patterns 
•  The impact of stress, trauma, and narcissistic relationships on weight management 
•  Boundaries, including low contact and no contact, as part of healing 
•  Why lived experience matters in obesity conversations 

This episode is led by co-host and producer Kat Carter, who brings both expertise and personal perspective to a conversation that is often overlooked.

Guest

This episode features insights from Dr. Sherrie Campbell, a licensed psychologist with over two decades of experience specializing in trauma, family dynamics, and helping people set boundaries with toxic relationships.

Learn more at: https://drsherriecampbell.com/

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#Mounjaro #MounjaroJourney #Ozempic #Semaglutide #tirzepatide  #GLP1 #Obesity #zepbound #wegovy #ObesityCare #PatientAdvocate #GLP1Community #RealGLP1Stories

Find Your US Representatives 

https://www.usa.gov/elected-officials 

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New Sponsor for GLP-1 appeals is Honest Care!

Ro - Telehealth for GLP1 Weight Management

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With more people starting GLP-1s like Wegovy and hearing about newer options like Orforglipron, we’re bringing back one of our most important early episodes.

This is a repost of Season 1, Episode 5, titled "Fast and Lazy, Debunking Stereotypes," created to help you understand what these medications actually do and why obesity is not a lack of willpower.

In this episode with bariatric surgeon Daniel Rosen, we cover:

• How GLP-1 medications actually work in the body
• Is it just appetite suppression or something more?
• Are GLP-1s the same as bariatric surgery? Do they work the same way?
• Why diets fail and why this isn’t about “lazy” or lack of discipline
• What “food noise” is and why it matters
• Are GLP-1s approved for kids and should they be?
• Why obesity is a chronic disease, not a personal failure

If you’re new to GLP-1s or trying to make sense of all the noise, this is where to start.
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#Mounjaro #MounjaroJourney #Ozempic #Semaglutide #tirzepatide  #GLP1 #Obesity #zepbound #wegovy

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Kim Carlos, Executive Producer 

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 New Sponsor - Honest Care to Appeal GLP-1 Insurance Denials

Ro - Telehealth for GLP1 Weight Management

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Do you actually need to exercise on GLP-1 to lose weight… or does it just help? In this episode, we talk with Jamie Selzer, who lost over 300 pounds on a GLP-1 and went on to become a personal trainer and TikTok creator helping others navigate obesity and fitness.

This is a real conversation about what changed, what mattered, and what didn’t.

We cover:
• Do you need exercise for GLP-1 weight loss
• When and how to start moving during your journey
• Strength training vs cardio on GLP-1
• Building muscle after major weight loss
• Letting go of all-or-nothing fitness thinking

From 300+ pounds down to trainer, Jamie shares what actually works in the real world and how to build a sustainable relationship with movement.

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#Mounjaro #MounjaroJourney #Ozempic #Semaglutide #tirzepatide  #GLP1 #Obesity #zepbound #wegovy #retatrutide

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Kim Carlos, Executive Producer 

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Resources for the Community:

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Find Your US Representatives 

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This episode is dedicated to my magical sister, Jessy Cole, who passed away recently just why of her 39th birthday. She was an artist and writer, and she created even on the hard days. This was set to record soon after her passing, but my sister was very proud of me for doing this podcast to help others and challenge the status quo. 

It’s not at my best work, for obvious reasons m, but I felt I wanted to honor her strength by creating even on the hard days. Thank you for your support. I love you. 

In this roundtable, Kim Carlos and Kat Carter sit down with board-certified obesity medicine physician Dr. Matthea Rentea to discuss three movements shaping the conversation around obesity: the GLP-1 movement, body positivity, and the no-lose movement.

All three have lived with obesity and have tried diet, exercise, and different treatments. They share what has worked, what has not, and why GLP-1 medications are changing what sustainable care can look like.

This episode also defines each movement:
•Body Positivity: Focused on dignity, inclusion, and ending weight stigma
•No-Lose Movement: Questions weight loss as a goal and pushes back on diet culture
•GLP-1 Movement: Treats obesity as a chronic metabolic disease with medical support

The conversation explores where these movements overlap, including reducing stigma and improving understanding of obesity, and where differences remain around weight loss, medication, and how health is defined.

