In this episode, we explore the role of Vitamin D in brain health, focusing on how its active form, calcitriol (1,25-dihydroxyvitamin D3), influences cognitive function and neuroprotection. We’ll discuss the synthesis of Vitamin D, its conversion into its active form, and its ability to cross the blood-brain barrier to exert effects on neurons and glial cells. Additionally, we will highlight how calcitriol regulates gene expression through Vitamin D Response Elements (VDREs), impacting inflammation, antioxidant defense, and neurotrophic support. Finally, we touch on the symptoms of low Vitamin D and the link to cognitive decline.

Topics:

1. Introduction to Vitamin D and the Brain

- Forms of Vitamin D, synthesis, conversion/activation, and its role in the brain

2. Vitamin D

- Vitamin D2 (ergocalciferol), plant-based sources like mushrooms

- Vitamin D3 (cholecalciferol), UVB radiation, animal-based foods

- Inactive forms

3. Synthesis and Conversion of Vitamin D3

- Synthesis in the skin: 7-dehydrocholesterol converts to pre-vitamin D3

- Conversion in the liver: 25-hydroxylase converts D3 to 25-hydroxyvitamin D (calcidiol)

- Final activation in the kidneys: 1-alpha-hydroxylase converts calcidiol to 1,25-dihydroxycholecalciferol (calcitriol), the active form

4. Calcitriol and the Blood-Brain Barrier

- Calcitriol’s lipophilic nature, crossing the BBB

- The structure and function of the blood-brain barrier

- How calcitriol diffuses across the BBB and reaches brain cells

5. Calcitriol's Role in the Brain

- Interaction with Vitamin D receptors (VDRs) in neurons and glial cells

- VDRs in key brain regions: hippocampus, prefrontal cortex, cerebellum, basal ganglia

- Binding of calcitriol to VDRs, conformational change, and formation of the VDR-RXR complex

6. Gene Regulation via Vitamin D Response Elements (VDREs)

- Overview of VDREs in promoter regions of genes

- Role of calcitriol in activating or repressing gene transcription

7. Impact on Inflammatory Responses

- VDREs in anti-inflammatory genes promote IL-10 expression

- Calcitriol’s role in reducing pro-inflammatory cytokines like IL-6 and TNF-alpha

8. Neurotrophic Factors

- VDREs’ role in regulating genes that promote BDNF

- BDNF’s impact on neuron survival, growth, and synaptic connectivity

9. Antioxidant Enzymes

- VDREs influence the expression of glutathione peroxidase and superoxide dismutase (SOD)

- The role of these enzymes in defending neurons from oxidative stress

10. Brain Regions & Calcitriol

- Hippocampus: Learning, memory, neurogenesis, synaptic plasticity

- Prefrontal Cortex: Executive functions, mood regulation

- Cerebellum: Motor control, cognitive processing, calcium homeostasis

- Basal Ganglia: Movement regulation, protection of dopaminergic neurons

- Amygdala: Emotion processing, fear, anxiety, stress response

11. Interconnection of Brain Regions

- How Vitamin D’s effects on neurotransmitter regulation, anti-inflammatory action, and calcium homeostasis create a global protective effect.

12. Conclusion

- Recap of calcitriol’s cellular mechanisms and neuroprotective effects

- Symptoms of low Vitamin D

Thank you to our episode sponsor:

1. Check out ⁠⁠⁠⁠⁠⁠⁠⁠⁠Daily Nouri⁠⁠⁠⁠⁠⁠⁠⁠⁠ and use code ⁠⁠⁠⁠⁠⁠⁠⁠⁠CHLOE20⁠⁠⁠⁠⁠⁠⁠⁠⁠ for 20% off your order.

Thanks for tuning in!

Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠"

Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Follow Chloe on TikTok @chloe_c_porter

Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

We are honored to be joined by Carri Norton and Ron Butterworth, the Co-Founders of the Sparkle Revolution App. Carri is an accomplished professional in software application development, with experience across various industries such as educational software, solar monitoring, energy management, and HVAC digital solutions. Starting her career as a software developer, she progressed into management and leadership roles, contributing to both startups and Fortune 500 companies. Her passion lies in creating user-centric software solutions that enhance customer experiences and make lives better. Ron’s professional career has been that of a hardware design engineer. He has had the opportunity to work on projects based in education, solar energy, agriculture, and augmented reality, to name a few. Together they were thrilled to combine their expertise with personal passions and launch Sparkle Revolution.

Topics:

1. Motivation to Create the App / Personal Journeys for Ron and Carri

- Inspiration behind the app

- Personal stories of Ron and Carri

- Introduction to the app and its 4 "foundations"

2. How the App’s Foundations Relate to Health

- Overview of the 4 foundations

- Impact of these foundations on mental, emotional, and physical health

3. Science and Studies on Mindfulness and Gratitude

- Research on mindfulness practices

- Scientific evidence on the benefits of gratitude

4. Examples of Mindfulness Exercises

- Simple exercises for beginners

- Techniques used to enhance daily mindfulness

5. Manifestation and Visualization Techniques

- How manifestation works on a psychological level

- Rewiring the brain to embrace future opportunities

6. Personal Examples of Manifestation in Action

- Stories from Ron and Carri’s lives

- Real-world outcomes from practicing manifestation

7. Strategies for Integrating Mindfulness and Building Habits

- Daily habits to foster mindfulness

- Tips for sustainable habit formation

8. Overview of the Sparkle Revolution App

- How the app works

- Features and functionality

- Where to download the app

9. Social Handles, Website, and Other Resources

- Social media platforms

- Official website and contact info

- Additional tools or resources for further exploration

To learn more and get the app, check out www.sparklerevolution.com

Search for Sparkle Revolution on the Apple or Android stores. 

Visit them on social media @SparkleRevolutionApp

Take advantage of an introductory offer! Use code CHLOE60 to get 60% off an annual subscription.

Studies & Articles Mentioned:

In this episode, we dive into the role of microglial cells, the brain’s resident immune defenders, and how their chronic activation at the cellular level contributes to neurodegeneration. We'll explore the cellular mechanisms behind microglial activation, including the involvement of P2Y12 receptors and the release of pro-inflammatory cytokines like IL-1β and TNF-α. Additionally, we'll discuss how everyday environmental toxins and stressors can trigger long-term microglial activity, potentially increasing the risk of conditions like Alzheimer's.

Topics:

1. Introduction

- Overview: Microglia and neurodegeneration.

- Environmental toxins affecting microglia.

2. Brain and Microglial Overview

- Brain has neurons and glial cells.

- Microglia are the brain's immune cells.

- Roles: Immune defense, synaptic pruning, neuroprotection.

3. Microglial Immune Function

- Constantly monitor for infection and damage.

- Activated microglia perform phagocytosis.

- Clear debris and maintain brain health.

4. Cellular Mechanisms of Activation

- P2Y12 receptors respond to ATP/ADP.

- Microglia shift from resting to activated.

- Activated microglia are highly phagocytic.

5. Role in Synaptic Pruning

- Microglia help in synaptic pruning.

- Remove weak synapses for efficient brain circuits.

6. Microglia in Neurodegeneration

- Chronic activation leads to inflammation.

- Release of cytokines like IL-1β, TNF-α, IL-6.

- Contributes to Alzheimer's, Parkinson's.

- MHC molecules

7. Environmental Toxins and Activation

- Mycotoxins cross BBB and activate microglia

- Heavy metals like lead, aluminum affect neurons

- Pesticides/herbicides linked to Parkinson’s risk

8. Other Factors Activating Microglia

- Industrial chemicals, BPA

- Artificial additives, alcohol

- Chronic stress

9. Conclusion

- Recap: Microglial functions and overactivation.

- Lifestyle factors influence microglial health.

