We are excited to have Dr. Susie Gronski on the podcast today.

Topics:

1. Introduction

- Speaker's journey into specializing in pelvic health for men

- Motivation behind choosing this niche

2. Understanding Pelvic Pain

- Defining pelvic pain

- Common causes of pelvic pain in men

- The mystery surrounding pelvic pain

3. Unique Approach to Treating Pelvic Pain

- Speaker's approach to treatment

- The role of education in the healing process

4. Common Misconceptions and Myths

- Identifying misconceptions about pelvic pain in men

- Impact of misunderstandings on treatment-seeking

5. Lifestyle Factors and Pelvic Pain

- Influence of diet on pelvic health

- The role of exercise in preventing or exacerbating pelvic pain

- Stress and its connection to pelvic issues

6. Preventive Measures and Daily Practices

- Tips for maintaining good pelvic health

- Preventive measures for men to consider

7. Pelvic Floor Exercises and Therapies

- Overview of pelvic floor exercises and therapies

- Importance in managing and preventing pelvic issues

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Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠"

If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening!

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Building upon our previous discussion on optimizing the cortisol awakening response (ep. 89) for more productive mornings, we now shift our focus to the vital role of mitochondria in enhancing our energy and productivity in the new year. We'll explore the intricate structures within mitochondria, the mechanisms leading to dysfunction, and most importantly, uncover effective strategies, including supplements and dietary choices, to optimize mitochondrial function.

Topics:

1. Introduction to Mitochondrial Dysfunction and Energy Production

- Overview of optimizing natural energy levels

- Factors leading to mitochondrial dysfunction and FATIGUE

2. Understanding Mitochondrial Structures

- Outer membrane

- Permeability and function

- Intermembrane space

- Role in proton gradient

- Inner membrane

- Cristae and its significance

- Matrix

- Krebs cycle and NADH generation

- Mitochondrial DNA and ribosomes

3. Mechanisms of Mitochondrial Dysfunction

- Loss of inner mitochondrial membrane potential

- Alterations in the electron transport chain

- Reduced transport of critical metabolites

4. Ways to Improve Mitochondrial Function

- Preface for non-root cause issues

- Factors causing mitochondrial damage

- Example of ROS impact on ATP production

5. Supplements for Enhancing Mitochondrial Function

- Alpha lipoic acid

- Role in increasing glutathione levels

- L-carnitine

- Fatty acid transport and mitochondrial function

- Use in weight loss

- CoQ10

- Involvement in the electron transport chain

- Mitochondrial membrane phospholipids

- Lipid replacement therapy for repairing damage already done

6. Essential Minerals and Micronutrient Blood Panel

- Importance of essential minerals in mitochondrial metabolism

- The need for micronutrient blood panel

7. NAD+ and NADH

- Importance in the electron transport chain

- Precursors like NMN and NR for optimization

8. Other Modalities for Mitochondrial Support

- Mention of red light therapy

- Emphasis on dietary choices and antioxidant intake

- Importance of structural repair with lipid replacement therapy

9. Additional Tools and Research

- Urolithin A for stimulating mitochondrial recycling process

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If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening!

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We are honored to welcome Dr. Jay Goodbinder to the podcast. Dr. Goodbinder is a distinguished graduate who earned valedictorian honors at Cleveland Chiropractic College. With an impressive background in functional medicine, endocrinology, immunology, biochemistry, physiology, and epigenetics, he is an international speaker renowned for his expertise in reversing severe diseases.

Topics:

1. Epigenetics vs. Genetics

- Epigenetics overview

- Introduction to DNA methylation

2. Genetic Predisposition & Chronic Conditions

- Genetic influence on chronic health issues

3. Monitoring Health with Genetic Predisposition

- Importance of tracking biomarkers

- Practical example

4. Nutrition, Genetics, and Epigenetics

- Interplay between nutrition and genetic predisposition

5. Optimizing Wellness with Biohacks

- Peptides, IVs, NAD for wellness & epigenetics

6. Strategies for Enhanced Epigenetics

- Lifestyle changes

- Environmental factors

- Supplements & interventions

Thanks for tuning in!

Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠"

If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening!

Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

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We're honored to welcome Dr. Akil Palanisamy, a Harvard-trained physician and holistic medicine expert, to our podcast. His book, "The Tiger Protocol," blends conventional and holistic medicine, offering a comprehensive approach to treat autoimmune conditions like rheumatoid arthritis, Hashimoto’s, multiple sclerosis, lupus, and more. In this groundbreaking work, Dr. Akil guides you on optimizing your health through proper nutrition, detoxification, infection resolution, microbiome care, and stress management.

Topics:

1. Introduction to Ayurveda for Holistic Health

- Overview of Ayurveda Principles

- 3 Ayurvedic Practices You Can Incorporate into Your Daily Life

2. Understanding the Gut-Brain Connection

- Link Between Leaky Gut and Leaky Brain

- The Connection to Autoimmunity and Inflammatory Responses

3. Exploring the TIGER Protocol

- What Is the TIGER Protocol?

