In this part 2 episode, we dive into the pathology and symptoms of Babesiosis, exploring how the Babesia parasite infects red blood cells and evades the immune system. We discuss various labs and biomarkers to look out for. We then address various treatment protocols featuring anti-malarials including herbal supplements such as artemisinin and cryptolepis, and proteolytic enzymes like lumbrokinase and nattokinase. Additionally, we cover the use of methylene blue and its impact on Babesia parasites.

Topics:

1. Introduction

- Brief overview of Babesiosis and previous discussion

- Overview of Babesia infection and its impact on red blood cells (RBCs)

2. Pathology of Babesiosis

- Infection and multiplication within RBCs

- Mechanisms of immune evasion

- Expression of specific proteins on RBC surface

- Adherence to capillary endothelial cells

- Avoidance of spleen clearance

- Antigenic variation and immune system evasion

3. Symptoms of Babesiosis

- Air hunger

- High fever

- Severe fatigue

- Muscle and joint pain

- Persistent headaches

- Jaundice

- Dark urine

- Organ failure (in severe cases)

4. Labs and Markers for Babesiosis

- Hematological markers

- Hemolytic anemia

- Thrombocytopenia

- Leukopenia

- Hemoglobinuria

- Hyperbilirubinemia

- Elevated LDH levels

- Reticulocytosis

- Other markers

- High C4a levels

- Low CD57 count

5. Protocols

- Importance of medical supervision and potential Herxheimer reaction

- Overview of treatment approaches

6. Anti-Malarial Protocols for Babesiosis

- Prescription Medications

- Mepron (Atovaquone), Mechanism of action: inhibition of mitochondrial electron transport chain.

- Azithromycin, Mechanism of action: blocking protein synthesis.

- Herbal Approaches for Babesiosis

- Artemisinin: Derived from sweet wormwood plant. Mechanism of action: production of reactive oxygen species (ROS).

- Cryptolepis: Bioactive compound is Cryptolepine, Mechanism of action: disruption of DNA synthesis.

7. Proteolytic Enzymes

- Lumbrokinase

- Nattokinase

8. Methylene Blue

- Synthetic dye

- Mechanism of action: disrupting mitochondrial function and generating ROS within Babesia

- Administration methods and effects

9. Conclusion

- Recap of supplements and treatments discussed

- Emphasis on individualized treatment plans, bioindividuality, and working with a medical physician

Thank you to our episode sponsor: ⁠Liver Medic⁠

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In this episode, we explore the intricacies of Babesia and Babesiosis, exploring how this protozoan parasite infects red blood cells and evades the immune system. We discuss the various pathological effects of the infection, including impaired blood flow, tissue ischemia, and multi-organ dysfunction syndrome. Additionally, we cover common symptoms, relevant bloodwork indicators, and an overview of anti-malarial herbs/supplements and other strategies often employed in cases of Babesia.

Topics:

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⁠https://x.com/livermedic⁠

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We are honored to be joined by Brendan Gaughran. Brendan Gaughran, the founder of Liver Medic, holds a degree in Molecular Biology from the University of Connecticut and an MBA from Bentley University. He is an expert in gut health, liver health, the endocrine system, adrenal fatigue, and optimal diets. Brendan frequently conducts health lectures for both physicians and the general public. Through Liver Medic, he manufactures proprietary liver and digestive supplements, leveraging his extensive research and knowledge.

Topics:

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Brendan's YouTube Channel

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In today's episode, we explore the connection between biotoxin illness (including Lyme disease) and dysautonomia, as well as nervous system dysfunction, in general. And, we outline strategies for supporting nervous system repair through addressing the root cause and using strategic phospholipid support.

Topics:

1. Introduction to the Nervous System

- Overview

- Central Nervous System (CNS): Brain and Spinal Cord

- Peripheral Nervous System (PNS): Connection to CNS, Transmission of Sensory Information and Motor Commands, Involuntary Functions

2. Divisions of the Peripheral Nervous System (PNS)

- Somatic Nervous System (SNS): Voluntary Control, Sensory (Afferent) Neurons (Function and Examples), Motor (Efferent) Neurons (Function and Examples)

- Autonomic Nervous System (ANS): Involuntary Physiological Functions, Maintenance of Homeostasis

3. Subdivisions of the Autonomic Nervous System (ANS)

- Sympathetic Nervous System (SNS): 'Fight or Flight' Response

- Parasympathetic Nervous System (PNS): 'Rest and Digest' Response

- Enteric Nervous System (ENS): Regulation of Gastrointestinal (GI) Tract

4. Dysfunction of the Autonomic Nervous System: Dysautonomia

- Definition and Symptoms

- POTS

- Some Causes: Infections (e.g., Lyme Disease), Biotoxin Illness, Other Contributing Factors