Thank you to our episode sponsors:

1. Check out ⁠⁠⁠⁠⁠⁠⁠Daily Nouri⁠⁠⁠⁠⁠⁠⁠ and use code ⁠⁠⁠⁠⁠⁠⁠CHLOE20⁠⁠⁠⁠⁠⁠⁠ for 20% off your order.

2. Check out the TruAge ⁠Biological Age Test⁠ from ⁠TruMe Labs⁠.

Thanks for tuning in!

Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠"

Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Follow Chloe on TikTok @chloe_c_porter

Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

In this episode, we explore the critical role of Secretory IgA (sIgA) in maintaining intestinal health. We discuss how sIgA acts as a frontline immune defense, preventing pathogens from adhering to the gut epithelium and aiding in controlling microbial populations. Additionally, we dive into the implications of low and high sIgA levels - as indicated in a stool test, how sIgA levels relate to dysbiosis and Candida overgrowth, addressing underlying root causes, and tools for supporting healthy sIgA levels.

Topics:

1. Introduction to Secretory IgA and its Functions

- Overview of sIgA's role in mucosal immunity

- Importance of sIgA in maintaining the gut's lining integrity

- How sIgA regulates pathogenic microbes in the gut

2. Structure of the Gut Lining and Mucosal Layers

- The intestinal lumen and the protective mucus layer

- Layers of the intestinal wall: mucosa, submucosa, muscularis, and serosa

- The epithelium within the mucosa: epithelial cells including goblet cells

3. The Mucus Layer and Its Protective Function

- Composition of the mucus layer: mucins and other components

- How the mucus acts as both a physical and biochemical barrier

- Differences between the mucus layer in the small and large intestines

4. Secretory IgA: Location and Role in the Gut

- Where sIgA is found in the mucus layer

- Differences in sIgA concentration in the small vs. large intestine

- Interaction between sIgA and mucins to trap pathogens

5. Production and Secretion of Secretory IgA

- Plasma cells in the lamina propria and their role in sIgA production

- Transport of sIgA across the gut epithelium via the polymeric immunoglobulin receptor (pIgR)

- Secretory component (SC) and its role in protecting sIgA from degradation

6. Immune Functions of sIgA in the Gut

- Binding and neutralizing pathogens

- The process of immune exclusion

- The role of sIgA in preventing pathogen adherence to epithelial cells

7. Low and High sIgA Levels and Gut Conditions

- What low and high sIgA levels can indicate in a stool test

- Gut conditions associated with abnormal sIgA levels (e.g., dysbiosis, Candida overgrowth, infections)

- The impact of chronic stress and prolonged infections on sIgA levels

8. Root Causes for Low sIgA Levels

- Addressing root causes and underlying infections

- Lifestyle factors that support healthy sIgA levels

- Nutrients such as Vitamin A and Zinc for supporting sIgA production

9. Probiotics & More to Support sIgA

- Probiotics, prebiotics, and phages that enhance sIgA production

- Individual gut health needs

Thank you to our episode sponsors:

1. Check out ⁠⁠⁠⁠⁠⁠Daily Nouri⁠⁠⁠⁠⁠⁠ and use code ⁠⁠⁠⁠⁠⁠CHLOE20⁠⁠⁠⁠⁠⁠ for 20% off your order.

2. Check out the TruAge Biological Age Test from TruMe Labs.

Thanks for tuning in!

Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠"

Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Follow Chloe on TikTok @chloe_c_porter

Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

In this episode, we explore the critical roles of the enteric nervous system (ENS) and the vagus nerve in digestion and gut motility. We also examine how autonomic nervous system dysfunction can contribute to conditions such as Small Intestinal Bacterial Overgrowth (SIBO).