- Key Components and Benefits

4. Addressing Toxins and Infections

- Identifying Different Types of Toxins

- Strategies for Healing from Infections

- Sauna

- Herbs and supplements

5. Customizing the Healing Diet

- Testing? Microbiome, Food Sensitivities, and More

- Tailoring Dietary Approaches for Individual Patients

6. Strategies for Consciously Resting

- Effective Resting Practices for Mental and Physical Well-being

Thanks for tuning in!

Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠"

If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening!

Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

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Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show!

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As we begin a new year, it's crucial to understand how the Cortisol Awakening Response (CAR), which is closely tied to our sleep patterns and overall well-being, can impact our ability to wake up refreshed and ready to tackle the day. We'll explore the intricate biochemical processes that govern the CAR, the factors that can lead to its dysregulation, and practical strategies to reset cortisol's diurnal rhythm for optimal energy and productivity (so you can go above and beyond with your goals in 2024).

Topics:

1. Introduction

- Importance of discussing the cortisol awakening response

- Connection between cortisol awakening response and sleep regulation

- Overview of the cortisol-melatonin diurnal cycle

2. Retinal Ganglion Cells (RGCs) and Light Response

- Role of photoreceptor cells in the retina

- Specialized cells - Retinal Ganglion Cells (RGCs)

- Melanopsin in RGCs and its light sensitivity

- Generation of electrical signals in response to light

- Transmission to the suprachiasmatic nucleus (SCN)

3. Suprachiasmatic Nucleus (SCN) and Light Signals

- Integration of light signals by SCN

- SCN's role in assessing day-night cycle

- Adjustment of the body's internal clock

4. Intracellular Signaling in SCN

- Activation of intracellular signaling pathways

- Role of CREB (transcription factor)

- Transcription and translation of CRH within SCN neurons

- Release of CRH into the bloodstream

5. Adrenocorticotropic Hormone (ACTH) Release

- Travel of CRH to the anterior pituitary gland

- Binding of CRH to corticotroph cells

- Increase in cyclic adenosine monophosphate levels

- Stimulation of ACTH synthesis and release

6. Cortisol Production

- ACTH reaching the adrenal glands

- Stimulation of cortisol production

- Importance of cortisol in the context of discussion

7. Dysregulation of Cortisol Awakening Response

- Factors leading to high or low Cortisol Awakening Response

- Impact on energy levels and waking up

- Focus on the case of chronic fatigue

8. Addressing Dysregulated Cortisol Awakening Response

- Assumption of no underlying root causes

- Strategies for resetting cortisol's diurnal rhythm

- Aligning light exposure with natural environment

- Increasing morning light exposure

- Incorporating physical activity, including high-intensity exercise earlier in the day

- Cold therapy as a stimulatory strategy for the morning

- Avoiding overstimulation at night (caffeine, intense exercise, loud sounds, alcohol, LIGHT)

9. Supporting Melatonin for Cortisol's Diurnal Rhythm

- Importance of melatonin in sleep regulation

- Consuming foods rich in melatonin or precursors

- Exploring endoluten, a pineal peptide bioregulator

Thanks for tuning in!

⁠⁠⁠⁠Book An Intro Coaching Call with Chloe Porter⁠⁠⁠⁠

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If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening!

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We're thrilled to welcome Dr. Petra, a certified naturopathic doctor specializing in functional and Deutenomic medicine. Originally from the Netherlands and now practicing via telemedicine, she graduated from Bastyr University in California in 2016. Dr. Petra's passion lies in in-depth patient research and finding innovative ways to restore health. We're honored to have her on our podcast.

Topics:

1. Understanding Deutenomics and Deuterium

- Explanation of Deutenomics

- Introduction to Deuterium

- Variations in Deuterium Levels in Different Types of Water

2. Deuterium Accumulation and Mitochondrial Dysfunction

- The Link Between Deuterium Accumulation and Mitochondrial Issues

3. Impact of Carbon-Deuterium Bond on Cellular Processes

- Influence of Carbon-Deuterium Bond on Glycolysis

- Effects on the TCA Cycle

- Impact on Oxidative Phosphorylation

4. Consequences of Deuterium Accumulation

- Discussing Potential Downstream Effects

5. Factors Leading to Deuterium Accumulation and Reduction Strategies

- Causes of Deuterium Accumulation in the Body

- Strategies for Decreasing Deuterium Accumulation

6. Hydration Strategies for Deuterium-Depleted Water

- Approaches to Support the Creation of Deuterium-Depleted Water in Mitochondria

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If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening!

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I absolutely loved this conversation, and I resonate greatly with her thought process! Carrie has multiple degrees in biology, nutrition, and bodywork, and her relentless enthusiasm to learn has made her one of the leading educators in the emerging field of quantum biology. She combines deep research and clear explanations of the complex quantum mechanisms at play in the human body to teach people how to use light, water, and nature to thrive. Carrie is a sought-after speaker and guest lecturer. She currently sees clients in her online practice. She is also the lead faculty member and on the Board of Advisors for the Quantum Biology Collective, the world’s premier certification for Applied Quantum Biology in clinical practice.

