100 Not Out

Today on 100 Not Out we have the privilege of speaking to someone who is 100 Not Out on the day of recording (August 11)! Clary Hanna van Noppen has lived a life full of resilience, humour, and love. Born in Holland, she survived the hardships of World War II, raised six children, and built a family that remains close-knit to this day — with all six siblings, now aged between 60 and 77, coming together to celebrate her centenary.

For more on Damo go to www.damiankristof.com

Today we dive into the “wonder drug” Ozempic and its prominence in the conversation around weight loss, longevity, and biohacking. With Ozempic making headlines as a modern-day solution for weight management, we discuss what it is, how it works, its risks and side effects, and where it fits into the wider discussion of sustainable health and lifestyle change.

**Key Topics:**

– **How Ozempic Works:**  

  Damo explains Ozempic’s primary functions:

– **Philosophy & Practicality of Pharmaceutical Interventions:**  

  The conversation addresses when pharmaceutical options become appropriate, such as when lifestyle modifications haven’t worked or when someone is in an urgent health situation.

– **Biohacking & Longevity Claims:**  

  – We look at recent claims about Ozempic’s potential to “reverse biological aging by 3.1 years,” discussing scientific skepticism and comparisons to drugs like Metformin and therapies like stem cells.

  – We discuss our concerns over the methodology and implications of “biological age” metrics.

– **Risks & Side Effects:**  

  Common and serious side effects mentioned:

  – Nausea, vomiting, constipation, abdominal pain

  – Appetite suppression due to delayed gastric emptying

  – Gallbladder problems, fatigue, muscle loss, potential thyroid tumors  

  *Muscle loss is highlighted as the most significant concern for healthy aging.*

– **Lifestyle Change vs. Medical Intervention:**  

  Damo discusses the “second-last resort” of real, sustained lifestyle and dietary change before resorting to pharmaceutical interventions. The reality, challenges, and sustainability of lifestyle changes are explored.

**Memorable Quotes:**

– “Ideally, people would make a decision about their health and wellbeing long before pharmaceutical intervention is required.” – Dr. Damian Kristof

– “It’s taking all the fun out of this thing called food.” – Marcus Pearce

For more on Damo go to www.damiankristof.com

For more on Marcus go to www.marcuspearce.com.au

For more on 100 Not Out go to www.100notout.com

Damo went to Europe recently and didn’t like what he saw in the photos upon his return.

Body image – and beyond that inner health – has as much to do with our own behaviours and beliefs as it does what we eat and how we move.

Damo has decided to crank up his movement practices in all of cardio, strength and flexibility – and we discuss the why, how, what and when in this honest and open conversation around body image and using disappointment as a fuel.

For more on Damo go to www.damiankristof.com

For more on Marcus go to www.marcuspearce.com.au

For more on 100 Not Out go to www.100notout.com

Our favourite vegan author has passed away. John Robbins, a trailblazer in the health field and author of many books including Healthy at 100, passed away recently following complications from Post Polio Syndrome. He was 77. 

It’s perhaps possible that 100 Not Out would not exist without John Robbins. We share why on this episode. 

John Robbins was one of the few nutrition authorities who could broaden the conversation around food beyond calories and macronutrients. He was very clear on the value of movement, social, purpose, family, wealth and all areas of life. 

A beautiful tribute video to John Robbins can be found here. 

For more on Damo go to www.damiankristof.com

For more on Marcus go to www.marcuspearce.com.au

For more on 100 Not Out go to www.100notout.com

Damo has recently been to Europe on a holiday and caught up with his son Jackson.

This births a conversation the importance of actively creating, chasing and aspiring for magic moments and memory-making experiences in life.

We’ve said it many times before that people with a compelling future for their life live longer than those who don’t.

In the modern world, so many of us have family and loved ones who live far away. One of the most special things we can do is to see them in person. Not only is it an incredibly oxytocin boost (the hormone of love), it creates an enthusiasm in our days, weeks and months, knowing that magic moments are on the high horizon.

At the same time, magic moments can occur every day in simple forms like sunshine and fresh air. We’re not saying you need to go overseas in order to experience them! What we are saying is that the creation of memory making experiences is an essential part to a great life.

For more on Damo go to www.damiankristof.com

For more on Marcus go to www.marcuspearce.com.au

For more on 100 Not Out go to www.100notout.com

Today we dive into the hot topic of vitamin B6 toxicity. Fun fact: most B vitamins, including B6, are produced in the gut by our own bacteria! Today we debunk myths about B6, discussing how supplementation should always complement a healthy diet—not replace it. Key lesson: mega-dosing on isolated B vitamins can be risky, especially when they’re found in everything from protein shakes to multivitamins. Always check your supplement labels, consider your total nutrient load, and consult a knowledgeable health practitioner before adding new supplements to your routine!

For more on Damo go to www.damiankristof.com

For more on Marcus go to www.marcuspearce.com.au

For more on 100 Not Out go to www.100notout.com

Today we dive into the tricky world of timing, decision-making, and the classic excuses that hold us back—like “I’m too busy” or “It’s just not the right time.” Through insightful stories and a few memorable parables, we challenge listeners to stop waiting for the perfect moment to invest in health and wellbeing. Whether it’s starting new habits, focusing on longevity, or kicking excuses to the curb, we discuss practical strategies that go beyond the “right time” - because waiting can come at a cost. Tune in for a motivating conversation on mastering the art of aging well!

For more on Damo go to www.damiankristof.com

For more on Marcus go to www.marcuspearce.com.au

For more on 100 Not Out go to www.100notout.com

Marcus has been having a similar breakfast and lunch and wonders if his microbiome diversity is taking a hit as a result. 

Damo has all the answers to the big questions on microbiome diversity - how it happens, how to improve it, and why it’s not as easy as we hope. 

The boys reference Dr Ivo Pirisi - their host on their Sardinian Longevity Experiences - and his challenge of consuming 75 different foods in a week. It’s not as simple as it sounds. And all listeners are invited to give it a crack!

For more on Damo go to www.damiankristof.com

For more on Marcus go to www.marcuspearce.com.au

Photo by Jacopo Maiarelli on Unsplash

Biological age testing is all the rage at the moment. Recent media coverage raises some good points about the ease of confusion, in spite of and perhaps because of the influx of information that we are constantly bombarded with. 

Damo has a long history in biological age testing and as a result can give some important context to what was measured 30 years ago compared to what is measured today - and how it’s done. 

Given that results can vary by up to 9 years (according to the latest research), more caution than ever is required when having testing done - and knowing what’s being tested, and how vital it is or isn’t to your health and longevity - is more important than ever before. 

Enjoy the episode!

For more on Damo go to www.damiankristof.com

A regular listener of the podcast (shout out to Ryan) has sent us through an email about friendships – and what do when you’re the one doing all the organising and keeping the group together.

It’s a position many people find themselves in. If you’re the connector of your group, you’d be forgiven for having moments of “stuff it, I’m doing this anymore” when it feels like people take your role for granted.

With social being such an important part of longevity, we discuss Ryan’s challenge and all the spin-offs that occur from the modern-day social conundrum.

Photo by Priscilla Du Preez 🇨🇦 on Unsplash