Topics:

1. Introduction to the Nervous System and Its Role in Digestion

- Overview of the enteric nervous system (ENS) and vagus nerve

- Focus on location, function, and associated dysfunctions

2. Overview of the Enteric Nervous System (ENS)

- ENS as one of the three divisions (Sympathetic, Parasympathetic, Enteric)

- Location and function overview

3. The Mucosa

- Structure and Function of the Mucosa

- Epithelium (cells such as enterocytes, goblet cells, enteroendocrine cells)

- Lamina propria (loose connective tissue, immune cells)

- Smooth muscle layer

4. The Submucosa

- Structure and Function of the Submucosa

- Thicker connective tissue providing support for blood vessels, lymphatics, and nerves

5. The Submucosal Plexus (Part of the ENS)

- Location and Functions of the Submucosal Plexus

- Regulation of digestive enzyme secretion, mucin production, and electrolyte balance

- Role in creating protective mucus barriers and controlling local blood flow

6. Mucus Secretion and Protection

- Role of Goblet Cells

- Secretion of mucins and formation of the protective mucus layer

7. Blood Flow Regulation by the Submucosal Plexus

- Role in adjusting blood supply during digestion

8. Neuronal Cells of the Submucosal Plexus

- Sensory Neurons: Detecting changes in the gut

- Interneurons: Processing and integrating sensory input

- Secretomotor Neurons

9. Communication Between Neurons and Epithelial Cells

- Chemical Signaling and Neurotransmitters

- ACh and Vasoactive Intestinal Peptide (VIP)

- Serotonin's role in activating sensory neurons and regulating secretion

10. Role of the Vagus Nerve in Digestive Regulation

- Vagus Nerve as Part of the ANS

- Regulation of digestive secretions, gut motility, and smooth muscle contractions

11. Small Intestinal Bacterial Overgrowth (SIBO)

- Connection Between Autonomic Nervous System Dysfunction and SIBO

- Reduced motility leading to bacterial overgrowth

- Impact on gut environment

- Root cause approach

Thanks for tuning in!

Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠"

Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Follow Chloe on TikTok @chloe_c_porter

Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

We are honored to be joined by Dr. Diana Driscoll. An authority on the autonomic nervous system, Dr. Diana Driscoll, Optometrist, FAAO, is a world-renowned expert on POTS (Postural Orthostatic Tachycardia Syndrome), and other “invisible” illnesses. As an author, speaker, inventor, and devoted researcher with five patents to date, she continues to push forward with dramatic shifts in the evaluation and treatment of these conditions. Dr. Driscoll's personal battle with POTS inspired a decade of self-funded groundbreaking research and innovative treatment. Now an authority on POTS, IIH, ME/CFS, the vagus nerve, dry eye disease, neurological gastroparesis, and brain health, she offers the compassion of a former patient, as well as strong science.

Topics:

1. Introduction and Personal Journey

- Discussion of Dr. Diana Driscoll's personal battle with POTS and how it led to her groundbreaking research.

2. Overview of POTS (Postural Orthostatic Tachycardia Syndrome)

- Diagnostic criteria and common symptoms.

- How POTS develops.

- The body systems affected by POTS and how they are impacted.

3. Inflammatory POTS

- Definition and introduction to "Inflammatory POTS"

4. Nervous System and the Vagus Nerve, Specifically

- Further exploration of the role of the nervous system in POTS.

- The impact of the vagus nerve on various body functions, including digestion and bowel movements.

- Understanding chronic dry eyes.

5. Supplementation and Solutions

- TJ Nutrition resources and supplements.

- Parasym Plus™ to support the vagus nerve and acetylcholine functions.

- Beta Balance™ NAC MAX™

Thanks for tuning in!

Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠"

Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Follow Chloe on TikTok @chloe_c_porter

Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

In today's episode, we dive into the molecular mechanisms underlying neuroinflammation, with a particular focus on how gut-derived endotoxins, such as lipopolysaccharides (LPS), perturb the blood-brain barrier (BBB) and propagate neuroinflammatory cascades. In more detail, we’ll discuss how intestinal dysbiosis and increased intestinal permeability can allow endotoxins such as LPS to enter systemic circulation and cross the blood-brain barrier (BBB), where they activate microglia via the TLR4 signaling pathway. We will explore symptoms including brain fog, memory impairment, mood disturbances, decreased concentration, and cognitive fatigue; as well as tools to support the gut-microbiota-brain axis.

