I have used the terms over methylator and undermethylation in the past to help categorize people to streamline their supplement start with MTHFR or other methylation imbalance, but the terms themselves can be confusing and misleading because they imply a biochemical state that isn't actually there.

She breaks down the considerations for symptom management and potential risks, particularly regarding tumors and blood labs. In this episode of 'To Health With That,' naturopathic doctor Amy Neuzil discusses the complexities surrounding methylfolate dosing for individuals with MTHFR. High doses of methylfolate could come with some of the same risks as high-dose folic acid, so it's essential to find the right dose for you without overdoing it. The three factors to consider are symptom management, potential risks, and serum folate levels. She breaks down the considerations for symptom management, potential risks, particularly regarding tumors, and blood labs. Amy also shares her own methylfolate regime and emphasizes the importance of personalized care and listening to one’s body.

Folate is a great thing - it's vitamin B9 and your body needs it to make new cells, replicate DNA, and so much more. But there are risks of too much folate, so how much folic acid is too much? And how dangerous is it to take high dose folic acid over time? The research exists for high dose folic acid, but what about L-5MTHF, or methyl folate? Does high dose methyl folate have the same risks as high dose folic acid?

We have so many questions, and very few definitive answers, but there is lots of information that we do have.

Thanks for watching! Here are some other links that you might like.

Genetic Rockstars - a community for people making the most of their favorite genes and getting better together (first month free for YouTubers!): https://community.tohealthwiththat.com/plans/204575?bundle_token=4da8ed9c5f00a92363bcd15ad2ac26dd&utm_source=manual

FREE MTHFR Basics course: https://courses.tohealthwiththat.com/p/mthfr-basics

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That's right - season 4 of the To Health With That podcast is finished, so let's talk about what you should be doing this summer (having fun), what I should be doing in the fall (writing), and what kind of episodes you can expect.

Gentle MTHFR Detox Protocol

In Season 4, Episode 21 of the To Health With That podcast, naturopathic doctor Amy Neuzil discusses strategies to combat fatigue by focusing on adrenal health.

In season four of the 'To Health With That' podcast, hosted by naturopathic doctor Amy Noozle, the focus shifts to understanding and combating fatigue, with a specific emphasis on adrenal fatigue.

In this episode of the 'To Health With That' podcast, host Amy Neuzil, a naturopathic doctor, explores adrenal fatigue, a widespread issue attributed to the constant stress of modern life. The episode delves into the four stages of adrenal fatigue: 'Crushing it,' where individuals feel highly productive and energized due to high cortisol levels; 'Tired but wired,' marked by emerging fatigue and anxiety; 'Burning down,' where symptoms worsen, including greater fatigue and sleep issues; and 'Burned out,' a phase of significant functional impairment. Neuzil emphasizes the importance of early detection and intervention to prevent reaching the burnout stage. The episode aims to educate listeners on recognizing the signs of adrenal fatigue and offers a lead into the next episode, which will focus on non-hormonal strategies for nourishing and healing the adrenals.

Understanding and Addressing Adrenal Fatigue

Doing a good detox protocol takes some preparation and some of the best preparation you can do is finding out if your genes are making detoxification harder for you somewhere. Some gene SNPs have the potential to make detox harder by interfering with phase two conjugation reactions. These include MTHFR, MTR, MTRR, GST, GPX, COMT, HNMT, UGT1A1, SULT genes, NAT1, and NAT2.