5. Mechanisms of Nerve Damage in Lyme Disease

- Direct Bacterial Invasion

- Inflammation and Cytokine Storm

- Out of Control Autoimmune Reactions

6. Impact of Lyme Disease on the Nervous System

- Cardiac Vagal Tone Impairment

- Dendritic Pruning

- Demyelination

- Small-Fiber Neuropathy: Symptoms, Improvement with Antimicrobial Treatments

7. Supporting Nervous System Repair

- Phospholipid Support: Phosphatidylcholines and Cell Membrane Integrity, Repairing Myelin Sheath, Recovery and Regrowth of Dendritic Structures

- Benefits for CNS and PNS

- Importance of Addressing Root Cause (Infection) and Repair Strategies

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7.1 Adrenal Cortex

7.2 Adrenal Medulla

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In today's episode, we explore the role of Thymosin Alpha 1 Peptide in modulating the immune system, specifically its effects on Th1 and Th2 responses. The episode further delves into the mechanisms by which Borrelia burgdorferi evades immune detection and offers strategies to enhance immune effectiveness against this stealthy pathogen. Additionally, we discuss the broader implications of immune modulation in chronic Lyme disease and mold exposures.

Topics:

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In this episode, we undertake a detailed examination of the diverse mechanisms of action underlying various binders employed in detoxification protocols, with a particular focus on their application in biotoxin illnesses such as Lyme disease. We dissect the differential efficacy of bile acid sequestrants like cholestyramine versus natural binders such as activated charcoal and zeolite, elucidating their distinct modes of action in toxin adsorption and excretion pathways. Moreover, we elucidate the intricate interplay between chemical charges of binders and biotoxins like lipopolysaccharides (LPS), shedding light on the complexities of binder selection for optimal detoxification outcomes.

Topics:

1. Introduction to Binders

- Definition of binders

- Purpose in detoxification

- Application in Lyme disease treatment

2. Mechanisms of Action

- Bile Acid Sequestrants vs. Natural Binders

- Bile Acid Sequestrants:

- Function of cholestyramine

- Interaction with bile acids

- Impact on toxin excretion

- Natural Binders:

- Adsorption mechanism

- Broad-spectrum binding capacity

3. Chemical Charge Considerations

- Impact of charge on binding efficacy

- Interaction with biotoxins like lipopolysaccharides (LPS) which are negatively charged

- Paper published showing how activated charcoal (-) can help bind LPS (-), indicating that charge doesn't totally eliminate its binding ability

4. Selection of Binders

- Bile Acid Sequestrants:

- Cholestyramine

- Okra powder (Beets, Carrots...)

- Natural Binders:

- Activated Charcoal

- Bentonite Clay

- Zeolite

- Chlorella

- Cilantro

- Pectin

- Importance of using a spectrum of binders

5. Timing and Compatibility

- Considerations for simultaneous use of different binders

- Importance of timing in binder intake

6. Supporting Detoxification Process

- Promotion of bile flow: ox bile + bitters

- Support for liver detoxification

- Supplements for liver support

7. Conclusion and Recap

- Summary of binder types and their roles

- Importance of binders in biotoxin illness treatment

- Recognition of compromised immune system's role in toxin clearance (HLA genes)

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Today I am addressing the "early steps" in combatting Lyme or mold. So, I begin by diving into the phenomenon of Herxheimer reactions, elucidating its occurrence following antimicrobial therapy initiation for Lyme disease. Through this, I explore the intricate interplay between microbial factors, such as the release of endotoxins (LPS), and host immune responses, leading to a cascade of inflammatory reactions. Moreover, I provide practical strategies that may help mitigate Herxheimer reactions, including gradual dose titration, anti-inflammatory supplementation, binders, baths, and support for the body's natural detoxification pathways (liver, lymph, kidneys, and more).

Topics:

1. Understanding Herx Reactions

- Definition and Manifestation

- General Overview of Symptoms

2. Underlying Mechanisms of Herx Reactions

- Host Immune Responses

- Microbial Factors

3. Microbial Factors in Herx Reactions

- Release of Endotoxins

- Role of Gram-Negative Bacteria

- Impact on Immune Response (LPS)