Topics:

1. Introduction to Neuroinflammation

- Definition and general overview

- Key brain cells: neurons, glial cells, and endothelial cells

- Chronic neuroinflammation and microglial cells

2. Cellular Mechanisms of Neuroinflammation

- Role of microglia in detecting damage or infection

- Microglial activation through PRRs/TLRs

- Release of pro-inflammatory cytokines and reactive oxygen species (ROS)

- Impact on neurons and synaptic plasticity: memory and learning

3. Astrocytes in Neuroinflammation

- Astrocytes' contribution to the inflammatory response

4. Chronic Neuroinflammation and Brain Health

- Prolonged activation: oxidative stress, excitotoxicity, impaired synaptic function

- Impairment of synaptic plasticity and cognitive decline

- Mitochondrial dysfunction and cell death cascades

- Compromised blood-brain barrier integrity

5. Contributing Factors to Neuroinflammation

- Environmental toxins and pollutants, viral or bacterial infections, chronic sleep deprivation, and more

6. Intestinal Dysbiosis and Neuroinflammation

- Role of Gram-negative bacteria and LPS (lipopolysaccharides)

- Increased intestinal permeability and passage of LPS

- LPS transport: transcellular and paracellular pathways

- Impact on the blood-brain barrier (BBB)

7. LPS Activation of Microglia

- LPS binding to TLR4 on immune cells

- Microglial activation and cytokine release

- Cognitive impairments and neurodegenerative processes

8. Intestinal Hyperpermeability

- Bioindividual approaches: prebiotics, probiotics, polyphenols, bacteriophages

- Support for intestinal mucus secretions and sources of mucilage

- Butyrate

- Glutamine

9. Beneficial Gut Microbiome-Derived Metabolites and Brain Health

- Types of metabolites: SCFAs, tryptophan metabolites, polyphenol metabolites

- Role of butyrate in crossing the BBB and modulating brain function

- Influence on gene expression and synaptic plasticity

- Contribution to gut barrier integrity and protection against endotoxins

10. Conclusion

- Recap of neuroinflammation's impact on cognitive function + symptoms

Thank you to our episode sponsor:

1. Check out ⁠⁠⁠⁠⁠Daily Nouri⁠⁠⁠⁠⁠ and use code ⁠⁠⁠⁠⁠CHLOE20⁠⁠⁠⁠⁠ for 20% off your order.

Thanks for tuning in!

Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠"

Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Follow Chloe on TikTok @chloe_c_porter

Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

In this episode, we dive into how short-chain fatty acids (SCFAs), particularly butyrate, and tryptophan metabolites support the gut-immune axis by promoting regulatory T cell differentiation, strengthening the intestinal barrier, and enhancing antimicrobial defenses through IL-22 signaling. We break down how butyrate can improve immune tolerance as well as epithelial integrity, aiding in the prevention of chronic inflammatory responses. We also detail practical ways to support butyrate levels and aid in strengthening both the epithelial barrier and gut-immune axis.

Topics:

1. Introduction

- Overview of the role of SCFAs and tryptophan metabolites in supporting the gut-immune axis.

- Quick review of the location of immune cells in relation to the gut microbiota.

2. The Intestinal Barrier

- Structure of the intestinal wall and layers

- Focus on the mucosal layer, specifically epithelium and lamina propria.

3. The Lamina Propria

- Structural elements: fibroblasts, extracellular matrix (ECM), and myofibroblasts.

- Vascular components: endothelial cells, capillaries, and lymphatic vessels.

- Importance of the lamina propria as a hub for immune responses.

4. Immune Cells in the Lamina Propria

- T cells: Role of regulatory T cells (Tregs) in immune modulation.

- B cells: Production of IgA, class switching, and plasma cells.

- Dendritic cells: Sampling luminal antigens and initiating immune responses.