At the center is a bigger question: can these movements work together to better support people living with obesity and change the world? More conversations to come. 

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#Mounjaro #MounjaroJourney #Ozempic #Semaglutide #tirzepatide  #GLP1 #Obesity #zepbound #wegovy #ObesityCare #PatientAdvocate #GLP1Community #RealGLP1Stories

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Kim Carlos, Executive Producer 

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Kat Carter,  Producer 

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Resources for the Community:

___________________________________________________________________

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Find Your US Representatives 

https://www.usa.gov/elected-officials ______________________________________________________________________

This isn’t medical advice — always talk to your doctor before making any health decisions

In this episode of The Plus SideZ, we break down the latest GLP-1 news and what it actually means in real life.

We’re joined by Dave (Man on Mounjaro), who shares his firsthand experience coming off a GLP-1 after years on treatment, while we also unpack emerging research and what’s coming next in this space.

This conversation covers both data and lived experience, including:

• What new studies say about stopping GLP-1 medications
 • Why benefits may reverse after discontinuation
 • Real-world weight regain, hunger, and metabolic changes
 • Mental health and brain-related effects tied to these medications
 • The difference between GLP-1 and GIP and why it matters
 • New and emerging medications being studied for neurological and metabolic conditions
 • Where treatment may be headed next beyond weight loss

This episode connects the dots between science, patient experience, and the future of obesity treatment so you can better understand what’s happening now and what may be coming next.

Whether you’re on a GLP-1, considering one, or thinking about long-term use, this is a must-listen conversation.

Guest Host:  Dave Knapp @OnThePenPodcast

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#Mounjaro #MounjaroJourney #Ozempic #Semaglutide #tirzepatide  #GLP1 #Obesity #zepbound #wegovy #ObesityCare #PatientAdvocate #GLP1Community #RealGLP1Stories

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Support the show

Kim Carlos, Executive Producer 

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Kat Carter,  Producer 

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Resources for the Community:

___________________________________________________________________

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Find Your US Representatives 

https://www.usa.gov/elected-officials ______________________________________________________________________

This isn’t medical advice — always talk to your doctor before making any health decisions.

What happens when one half of a couple goes on a GLP-1, and the other half hops in for the ride?

In this episode, we’re chatting with another couple doing it together, treating their obesity with a GLP-1. You could call them a “GLP-1 household." Libby and Greg, both patients of Ro, talk to us about life going from "Food-Obsessed Couple" to "People Who Actually Have Leftovers."

We’re getting into the nitty-gritty of the "Dual-GLP-1" lifestyle, including:

"Coming Out" Story: How to tell your spouse you’re starting a GLP-1.

The Relationship "Side Effects": Dealing with the "comparison trap," supporting each other through the side effects, and how a boost in confidence changes relationship dynamics. 

Household Changes: From challenging the way they talk about "good vs. bad" food to showing up for their kids without the food noise.

This episode is a raw, funny, and medically-backed look at how a simple injection can create a massive ripple effect in a marriage

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#Mounjaro #MounjaroJourney #Ozempic #Semaglutide #tirzepatide  #GLP1 #Obesity #zepbound #wegovy #ObesityCare #PatientAdvocate #GLP1Community #RealGLP1Stories

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Plus SideZ Family,

My (Kim) sister Jessy has passed away just shy of her 39th birthday. I tell you about her in this clip. It’s not scripted and far from perfect sound. Obviously, my family and I are grieving deeply right now. And many people have asked how they can help. 

I need to take a little break from the podcast, but we will play some greatest hits & Kat may do an episode or two by herself. During this time, I ask for your continued support to download episodes, leave reviews (desperately need more), comment, share, etc. so our podcast shows up in the algorithm & will be found by people who are lost, sick, and looking for answers & community like you once were. 

Thank you for helping my life have bigger meaning & for your support while I’m grieving with my family. I love you. 

Send us Fan Mail!

Support the show

Kim Carlos, Executive Producer 

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Kat Carter,  Producer 

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