The Synthesis of Wellness by Chloe Porter

March 08, 2024 106. SS-31 Peptide (Peptides Episode) Deep Dive - How it Works on Mitochondrial Dysfunction, What it Does for Exercise Performance, Current Studies, & More

In this episode, we explore the intricate structure and functions of mitochondria, focusing on the electron transport chain complexes and the generation of reactive oxygen species. We delve into the significance of lipid composition in maintaining mitochondrial integrity, the detrimental effects of ROS-induced lipid peroxidation, and how SS-31 can prevent this damage. Additionally, we discuss the potential therapeutic implications of SS-31 peptide not only on the cellular level in mitigating mitochondrial dysfunction, but also its role in various disease settings and exercise capacity as well.

Topics:

1. Overview of Mitochondrial Structure

- Outer membrane and inner membrane with cristae

- Mitochondrial matrix containing DNA, ribosomes, and enzymes

- Inner membrane with electron transport chain complexes (I to IV) and ATP synthase

2. Functions of Electron Transport Chain Complexes

- Complex I (NADH Dehydrogenase) transferring electrons from NADH to ubiquinone

- Complex II (Succinate Dehydrogenase) transferring electrons from FADH2 to coenzyme Q

- Complex III (Cytochrome bc1 Complex) passing electrons to cytochrome c and pumping protons

- Complex IV (Cytochrome c Oxidase) transferring electrons to oxygen to form water and pumping protons

3. Role of Electron Transfer in ATP Synthesis

- Proton pumping by complexes I, III, and IV creating an electrochemical gradient

- ATP synthase utilizing proton gradient to synthesize ATP from ADP and Pi

4. Generation and Effects of Reactive Oxygen Species (ROS)

- Formation of ROS as byproducts of ATP production

- Types of ROS and their damaging effects on cellular components

5. Causes of ROS Production and Mitochondrial Dysfunction

- Electron leak leading to premature electron reactions with oxygen

- Factors contributing to increased ROS production such as environmental toxins and diet

--- Leela Quantum Tech ---

6. Importance of Lipid Composition in Mitochondrial Membrane

- Phospholipids, particularly cardiolipin, in the inner mitochondrial membrane

- Role of cardiolipin in maintaining membrane integrity and supporting respiration proteins

7. Impact of ROS and Lipid Peroxidation on Mitochondrial Function

- ROS-induced lipid peroxidation affecting cardiolipin composition

- Implications of cardiolipin peroxidation in diseases like metabolic dysfunction and insulin resistance

8. SS-31 Peptide Intro

- Accumulation in the inner mitochondrial membrane

- Dimethyltyrosine residue scavenging oxyradicals and inhibiting lipid peroxidation

9. Mechanisms of Action of SS-31 Peptide

- Stabilization of lipid constructs in the inner mitochondrial membrane

- Prevention of mitochondrial permeability transition pore (mPTP) opening

- Reduction of mitochondrial ROS and prevention of mitochondrial swelling and cell death

10. Applications and Research Areas of SS-31 Peptide

- Studies in neuroinflammation, neurodegeneration, diabetes, age-related diseases, kidney disease, and cardiac function

- Potential as a therapeutic agent for diseases associated with mitochondrial dysfunction

11. Conclusion

- Overview of SS-31 peptide's mechanisms and potential applications

- Reminder to always consult licensed medical professionals.

Thanks for tuning in!

Leela Quantum Tech

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