This episode is brought to you by Troscriptions.

Tired, drained, and ready for a change? You are not alone. In fact, 94% of Americans experience some degree of mitochondrial dysfunction that is possibly leading to unwanted symptoms such as brain fog, fatigue, weight gain, and even poor mental health. In this episode with Dr. Scott Sherr, MD you will learn how modern life has made us evolutionarily unfit for our environment, and why living in constant fight-or-flight mode leads to what he calls "the sympathetic spiral of doom." Together, we explore early warning signs of cellular decline, the link between mood and mitochondria, and practical strategies for restoring balance — from better sleep and parasympathetic recovery to optimizing nutrition and lab testing. This episode is a masterclass in understanding your body's energy systems and how to reclaim your vitality at the cellular level.

Follow Scott @drscottsherr

Follow Chase @chase_chewning

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00:01 What Is Mitochondrial Dysfunction? — 94% of U.S. adults struggle with energy and detoxification.

01:28 Meet Dr. Scott Sherr — His background in internal medicine and health optimization.

04:00 The Science of ATP — How your body creates 150 pounds of energy every day — and the hidden cost.

06:58 What's Breaking Our Mitochondria — Sugar, medications, toxins, and chronic stress.

09:28 Why We're Not Built for Modern Life — Evolutionary mismatch and constant overstimulation.

12:52 Energy Production vs. Detoxification — The "plumbing" analogy that explains cellular backup.

15:48 Early Warning Signs — Fatigue, mood swings, slow recovery, and why energy equals emotion.

20:59 You Can Feel Fine and Still Be Unhealthy — Why "not sick" doesn't mean "optimized."

24:53 Optimizing Cellular Health — Nutrient testing, heavy metals, inflammation, and resilience between ages 21–30.

27:54 The #1 Mitochondrial Killer: Stress — Why sympathetic overdrive is the hidden threat to energy.

30:41 The Sympathetic Spiral of Doom — How stress hormones shut down energy production.

35:59 Breaking the Spiral — Awareness, HRV, recovery, and restoring nervous system balance.

41:46 The Role of Safety and GABA — How feeling unsafe keeps you stuck in fight-or-flight.

46:49 Biohacks That Actually Work — GABA, sauna, sleep, and Dr. Sherr's nightly recovery ritual.

49:31 Modeling Health for the Next Generation — Mindfulness, meditation, and leading by example.

53:15 Ever Forward — Energy as currency and the art of being both present and progressing.

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Episode resources:

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