- Macrophages: Phagocytic activity, pro-inflammatory (M1) vs. anti-inflammatory (M2) states.

- Mast cells: Role in allergic responses, chronic inflammatory conditions, and MCAS.

5. Short-Chain Fatty Acids (SCFAs)

- Production of SCFAs (acetate, propionate, butyrate) by gut microbiota.

- Butyrate’s role in supporting regulatory T cell (Treg) differentiation and immune tolerance.

-Butyrate as fuel for epithelial cells and the production of tight junction proteins.

6. Mechanisms of Butyrate in Immune Modulation

- Impact on Tregs through FoxP3 expression.

- SCFA’s role in maintaining immune balance.

7. Butyrate and Epithelial Integrity

- Support for tight junction protein expression.

- Prevention of translocation of harmful microbes and antigens.

- Reduced systemic inflammation through a strengthened barrier.

8. Supporting Butyrate Production

- Sodium butyrate supplementation and microbiome optimization.

- Role of fiber, polyphenols, and probiotics.

9. Tryptophan Metabolites

- Overview of tryptophan metabolism by gut bacteria into indoles.

- Indoles’ role in promoting IL-22 production, contributing to antimicrobial defense and immune tolerance.

10. IL-22

- IL-22’s enhancement of antimicrobial peptides (AMPs) and mucin production.

- Case Study: Role of Lactobacillus strains in restoring IL-22 and helping to mitigate colitis.

11. Conclusion

- Recap of how SCFAs and tryptophan metabolites interact with the gut-immune axis.

- Importance of gut microbiome support for maintaining immune balance.

Thank you to our episode sponsor:

1. Check out ⁠⁠⁠⁠Daily Nouri⁠⁠⁠⁠ and use code ⁠⁠⁠⁠CHLOE20⁠⁠⁠⁠ for 20% off your order.

Thanks for tuning in!

Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠"

Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Follow Chloe on TikTok @chloe_c_porter

Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

In this episode, we explore the crucial role of the protective mucus layer in maintaining intestinal lining integrity, highlighting how it shields the epithelial cells from harmful substances and supports overall digestive function. We dive into the components and functions of mucins, goblet cells, and secretory IgA, explaining their contributions to gut immunity and barrier integrity. Additionally, we discuss strategies for supporting mucus production centered around butyrate, N-acetyl glucosamine, and plant-derived mucilage.

Topics:

1. Introduction: Overview of the Gastrointestinal Mucus Layer

- Importance of the mucus secretions in forming a protective layer

- Brief review of the gastrointestinal lining and its structure

2. The Mucosal Layer and Its Components

- The mucus layer on the epithelial cells of the mucosa

- Four main layers of the intestinal wall, focusing on the mucosa

- Epithelium: absorptive enterocytes and mucus-secreting goblet cells

- Lamina propria: connective tissue rich in immune cells, blood vessels, and lymphatics

- Smooth muscle aiding in subtle movements

- Submucosa: thicker connective tissue layer with blood vessels, nerves, and lymphatics

3. Dual Function of the Mucus Layer

- Physical barrier preventing pathogens and toxins from reaching epithelial cells

- Biochemical barrier housing antimicrobial peptides and immunoglobulins

4. Goblet Cells and Their Role in Mucin Production

- Goblet cells: specialized epithelial cells producing mucins

- Distribution of goblet cells from small to large intestine

- Importance of goblet cells in maintaining the mucus barrier

5. Mucins: Structure and Glycosylation

- Glycosylation and its role in mucus properties and host-microbiota interactions

- Commensal bacteria and their interactions with mucins (e.g., Bacteroides and Akkermansia muciniphila)

6. The Importance of Controlled Mucin Degradation

- Mutualistic relationship between mucin-degrading bacteria and the host

- Risks of dysregulated mucin degradation, leading to dysbiosis and leaky gut

7. Secretory IgA and Its Role in Gut Immunity

- Overview of secretory IgA (sIgA) and its production

- sIgA’s mechanism of neutralizing pathogens "without inflammation"