Topics:

1. Quantum Biology and Cellular Function

- Explanation of Quantum Biology

- Role of Quantum Biology in Understanding Cellular Function

2. Light's Influence on the Body

- Connection between Quantum Biology and Light

- Impact of Light on Circadian Rhythms

- Influence of Light on Mitochondrial Function

3. Optimal Light Exposure for Cellular Health

- Specific Types of Light to Consider

- Optimal Times for Light Exposure

4. Cellular Hydration and Its Factors

- How Cells Become Hydrated

- Deuterium and Its Impact on Hydration

- Exclusion Zone Water and Effective Hydration

5. The Impact of Proper Hydration

- Relationship between Hydration and Detoxification

- Hydration's Role in Managing Edema

- Hydration and Its Effect on Lymphatic Flow

6. Electromagnetic Fields (EMFs) and Cellular Health

- How EMFs Affect Cells

- EMFs' Influence on Mitochondria

- The Modern Environment and Increasing EMF Exposure

Thanks for tuning in!

Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠"

If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening!

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Or visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠linktr.ee/synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show!

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Building upon our previous discussion on growth factors like EGF and FGF (featured in episode 84: part 1), we'll explore a range of intriguing peptides that have gained popularity for their skin-enhancing properties. From stimulating collagen production to calming irritated skin and even targeting dynamic wrinkles (acting like "botox in a bottle"), we'll cover a variety of topical peptides that are revolutionizing skincare. Stay tuned for this topical cosmetic peptide guide!

Topics:

1. Introduction

- Recap of last week's episode on growth factors (EGF and FGF)

- Shift in focus to topical peptides

- Skin anatomy for context

2. Skin Anatomy Overview

- Epidermis

- Layers and sublayers

- Cornification process

- Function of each sublayer

- Dermis

- Papillary and reticular dermis

- Role of fibroblasts

- Components and functions of the dermis

3. Topical Peptides

- Palmitoyl Tripeptide-1

- Mimicking collagen

- Stimulating collagen production

- Benefits for skin structure and sagging prevention

- Palmitoyl Tetrapeptide-7

- Relation to IgG protein

- Reduction of IL-6 secretion and inflammation

- Use in calming irritated skin

- Palmitoyl Tripeptide-8

- Soothing irritated skin or for sensitive skin

- Reduction of inflammatory cytokines like IL-8, edema, and capillaries

- Palmitoyl Tetrapeptide-38 (Matrixyl 6000)

- Comprehensive stimulation of skin matrix components

- Greater collagen production and epidermal support

- Benefits for skin structure, firmness

- Neurotransmitter-Inhibiting Topical Peptides

- Targeting dynamic wrinkles caused by muscle contraction

- Reduction of muscle contractions and expression lines

- Introduction of Acetyl Hexapeptide-8 and Acetyl Octapeptide-3

4. Other Topical Peptides (Future Episode & Featured on My Instagram)

- Eyelash growth and nail growth peptides

- Solutions for under-eye bags and dark circles

Thanks for tuning in!

⁠⁠⁠Book An Intro Coaching Call with Chloe Porter⁠⁠⁠

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If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening!

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We're honored to have Dr. Daved Rosensweet on the podcast. With a medical degree from the University of Michigan in 1968, he's been in private practice since 1971, spanning multiple states. Dr. Rosensweet notably led the first Nurse Practitioner training program in the U.S. and played a key role in health promotion for New Mexico. He also educates health professionals on bio-identical hormone treatments for menopausal women.

Topics:

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Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠"

If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening!

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Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

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In this episode, we are getting into all things cosmetic peptides and growth factors (and their impact on skin). We will also quickly review the essential structure of our skin, from the surface epidermis to the underlying dermis and sublayers/cellular components of each. This knowledge will set the stage for our discussion on the pivotal roles of EGF and FGF in anti-aging. Also, stay tuned for Part 2, where we'll delve deeper into these topics.

Topics:

1. Introduction

- Brief review of the anatomy of the skin

- Overview of the topics to be discussed (cosmetic peptides and growth factors)

2. Epidermis

- Overview of the epidermis

- Sublayers of the epidermis

- Stratum Corneum

- Stratum Lucidum

- Stratum Granulosum

- Stratum Spinosum

- Stratum Basale

- Functions and characteristics of each sublayer

- Keratinocyte differentiation and lipids production

- Role of melanocytes and Merkel cells

3. Dermis

- Overview of the dermis

- Sublayers of the dermis

- Papillary Dermis

- Reticular Dermis

- Composition and functions of each sublayer

- Role of collagen, elastin, fibroblasts, sebaceous glands, sweat glands, hair follicles, and mast cells

4. Cosmetic Peptides and Growth Factors

- Introduction to EGF (Epidermal Growth Factor)

- Mechanism of action

- Effects on keratinocytes and epidermis

- Indirect effects on collagen and elastin production

- Application in skincare

- Introduction to FGF (Fibroblast Growth Factor)

- Mechanism of action

- Effects on fibroblasts and dermis

- Enhancement of skin firmness and elasticity

- Upcoming topics in Part 2

- Other growth factors

- Additional cosmetic topical peptides

- Tips and tricks for skincare formulations

Thanks for tuning in!

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