- Example: Lyme Disease as a Model

4. Inflammatory Response

- Pro-inflammatory Cytokines

- TNF-α, IL-6, IL-1β

- Immune Response Propagation

- Vasodilation

- Vascular Permeability

- Immune Cell Recruitment

5. Acute-Phase Response

- Ex: Induction of Fever via the Hypothalamus

- Systemic Manifestations and Other Symptoms

6. Phagocytic Immune Cells

- Macrophages

- Antigen Presentation

- Cytokine Release

- Neutrophils

- Role in Early Innate Immune Response

7. Transition to Adaptive Immune Response

- Specificity

- Role of T Cells and B Cells

- Immunological Memory

8. Implications of Inefficient Adaptive Immune Response Activation

- Chronic Infection and Inflammation

- Cause: Disruption in Antigen Presentation

9. Biotoxin Illness and Genetic Factors

- Role of HLA Genes

- Chronic Inflammatory Response Syndrome

10. Mitigating Herx Reactions

- Slow Titration of Antimicrobial Therapy

- Reducing Inflammation: Omega-3s, SPMs, Curcumin, Quercetin, Ginger, Boswellia, etc.

- Supporting Clearance Pathways

- Liver, Lymph, Kidneys

- Hydration and Proper Elimination

- Epsom Salt Baths

- Use of Binders: Activated Charcoal, Chlorella, Cholestyramine etc.

Thank you to our episode sponsor:

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Today, we are delighted to introduce Justin Bosley, the President and Head Chemist at Evexia Science.

Raised amidst health challenges that confounded traditional medical solutions, Justin embarked on a lifelong quest for remedies. Fueled by an innate curiosity and a passion for health and science, he pursued a degree in nutritional science at Brigham Young University. Subsequently, driven by an unyielding commitment to innovation, he augmented his expertise with another degree in chemistry, specializing in biochemistry.

Justin's journey into product formulation initially stemmed from personal necessity—unable to find suitable solutions in the market, he took matters into his own hands. What began as a personal endeavor soon evolved into a shared passion as his creations garnered acclaim among friends and family. Encouraged by their positive reception and fueled by a burgeoning demand, Justin made the courageous decision to pivot from a conventional career path, dedicating himself fully to Evexia Science.

Topics:

1. Justin's story and motivation for Evexia Health

2. What is plaque?

- Formation and composition of plaque

- Transformation into calculus or tartar

- Microbial-rich environment

3. Negative consequences of plaque

- Greater risk for diabetes

- Potential link to dementia

- Impact on brain health due to tooth infections and neuroinflammation

4. Effects of acids and bases on teeth

- Baking soda's impact on plaque, gingivitis, and gum bleeding

- Acid neutralization

- Hidden sources of acids in one's diet

- Acid-producing bacteria

5. Strategic Ingredient breakdown of The Honest Tooth

- Baking soda - abrasive

- Monolaurin

- Essential oils

- Xylitol

6. Common misconceptions about oral care

7. Tooth powder vs. paste

8. Electric toothbrush vs. regular

The Honest Tooth - Evexia Health

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We are diving into the intricate processes of liver detoxification, from the anatomy of the liver and its blood flow circuitry to the phases of detoxification involving enzymes and conjugation reactions. I highlight the importance of supporting optimal liver function to prevent toxin accumulation and associated symptoms, underscoring the significance of various compounds and peptides, such as Dihydromyricetin (DHM), N-acetylcysteine (NAC), and peptide bioregulators like Svetinorm and Ovagen, in aiding liver health and detoxification processes.

Topics:

1. Introduction to Liver Detoxification

- Importance of supporting the liver in processing and eliminating toxins

- Symptoms of liver congestion: digestive issues, bloating, dark under eye circles, edema, skin conditions, etc.

2. Liver Biology and Processes

- Anatomy of the liver: lobes, lobules, ducts

- Blood flow circuitry within the liver

- Hepatic Artery

- Portal Vein

- Sinusoids

- Hepatic Vein

- Exchange of molecules between sinusoids and hepatocytes

3. Phases of Liver Detoxification

- Phase 1 metabolism: Cytochrome P450 enzymes

- Phase 2 metabolism: Conjugation reactions

- Glucuronidation

- Sulfation

- Glutathione conjugation

- Amino acid conjugation

- Acetylation reactions

- Methylation reactions

4. Elimination of Toxins

- Movement of conjugates back into bloodstream

- Excretion into bile ducts

- Role of bile in digestion and excretion

5. Implications of Impaired Detoxification

- Accumulation of toxins leading to various symptoms

- Hormonal imbalance and its effects

6. Introduction to Supporting Compounds and Peptides

- Overview of newer compounds and peptides for liver support

- Dihydromyricetin (DHM)

- N-acetylcysteine (NAC)

- Calcium D-glucarate

- Globe artichoke

- Milk thistle

- Selenium

- Glycine

- Taurine

7. Peptide Bioregulators for Liver Support

- Svetinorm

- Ovagen

- Molecular composition and interaction with DNA

- More trials and research are welcomed in this field

Thank you to our episode sponsors:

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