- Immune exclusion as a defense mechanism to maintain gut barrier integrity

8. Recap: The Dynamic Nature of the Mucus Layer

- Continuous renewal of the mucus layer and the role of goblet cells and plasma cells

- Importance of regular mucus turnover for maintaining a healthy gut barrier

9. Supporting Gastrointestinal Mucus Production

- Short-chain fatty acids (SCFAs) and their role in stimulating mucus production

- Butyrate and its effects on goblet cells and epithelial repair

- N-Acetyl Glucosamine (NAG) as a supplement to support mucin glycosylation

10. Supporting the Intestinal Lining After Dysbiosis or Increased Permeability

- Mucilage and its role in coating and soothing mucosal surfaces

- Plant-derived mucilage from slippery elm and marshmallow root

- Physical protection provided by mucilage

- Soothing effects on inflamed tissues and promoting smooth digestion

Thank you to our episode sponsor:

1. Check out ⁠⁠⁠Daily Nouri⁠⁠⁠ and use code ⁠⁠⁠CHLOE20⁠⁠⁠ for 20% off your order.

Thanks for tuning in!

Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠"

Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Follow Chloe on TikTok @chloe_c_porter

Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

In this episode, we explore the neuroanatomical and molecular mechanisms underlying sleep regulation, focusing on the interplay between the suprachiasmatic nucleus, brain stem, and pineal gland in maintaining circadian rhythms. We dive into the biochemical pathways involving neurotransmitters such as GABA and hormones like melatonin, elucidating their synthesis and role in sleep-wake transitions. Further, the discussion extends to practical strategies, emphasizing the influence of light exposure on melatonin production and the potential benefits of specific amino acid supplementation in supporting sleep quality. Additionally, we address the impact of chronic inflammation and other root causes of sleep disturbances, exploring how systemic health issues can disrupt sleep.

Topics:

1. Introduction to Sleep Neuroanatomy

- Overview of key brain structures involved in sleep regulation

- Emphasis on the hypothalamus, brain stem, thalamus,

2. Deep Dive into Key Brain Structures

- Hypothalamus

- Detailed role of the suprachiasmatic nucleus (SCN) in circadian rhythm regulation

- Connection between SCN, light perception, and neuronal control

- Brain Stem

- Description of sleep-wake transitions mediated by the midbrain, pons, and medulla

- Mechanisms of GABA production and its impact on inhibitory neurotransmission

- Thalamus

- Functions as a sensory relay

- Pineal Gland

- Regulation of melatonin synthesis, influenced by light exposure and SCN signaling

- Basal Forebrain

- Neuronal mechanisms promoting alertness and facilitating sleep onset

- Role of adenosine accumulation in sleep pressure and its neurochemical effects

3. Mechanisms of Sleep Regulation

- Exploration of the circadian rhythm's molecular underpinnings involving CLOCK and BMAL1 genes

- Feedback loops involving period and cryptochrome proteins, detailing their synthesis and degradation within the SCN

- Hormonal regulation by the SCN through cortisol and melatonin

4. Strategies to Support Sleep Quality

- Importance of synchronizing light exposure with natural environmental cycles

- Supplementation strategies based on literature:

- GABA and L-theanine supplementation supporting inhibitory signaling

- L-tryptophan may support serotonin and melatonin synthesis

5. Addressing Underlying Root Causes and Sources of Chronic Inflammation Contributing to Poor Sleep

- Role of neuroinflammation and gut dysbiosis in sleep disruption

- Discussion on neurotransmitters synthesized in the gut

- Hormonal impacts

Thank you to our episode sponsor:

1. Check out ⁠⁠⁠⁠⁠⁠⁠⁠Liver Medic ⁠⁠and use code Chloe20 to save 20% on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠"⁠Leaky Gut Repair⁠"⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Brendan's YouTube Channel⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://x.com/livermedic⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Thanks for tuning in!

Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠"

Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Follow Chloe on TikTok @chloe_c_porter

Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!